Von Willebrand Factor Multimers during Transcatheter Aortic-Valve Replacement

Selected in The New England Journal of Medicine by R. Dworakowski

References

Authors

E Van Belle, A Rauch, F Vincent, E Robin, M Kibler, J Labreuche, E Jeanpierre, M Levade, C Hurt, N Rousse, JB Dally, N Debry, J Dallongeville, A Vincentelli, C Delhaye, JL Auffray, F Juthier, G Schurtz, G Lemesle, T Caspar, O Morel, N Dumonteil, A Duhamel, C Paris, A Dupont-Prado, P Legendre, F Mouquet, B Marchant, S Hermoire, D Corseaux, K Moussa, A Manchuelle, JJ Bauchart, V Loobuyck, C Caron, C Zawadzki, F Leroy, JC Bodart, B Staels, J Goudemand, P J. Lenting, and S Susen

Reference

N Engl J Med 2016; 375:335-344

Published

July 2016

Link

Read the abstract

My Comment

What is known

Paravalvular aortic regurgitation (PVR) is a common complication of TAVI and patient outcomes are adversely affected by the degree of PVR that occurs. Usually a degree of PVR is assessed immediately after valve deployment either by echocardiography or using haemodynamic evaluation. None of these techniques are ideal, and all have their limitations. The idea of having a point-of-care additional screening method is thus of great interest. The von Willebrand factor could be used as an endogenous sensor of haemodynamic forces and shear stress as, for instance, in those conditions associated with supra-physiologic shear stress where von Willebrand factor mulitimers undergo rapid degradation, but their distribution normalises very quickly after restoration of normal flow. 

Major findings 

In this study published in NEJM, Van Belle et al present the use of a point-of-care haemostatic test. As a method for predicting aortic regurgitation (AR) after TAVI; the authors look at closure time with adenosine diphosphate (CT-ADP) as assessed with the use of a Platelet Function Analyzer 100 along with the presence of defects in high-molecular-weight (HMW) multimers of the von Willebrand factor (vWF). One hundred and eighty-three (183) patients undergoing TAVI were enrolled in this single-centre study. Three qualitative measures of vWF function (including the HMW-multimer ratio) were assessed and a CT-ADP assay was performed at baseline: five and 15 minutes after TAVI implantation; five minutes after additional balloon dilation – and at the end of the procedure – five minutes after removal of the delivery sheath. Forty-six (46) patients were identified as having PVR after TAVI implantation by transoesophageal echocardiography (25%). PVR improved after post-dilatation in 20 patients. A CT-ADP value of less than 180 seconds was both a very sensitive (92.3%), and specific (92.4%), marker of residual PVR. Similarly, the HMW-multimer ratio remained low in cases of persistent AR. The negative predictive value was 98.6%. Even more importantly, these results correlated with one-year mortality.

Based on this, the authors concluded that a CT-ADP test could be a very useful point-of-care test.

My comment

Van Belle et al presented a very interesting concept and provided evidence to the effect that a change in the von Willebrand factor and platelet function can be monitored during TAVI, and that there is a correlation with PVR. TOE remains the gold standard in detecting and assessing aortic regurgitation after TAVI. However, increasing numbers of TAVI procedures are performed under conscious sedation without the routine use of TOE. Assessment of AR with TTE might be challenging and difficult. In contrast to echocardiography (TOE/TTE), the CT-ADP test focuses on platelet function status in relation to increased shear stress.

While these results are very promising as well as interesting, they have to be taken with caution before applying routinely in clinical practice. The study was performed on a relatively small group of patients and no correlation has been shown between the degree of PVR and the level of platelet dysfunction. HMW defects are observed in any situation of increased shear stress. Apart from PVR, there are potentially other complications of the TAVI procedure that might result in high-velocity blood flow (for instance: VSD, transvalvular AR, etc.). Paradoxically, severe AR might cause less shear stress than high-velocity mild/moderate AR. Other comorbidities need to be taken into consideration, such as coexisting tricuspid or mitral regurgitation.

Despite these limitations, Van Belle et al have presented a very interesting concept showing that the use of CT-ADP test, in conjunction with imaging, can be a useful, additional tool for PVR assessment.

