Randomised Trials in PCI for STEMI

Randomised Trials in PCI for STEMI

On this page you will find a list of randomised trials in PCI for STEMI published in some of the world's top cardiology and interventional cardiology journals.

2.1 - FIBRINOLYSIS VS PCI

  • Fibrinolysis or primary PCI for STEMI: STREAM
  • Reperfusion STEMI: PPCI vs pharmaco-invasive: STREAM 1-year

2.2 - DES VS BMS

  • DES vs BMS for STEMI – 5-year outcome: DEDICATION
  • Everolimus-eluting vs BMS: EXAMINATION
  • EES vs BMS for STEMI: EXAMINATION 2 years
  • Everolimus eluting stents vs BMS for STEMI: Examination 5 years
  • SES vs BMS for STEMI: MISSION! 5 years
  • COMFORTABLE AMI trial
  • Biolimus-eluting stents vs BMS for STEMI: COMFORTABLE 2 years

2.3 - DES VS DES

  • Everolimus vs paclitaxel stents for MI: COMPARE
  • Bio-active stent versus EES in ACS: BASE-ACS trial
  • XAMI trial: DES for primary PCI

2.4 - EES VS SES

  • EES vs SES for primary PCI of acute MI: XAMI trial - 3 years
  • SES vs EES for primary PCI STEMI: RACES-MI trial
  • Durable vs biodegradable polymer-DES for STEMI: pooled analysis

2.5 - GP IIB/IIIA

  • IC vs IV abciximab primary PCI: AIDA-STEMI trial
  • DES or BMS with or without abciximab in PPCI: DEBATER
  • INFUSE-AMI trial: 1-year outcome

2.6 - DIRECT THROMBIN INHIBITORS

  • Bivalirudin before emergency transport for primary PCI: EUROMAX
  • STEMI transport under bivalirudin vs heparins with optional GPI: EUROMAX
  • Prasugrel+bivalirudin vs clopidogrel+heparin for primary PCI: BRAVE 4
  • Heparin vs bivalirudin in primary PCI: HEAT-PPCI

2.7 - CULPRIT VS TOTAL REVASCULARISATION

  • Pre-hospital ticagrelor in STEMI: ATLANTIC
  • Preventive PCI non-culprit lesion in STEMI: PRAMI
  • Complete vs culprit-only revascularisation for PCI STEMI: CvLPRIT Trial
  • STEMI: complete revascularisation vs culprit lesion only: DANAMI-3 – PRIMULTI
  • Deferred vs. Conventional stent implantation in STEMI patients: DANAMI 3 – DEFER
  • PCI Strategies in patients with acute myocardial infarction and cardiogenic shock: CULPRIT SHOCK (Added in December 2017)

2.8 - THROMBECTOMY ASPIRATION

  • Thrombectomy for STEMI: MUSTELA
  • Aspiration thrombectomy effect on microvascular obstruction: TATORT-NSTEMI trial
  • Thrombus aspiration before P-PCI for STEMI: TASTE
  • Thrombus aspiration for myocardial infarction: TASTE – 1 year
  • Thrombectomy prior to primary PCI for STEMI: TOTAL study
  • Thrombus aspiration for PCI-STEMI-TOTAL trial 1 year
  • MGuard implantation for STEMI: MASTER 1 year

2.9 - PRE-CONDITIONING

  • Remote ischemic conditioning in addition to PCI for STEMI: CONDI
  • Remote ischaemic conditioning in primary PCI: CONDI
  • Ischemic post-conditioning during primary PCI: POST trial

2.10 - CELL THERAPY

  • Stem cell therapy: CADUCEUS
  • Intracoronary infusion of peripheral blood stem cell therapy in AMI: MAGIC-CELL-3-DES
  • Timing of bone marrow mononuclear cell delivery on LV function: TIME
  • Intracoronary bone marrow-derived mononuclear cells injection on post-MI LV-function
  • Intracoronary bone marrow therapy: REPAIR-AMI

2.11 - HYPOTHERMIA

  • Hypothermia as adjunct to primary PCI: CHILL-MI

2.12 - PRETREATMENT PPCI

  • Cyclosporine before PCI in patients with STEMI: CIRCUS trial
  • Early iv beta-blockers in STEMI before PPCI: EARLY BAMI study

Access these randomised trials here

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