We have read with interest the manuscript entitled “Clinical performance of drug-eluting stents with biodegradable polymeric coating: a meta-analysis and systematic review” by Ahmed et al1, recently published in “EuroIntervention”. Unfortunately, from our point of view, their meta-analysis presents several important methodological drawbacks.
First of all, Ahmed et al included in their meta-analysis the COSTAR II trial2; this study was set up to test a novel stent designed specifically for drug delivery via individual wells filled with a drug and an absorbable polymer in a structure of cobalt-chromium alloy. This structure is profoundly different…