See the Hot line session on the same topic, presented by E. Van Belle at EuroPCR 2015: Von Willebrand factor, as a highly sensitive sensor of flow and bedside test to detect and monitor aortic regurgitation during TAVI procedure: results from the WiTAVI study

No comments yet!

array(2) {
  [153814]=>
  object(eZ\Publish\Core\Repository\Values\Content\Content)#4890 (3) {
    ["fields":protected]=>
    array(42) {
      ["title"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4887 (1) {
          ["text"]=>
          string(90) "ACURATE neo™ Aortic Valve System  shows safety & efficacy results comparable to SAPIEN 3"
        }
      }
      ["url_title"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#5026 (1) {
          ["text"]=>
          string(0) ""
        }
      }
      ["visibility_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#5027 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["meta_title"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4881 (1) {
          ["text"]=>
          string(90) "ACURATE neo™ Aortic Valve System  shows safety & efficacy results comparable to SAPIEN 3"
        }
      }
      ["meta_description"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4879 (1) {
          ["text"]=>
          string(188) "Comparable performance for ACURATE neo and SAPIEN 3 with no significant differences at 30 days in safety outcomes, including the VARC-2 early safety and device failure composite endpoints."
        }
      }
      ["classification"]=>
      array(1) {
        ["eng-GB"]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4873 (1) {
          ["tags"]=>
          array(2) {
            [0]=>
            object(Netgen\TagsBundle\API\Repository\Values\Tags\Tag)#4874 (8) {
              ["id":protected]=>
              string(3) "827"
              ["parentTagId":protected]=>
              string(3) "865"
              ["mainTagId":protected]=>
              string(1) "0"
              ["keyword":protected]=>
              string(4) "TAVI"
              ["depth":protected]=>
              string(1) "3"
              ["pathString":protected]=>
              string(13) "/861/865/827/"
              ["modificationDate":protected]=>
              object(DateTime)#4877 (3) {
                ["date"]=>
                string(26) "2016-10-27 16:43:43.000000"
                ["timezone_type"]=>
                int(3)
                ["timezone"]=>
                string(12) "Europe/Paris"
              }
              ["remoteId":protected]=>
              string(32) "615bb11c7415503edb26cddd0dd14a51"
            }
            [1]=>
            object(Netgen\TagsBundle\API\Repository\Values\Tags\Tag)#4872 (8) {
              ["id":protected]=>
              string(3) "865"
              ["parentTagId":protected]=>
              string(3) "861"
              ["mainTagId":protected]=>
              string(1) "0"
              ["keyword":protected]=>
              string(34) "Interventions for Valvular Disease"
              ["depth":protected]=>
              string(1) "2"
              ["pathString":protected]=>
              string(9) "/861/865/"
              ["modificationDate":protected]=>
              object(DateTime)#4875 (3) {
                ["date"]=>
                string(26) "2016-10-27 16:43:43.000000"
                ["timezone_type"]=>
                int(3)
                ["timezone"]=>
                string(12) "Europe/Paris"
              }
              ["remoteId":protected]=>
              string(32) "3aa2059f04b260b8b6f5f6b45a612d37"
            }
          }
        }
      }
      ["focus_on"]=>
      array(1) {
        ["eng-GB"]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4871 (1) {
          ["tags"]=>
          array(0) {
          }
        }
      }
      ["free_tags"]=>
      array(1) {
        ["eng-GB"]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4869 (1) {
          ["tags"]=>
          array(0) {
          }
        }
      }
      ["date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4867 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["subtitle"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4865 (1) {
          ["text"]=>
          string(30) "Sponsored by Boston Scientific"
        }
      }
      ["image"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Image\Value)#4863 (9) {
          ["id"]=>
          NULL
          ["alternativeText"]=>
          NULL
          ["fileName"]=>
          NULL
          ["fileSize"]=>
          NULL
          ["uri"]=>
          NULL
          ["imageId"]=>
          NULL
          ["inputUri"]=>
          NULL
          ["width"]=>
          NULL
          ["height"]=>
          NULL
        }
      }
      ["top_text"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4861 (1) {
          ["xml"]=>
          object(DOMDocument)#4885 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(968) "Multi-centre propensity-matched comparison study1 between ACURATE neo Aortic Valve System and Edwards SAPIEN 3 Transcatheter Heart Valve, published in October’s edition of the Journal of the American College of Cardiology (JACC) shows comparable procedural outcomes:Observational, propensity-matched multicenter comparison of ACURATE neo and SAPIEN 3 from 3 high volume centers in Germany (DHZ Munich, UK Regensburg, Kerckhoff Klinikum Bad Nauheim)1,121 consecutive patients between Jan. 2014 and Jan. 2016 with symptomatic, severe stenosis of the native aortic valve treated with transfemoral TAVI using ACURATE neo (n = 311) or SAPIEN 3 (n = 810)To increase statistical power, a 1-to-2 nearest neighbor matching was used to identify 2 control cases treated with SAPIEN 3 (n = 622) for each case treated with ACURATE neo (n = 311)Endpoints: device failure and early safety composite endpoint at 30 days according to VARC-2 criteriaView full JACC publication "
          }
        }
      }
      ["main_text"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4859 (1) {
          ["xml"]=>
          object(DOMDocument)#4883 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(852) "Key facts highlighted in the study:Comparable performance for ACURATE neo and SAPIEN 3 with no significant differences at 30 days in safety outcomes, including the VARC-2 early safety and device failure composite endpoints.*Download publication summary © Europa Group – Original recording at PCR London Valves 2017References* Comparable VARC-2 device failure composite endpoint with ACURATE neo versus SAPIEN 3 (10.9% vs. 9.6%, p=n.s.) and early safety composite endpoint (15.8% vs. 15.6%, p=n.s.).** According to VARC-2, elevated gradients >20 mmHg are defined as mild stenosis, are assessed as Device Failure and may indicate prosthetic valve dysfunction.Husser O, et al. Multicenter comparison of novel self-expanding versus balloon-expandable transcatheter heart valves. JACC Cardiovasc Interv. 2017 Oct 23;10(20):2078-2087.SH-512201-AA NOV2017"
          }
        }
      }
      ["sponsor_disclaimer"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4857 (1) {
          ["text"]=>
          string(61) "With an unrestricted educational grant from Boston Scientific"
        }
      }
      ["partners"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\RelationList\Value)#4855 (1) {
          ["destinationContentIds"]=>
          array(1) {
            [0]=>
            int(246832)
          }
        }
      }
      ["contributors"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\RelationList\Value)#4853 (1) {
          ["destinationContentIds"]=>
          array(0) {
          }
        }
      }
      ["alt_contributors"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4851 (1) {
          ["xml"]=>
          object(DOMDocument)#4882 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(0) ""
          }
        }
      }
      ["enable_comments"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4849 (1) {
          ["bool"]=>
          bool(false)
        }
      }
      ["show_disclaimer"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4847 (1) {
          ["bool"]=>
          bool(true)
        }
      }
      ["redirect_to_url"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Url\Value)#4845 (2) {
          ["link"]=>
          NULL
          ["text"]=>
          NULL
        }
      }
      ["redirect_to_object"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Relation\Value)#4843 (1) {
          ["destinationContentId"]=>
          NULL
        }
      }
      ["hide_related_content_block"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4841 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(2)
          }
        }
      }
      ["hide_promoted_content_block"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4839 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(2)
          }
        }
      }
      ["hide_recommended_content_block"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4837 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(2)
          }
        }
      }
      ["is_news"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4835 (1) {
          ["bool"]=>
          bool(false)
        }
      }
      ["is_news_start_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4831 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["is_news_expiration_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4827 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["allowed_in_home"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4829 (1) {
          ["bool"]=>
          bool(false)
        }
      }
      ["allowed_in_home_start_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4821 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["allowed_in_home_expiration_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4825 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["is_recommended"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4823 (1) {
          ["bool"]=>
          bool(false)
        }
      }
      ["is_recommended_start_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4815 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["is_recommended_expiration_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4819 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["is_promoted"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4817 (1) {
          ["bool"]=>
          bool(true)
        }
      }
      ["is_promoted_start_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4814 (2) {
          ["date"]=>
          object(DateTime)#4811 (3) {
            ["date"]=>
            string(26) "2018-01-11 00:00:00.000000"
            ["timezone_type"]=>
            int(3)
            ["timezone"]=>
            string(12) "Europe/Paris"
          }
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["is_promoted_expiration_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4809 (2) {
          ["date"]=>
          object(DateTime)#4810 (3) {
            ["date"]=>
            string(26) "2018-12-31 00:00:00.000000"
            ["timezone_type"]=>
            int(3)
            ["timezone"]=>
            string(12) "Europe/Paris"
          }
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["show_promoted_label"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4807 (1) {
          ["bool"]=>
          bool(true)
        }
      }
      ["do_not_index"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4805 (1) {
          ["bool"]=>
          bool(false)
        }
      }
      ["teaser_image"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Image\Value)#4803 (9) {
          ["id"]=>
          string(276) "pcronline/cases-resources-images/industry-partner-perspectives/promoted-content/2017/acurate-neo-aortic-valve-system-shows-safety-efficacy-results-comparable-to-sapien-3/5048829-29-eng-GB/ACURATE-neo-Aortic-Valve-System-shows-safety-efficacy-results-comparable-to-SAPIEN-3.jpg"
          ["alternativeText"]=>
          string(90) "ACURATE neo™ Aortic Valve System  shows safety & efficacy results comparable to SAPIEN 3"
          ["fileName"]=>
          string(88) "ACURATE-neo-Aortic-Valve-System-shows-safety-efficacy-results-comparable-to-SAPIEN-3.jpg"
          ["fileSize"]=>
          int(25246)
          ["uri"]=>
          string(303) "/var/pcrov3/storage/images/pcronline/cases-resources-images/industry-partner-perspectives/promoted-content/2017/acurate-neo-aortic-valve-system-shows-safety-efficacy-results-comparable-to-sapien-3/5048829-29-eng-GB/ACURATE-neo-Aortic-Valve-System-shows-safety-efficacy-results-comparable-to-SAPIEN-3.jpg"
          ["imageId"]=>
          string(14) "242519-5048829"
          ["inputUri"]=>
          NULL
          ["width"]=>
          string(3) "448"
          ["height"]=>
          string(3) "220"
        }
      }
      ["teaser_title"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4898 (1) {
          ["text"]=>
          string(91) "ACURATE neo™ Aortic Valve System shows safety & efficacy results comparable to SAPIEN 3¹"
        }
      }
      ["teaser_text"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextBlock\Value)#4903 (1) {
          ["text"]=>
          string(206) "ACURATE neo shows
- Comparable procedural outcomes
- Lower new permanent pacemaker implantation rates

¹Husser, O. et al.; JACC: Cardiovascular Interventions. 10. 2078-2087. 10.1016/j.jcin.2017.06.026."
        }
      }
      ["is_menu_item"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4900 (1) {
          ["bool"]=>
          bool(false)
        }
      }
    }
    ["versionInfo":protected]=>
    object(eZ\Publish\Core\Repository\Values\Content\VersionInfo)#4899 (10) {
      ["names":protected]=>
      array(1) {
        ["eng-GB"]=>
        string(90) "ACURATE neo™ Aortic Valve System  shows safety & efficacy results comparable to SAPIEN 3"
      }
      ["contentInfo":protected]=>
      object(eZ\Publish\API\Repository\Values\Content\ContentInfo)#4705 (13) {
        ["id":protected]=>
        int(242519)
        ["contentTypeId":protected]=>
        int(52)
        ["name":protected]=>
        string(90) "ACURATE neo™ Aortic Valve System  shows safety & efficacy results comparable to SAPIEN 3"
        ["sectionId":protected]=>
        int(1)
        ["currentVersionNo":protected]=>
        int(31)
        ["published":protected]=>
        bool(true)
        ["ownerId":protected]=>
        int(143927)
        ["modificationDate":protected]=>
        object(DateTime)#4702 (3) {
          ["date"]=>
          string(26) "2018-01-15 14:19:09.000000"
          ["timezone_type"]=>
          int(3)
          ["timezone"]=>
          string(12) "Europe/Paris"
        }
        ["publishedDate":protected]=>
        object(DateTime)#4703 (3) {
          ["date"]=>
          string(26) "2017-12-22 10:24:31.000000"
          ["timezone_type"]=>
          int(3)
          ["timezone"]=>
          string(12) "Europe/Paris"
        }
        ["alwaysAvailable":protected]=>
        int(0)
        ["remoteId":protected]=>
        string(32) "664c53aeb2b4d54c3af1537920de4387"
        ["mainLanguageCode":protected]=>
        string(6) "eng-GB"
        ["mainLocationId":protected]=>
        string(6) "153814"
      }
      ["id":protected]=>
      int(717268)
      ["versionNo":protected]=>
      int(31)
      ["modificationDate":protected]=>
      object(DateTime)#4537 (3) {
        ["date"]=>
        string(26) "2018-01-15 14:19:09.000000"
        ["timezone_type"]=>
        int(3)
        ["timezone"]=>
        string(12) "Europe/Paris"
      }
      ["creatorId":protected]=>
      int(143927)
      ["creationDate":protected]=>
      object(DateTime)#4704 (3) {
        ["date"]=>
        string(26) "2018-01-15 14:18:59.000000"
        ["timezone_type"]=>
        int(3)
        ["timezone"]=>
        string(12) "Europe/Paris"
      }
      ["status":protected]=>
      int(1)
      ["initialLanguageCode":protected]=>
      string(6) "eng-GB"
      ["languageCodes":protected]=>
      array(1) {
        [0]=>
        string(6) "eng-GB"
      }
    }
    ["internalFields":"eZ\Publish\Core\Repository\Values\Content\Content":private]=>
    array(42) {
      [0]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4884 (4) {
        ["id":protected]=>
        int(5048791)
        ["fieldDefIdentifier":protected]=>
        string(5) "title"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4887 (1) {
          ["text"]=>
          string(90) "ACURATE neo™ Aortic Valve System  shows safety & efficacy results comparable to SAPIEN 3"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [1]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4712 (4) {
        ["id":protected]=>
        int(5048792)
        ["fieldDefIdentifier":protected]=>
        string(9) "url_title"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#5026 (1) {
          ["text"]=>
          string(0) ""
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [2]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#5086 (4) {
        ["id":protected]=>
        int(5048793)
        ["fieldDefIdentifier":protected]=>
        string(15) "visibility_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#5027 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [3]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4880 (4) {
        ["id":protected]=>
        int(5048794)
        ["fieldDefIdentifier":protected]=>
        string(10) "meta_title"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4881 (1) {
          ["text"]=>
          string(90) "ACURATE neo™ Aortic Valve System  shows safety & efficacy results comparable to SAPIEN 3"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [4]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4876 (4) {
        ["id":protected]=>
        int(5048795)
        ["fieldDefIdentifier":protected]=>
        string(16) "meta_description"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4879 (1) {
          ["text"]=>
          string(188) "Comparable performance for ACURATE neo and SAPIEN 3 with no significant differences at 30 days in safety outcomes, including the VARC-2 early safety and device failure composite endpoints."
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [5]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4878 (4) {
        ["id":protected]=>
        int(5048796)
        ["fieldDefIdentifier":protected]=>
        string(14) "classification"
        ["value":protected]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4873 (1) {
          ["tags"]=>
          array(2) {
            [0]=>
            object(Netgen\TagsBundle\API\Repository\Values\Tags\Tag)#4874 (8) {
              ["id":protected]=>
              string(3) "827"
              ["parentTagId":protected]=>
              string(3) "865"
              ["mainTagId":protected]=>
              string(1) "0"
              ["keyword":protected]=>
              string(4) "TAVI"
              ["depth":protected]=>
              string(1) "3"
              ["pathString":protected]=>
              string(13) "/861/865/827/"
              ["modificationDate":protected]=>
              object(DateTime)#4877 (3) {
                ["date"]=>
                string(26) "2016-10-27 16:43:43.000000"
                ["timezone_type"]=>
                int(3)
                ["timezone"]=>
                string(12) "Europe/Paris"
              }
              ["remoteId":protected]=>
              string(32) "615bb11c7415503edb26cddd0dd14a51"
            }
            [1]=>
            object(Netgen\TagsBundle\API\Repository\Values\Tags\Tag)#4872 (8) {
              ["id":protected]=>
              string(3) "865"
              ["parentTagId":protected]=>
              string(3) "861"
              ["mainTagId":protected]=>
              string(1) "0"
              ["keyword":protected]=>
              string(34) "Interventions for Valvular Disease"
              ["depth":protected]=>
              string(1) "2"
              ["pathString":protected]=>
              string(9) "/861/865/"
              ["modificationDate":protected]=>
              object(DateTime)#4875 (3) {
                ["date"]=>
                string(26) "2016-10-27 16:43:43.000000"
                ["timezone_type"]=>
                int(3)
                ["timezone"]=>
                string(12) "Europe/Paris"
              }
              ["remoteId":protected]=>
              string(32) "3aa2059f04b260b8b6f5f6b45a612d37"
            }
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [6]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4870 (4) {
        ["id":protected]=>
        int(5048797)
        ["fieldDefIdentifier":protected]=>
        string(8) "focus_on"
        ["value":protected]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4871 (1) {
          ["tags"]=>
          array(0) {
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [7]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4868 (4) {
        ["id":protected]=>
        int(5048798)
        ["fieldDefIdentifier":protected]=>
        string(9) "free_tags"
        ["value":protected]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4869 (1) {
          ["tags"]=>
          array(0) {
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [8]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4866 (4) {
        ["id":protected]=>
        int(5048799)
        ["fieldDefIdentifier":protected]=>
        string(4) "date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4867 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [9]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4864 (4) {
        ["id":protected]=>
        int(5048800)
        ["fieldDefIdentifier":protected]=>
        string(8) "subtitle"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4865 (1) {
          ["text"]=>
          string(30) "Sponsored by Boston Scientific"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [10]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4862 (4) {
        ["id":protected]=>
        int(5048801)
        ["fieldDefIdentifier":protected]=>
        string(5) "image"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Image\Value)#4863 (9) {
          ["id"]=>
          NULL
          ["alternativeText"]=>
          NULL
          ["fileName"]=>
          NULL
          ["fileSize"]=>
          NULL
          ["uri"]=>
          NULL
          ["imageId"]=>
          NULL
          ["inputUri"]=>
          NULL
          ["width"]=>
          NULL
          ["height"]=>
          NULL
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [11]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4860 (4) {
        ["id":protected]=>
        int(5048802)
        ["fieldDefIdentifier":protected]=>
        string(8) "top_text"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4861 (1) {
          ["xml"]=>
          object(DOMDocument)#4885 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(968) "Multi-centre propensity-matched comparison study1 between ACURATE neo Aortic Valve System and Edwards SAPIEN 3 Transcatheter Heart Valve, published in October’s edition of the Journal of the American College of Cardiology (JACC) shows comparable procedural outcomes:Observational, propensity-matched multicenter comparison of ACURATE neo and SAPIEN 3 from 3 high volume centers in Germany (DHZ Munich, UK Regensburg, Kerckhoff Klinikum Bad Nauheim)1,121 consecutive patients between Jan. 2014 and Jan. 2016 with symptomatic, severe stenosis of the native aortic valve treated with transfemoral TAVI using ACURATE neo (n = 311) or SAPIEN 3 (n = 810)To increase statistical power, a 1-to-2 nearest neighbor matching was used to identify 2 control cases treated with SAPIEN 3 (n = 622) for each case treated with ACURATE neo (n = 311)Endpoints: device failure and early safety composite endpoint at 30 days according to VARC-2 criteriaView full JACC publication "
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [12]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4858 (4) {
        ["id":protected]=>
        int(5048803)
        ["fieldDefIdentifier":protected]=>
        string(9) "main_text"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4859 (1) {
          ["xml"]=>
          object(DOMDocument)#4883 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(852) "Key facts highlighted in the study:Comparable performance for ACURATE neo and SAPIEN 3 with no significant differences at 30 days in safety outcomes, including the VARC-2 early safety and device failure composite endpoints.*Download publication summary © Europa Group – Original recording at PCR London Valves 2017References* Comparable VARC-2 device failure composite endpoint with ACURATE neo versus SAPIEN 3 (10.9% vs. 9.6%, p=n.s.) and early safety composite endpoint (15.8% vs. 15.6%, p=n.s.).** According to VARC-2, elevated gradients >20 mmHg are defined as mild stenosis, are assessed as Device Failure and may indicate prosthetic valve dysfunction.Husser O, et al. Multicenter comparison of novel self-expanding versus balloon-expandable transcatheter heart valves. JACC Cardiovasc Interv. 2017 Oct 23;10(20):2078-2087.SH-512201-AA NOV2017"
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [13]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4856 (4) {
        ["id":protected]=>
        int(5048804)
        ["fieldDefIdentifier":protected]=>
        string(18) "sponsor_disclaimer"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4857 (1) {
          ["text"]=>
          string(61) "With an unrestricted educational grant from Boston Scientific"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [14]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4854 (4) {
        ["id":protected]=>
        int(5048805)
        ["fieldDefIdentifier":protected]=>
        string(8) "partners"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\RelationList\Value)#4855 (1) {
          ["destinationContentIds"]=>
          array(1) {
            [0]=>
            int(246832)
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [15]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4852 (4) {
        ["id":protected]=>
        int(5048806)
        ["fieldDefIdentifier":protected]=>
        string(12) "contributors"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\RelationList\Value)#4853 (1) {
          ["destinationContentIds"]=>
          array(0) {
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [16]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4850 (4) {
        ["id":protected]=>
        int(5048807)
        ["fieldDefIdentifier":protected]=>
        string(16) "alt_contributors"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4851 (1) {
          ["xml"]=>
          object(DOMDocument)#4882 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(0) ""
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [17]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4848 (4) {
        ["id":protected]=>
        int(5048808)
        ["fieldDefIdentifier":protected]=>
        string(15) "enable_comments"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4849 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [18]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4846 (4) {
        ["id":protected]=>
        int(5048809)
        ["fieldDefIdentifier":protected]=>
        string(15) "show_disclaimer"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4847 (1) {
          ["bool"]=>
          bool(true)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [19]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4844 (4) {
        ["id":protected]=>
        int(5048810)
        ["fieldDefIdentifier":protected]=>
        string(15) "redirect_to_url"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Url\Value)#4845 (2) {
          ["link"]=>
          NULL
          ["text"]=>
          NULL
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [20]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4842 (4) {
        ["id":protected]=>
        int(5048811)
        ["fieldDefIdentifier":protected]=>
        string(18) "redirect_to_object"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Relation\Value)#4843 (1) {
          ["destinationContentId"]=>
          NULL
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [21]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4840 (4) {
        ["id":protected]=>
        int(5048812)
        ["fieldDefIdentifier":protected]=>
        string(26) "hide_related_content_block"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4841 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(2)
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [22]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4838 (4) {
        ["id":protected]=>
        int(5048813)
        ["fieldDefIdentifier":protected]=>
        string(27) "hide_promoted_content_block"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4839 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(2)
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [23]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4834 (4) {
        ["id":protected]=>
        int(5048814)
        ["fieldDefIdentifier":protected]=>
        string(30) "hide_recommended_content_block"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4837 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(2)
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [24]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4833 (4) {
        ["id":protected]=>
        int(5048815)
        ["fieldDefIdentifier":protected]=>
        string(7) "is_news"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4835 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [25]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4836 (4) {
        ["id":protected]=>
        int(5048816)
        ["fieldDefIdentifier":protected]=>
        string(18) "is_news_start_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4831 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [26]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4832 (4) {
        ["id":protected]=>
        int(5048817)
        ["fieldDefIdentifier":protected]=>
        string(23) "is_news_expiration_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4827 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [27]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4830 (4) {
        ["id":protected]=>
        int(5048818)
        ["fieldDefIdentifier":protected]=>
        string(15) "allowed_in_home"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4829 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [28]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4828 (4) {
        ["id":protected]=>
        int(5048819)
        ["fieldDefIdentifier":protected]=>
        string(26) "allowed_in_home_start_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4821 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [29]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4826 (4) {
        ["id":protected]=>
        int(5048820)
        ["fieldDefIdentifier":protected]=>
        string(31) "allowed_in_home_expiration_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4825 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [30]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4824 (4) {
        ["id":protected]=>
        int(5048821)
        ["fieldDefIdentifier":protected]=>
        string(14) "is_recommended"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4823 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [31]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4822 (4) {
        ["id":protected]=>
        int(5048822)
        ["fieldDefIdentifier":protected]=>
        string(25) "is_recommended_start_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4815 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [32]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4820 (4) {
        ["id":protected]=>
        int(5048823)
        ["fieldDefIdentifier":protected]=>
        string(30) "is_recommended_expiration_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4819 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [33]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4818 (4) {
        ["id":protected]=>
        int(5048824)
        ["fieldDefIdentifier":protected]=>
        string(11) "is_promoted"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4817 (1) {
          ["bool"]=>
          bool(true)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [34]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4816 (4) {
        ["id":protected]=>
        int(5048825)
        ["fieldDefIdentifier":protected]=>
        string(22) "is_promoted_start_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4814 (2) {
          ["date"]=>
          object(DateTime)#4811 (3) {
            ["date"]=>
            string(26) "2018-01-11 00:00:00.000000"
            ["timezone_type"]=>
            int(3)
            ["timezone"]=>
            string(12) "Europe/Paris"
          }
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [35]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4813 (4) {
        ["id":protected]=>
        int(5048826)
        ["fieldDefIdentifier":protected]=>
        string(27) "is_promoted_expiration_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4809 (2) {
          ["date"]=>
          object(DateTime)#4810 (3) {
            ["date"]=>
            string(26) "2018-12-31 00:00:00.000000"
            ["timezone_type"]=>
            int(3)
            ["timezone"]=>
            string(12) "Europe/Paris"
          }
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [36]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4812 (4) {
        ["id":protected]=>
        int(5048827)
        ["fieldDefIdentifier":protected]=>
        string(19) "show_promoted_label"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4807 (1) {
          ["bool"]=>
          bool(true)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [37]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4808 (4) {
        ["id":protected]=>
        int(5048828)
        ["fieldDefIdentifier":protected]=>
        string(12) "do_not_index"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4805 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [38]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4806 (4) {
        ["id":protected]=>
        int(5048829)
        ["fieldDefIdentifier":protected]=>
        string(12) "teaser_image"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Image\Value)#4803 (9) {
          ["id"]=>
          string(276) "pcronline/cases-resources-images/industry-partner-perspectives/promoted-content/2017/acurate-neo-aortic-valve-system-shows-safety-efficacy-results-comparable-to-sapien-3/5048829-29-eng-GB/ACURATE-neo-Aortic-Valve-System-shows-safety-efficacy-results-comparable-to-SAPIEN-3.jpg"
          ["alternativeText"]=>
          string(90) "ACURATE neo™ Aortic Valve System  shows safety & efficacy results comparable to SAPIEN 3"
          ["fileName"]=>
          string(88) "ACURATE-neo-Aortic-Valve-System-shows-safety-efficacy-results-comparable-to-SAPIEN-3.jpg"
          ["fileSize"]=>
          int(25246)
          ["uri"]=>
          string(303) "/var/pcrov3/storage/images/pcronline/cases-resources-images/industry-partner-perspectives/promoted-content/2017/acurate-neo-aortic-valve-system-shows-safety-efficacy-results-comparable-to-sapien-3/5048829-29-eng-GB/ACURATE-neo-Aortic-Valve-System-shows-safety-efficacy-results-comparable-to-SAPIEN-3.jpg"
          ["imageId"]=>
          string(14) "242519-5048829"
          ["inputUri"]=>
          NULL
          ["width"]=>
          string(3) "448"
          ["height"]=>
          string(3) "220"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [39]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4804 (4) {
        ["id":protected]=>
        int(5048830)
        ["fieldDefIdentifier":protected]=>
        string(12) "teaser_title"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4898 (1) {
          ["text"]=>
          string(91) "ACURATE neo™ Aortic Valve System shows safety & efficacy results comparable to SAPIEN 3¹"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [40]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4901 (4) {
        ["id":protected]=>
        int(5048831)
        ["fieldDefIdentifier":protected]=>
        string(11) "teaser_text"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextBlock\Value)#4903 (1) {
          ["text"]=>
          string(206) "ACURATE neo shows
- Comparable procedural outcomes
- Lower new permanent pacemaker implantation rates

¹Husser, O. et al.; JACC: Cardiovascular Interventions. 10. 2078-2087. 10.1016/j.jcin.2017.06.026."
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [41]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4902 (4) {
        ["id":protected]=>
        int(5048832)
        ["fieldDefIdentifier":protected]=>
        string(12) "is_menu_item"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4900 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
    }
  }
  [144920]=>
  object(eZ\Publish\Core\Repository\Values\Content\Content)#4700 (3) {
    ["fields":protected]=>
    array(42) {
      ["title"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4523 (1) {
          ["text"]=>
          string(102) "Explore the SOURCE 3 Registry: Real-World Evidence With the Edwards SAPIEN 3 Transcatheter Heart Valve"
        }
      }
      ["url_title"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4521 (1) {
          ["text"]=>
          string(0) ""
        }
      }
      ["visibility_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4519 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["meta_title"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4517 (1) {
          ["text"]=>
          string(102) "Explore the SOURCE 3 Registry: Real-World Evidence with the Edwards SAPIEN 3 Transcatheter Heart Valve"
        }
      }
      ["meta_description"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4515 (1) {
          ["text"]=>
          string(220) "At EuroPCR 2017, new one-year data from a post-approval study of the Edwards SAPIEN 3 valve demonstrated positive patient outcomes, including high survival rates, low rates of stroke, and low rates of paravalvular leak. "
        }
      }
      ["classification"]=>
      array(1) {
        ["eng-GB"]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4509 (1) {
          ["tags"]=>
          array(2) {
            [0]=>
            object(Netgen\TagsBundle\API\Repository\Values\Tags\Tag)#4514 (8) {
              ["id":protected]=>
              string(3) "827"
              ["parentTagId":protected]=>
              string(3) "865"
              ["mainTagId":protected]=>
              string(1) "0"
              ["keyword":protected]=>
              string(4) "TAVI"
              ["depth":protected]=>
              string(1) "3"
              ["pathString":protected]=>
              string(13) "/861/865/827/"
              ["modificationDate":protected]=>
              object(DateTime)#4513 (3) {
                ["date"]=>
                string(26) "2016-10-27 16:43:43.000000"
                ["timezone_type"]=>
                int(3)
                ["timezone"]=>
                string(12) "Europe/Paris"
              }
              ["remoteId":protected]=>
              string(32) "615bb11c7415503edb26cddd0dd14a51"
            }
            [1]=>
            object(Netgen\TagsBundle\API\Repository\Values\Tags\Tag)#4512 (8) {
              ["id":protected]=>
              string(3) "865"
              ["parentTagId":protected]=>
              string(3) "861"
              ["mainTagId":protected]=>
              string(1) "0"
              ["keyword":protected]=>
              string(34) "Interventions for Valvular Disease"
              ["depth":protected]=>
              string(1) "2"
              ["pathString":protected]=>
              string(9) "/861/865/"
              ["modificationDate":protected]=>
              object(DateTime)#4511 (3) {
                ["date"]=>
                string(26) "2016-10-27 16:43:43.000000"
                ["timezone_type"]=>
                int(3)
                ["timezone"]=>
                string(12) "Europe/Paris"
              }
              ["remoteId":protected]=>
              string(32) "3aa2059f04b260b8b6f5f6b45a612d37"
            }
          }
        }
      }
      ["focus_on"]=>
      array(1) {
        ["eng-GB"]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4507 (1) {
          ["tags"]=>
          array(0) {
          }
        }
      }
      ["free_tags"]=>
      array(1) {
        ["eng-GB"]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4505 (1) {
          ["tags"]=>
          array(0) {
          }
        }
      }
      ["date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4501 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["subtitle"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4498 (1) {
          ["text"]=>
          string(33) "Sponsored by Edwards Lifesciences"
        }
      }
      ["image"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Image\Value)#4503 (9) {
          ["id"]=>
          NULL
          ["alternativeText"]=>
          NULL
          ["fileName"]=>
          NULL
          ["fileSize"]=>
          NULL
          ["uri"]=>
          NULL
          ["imageId"]=>
          NULL
          ["inputUri"]=>
          NULL
          ["width"]=>
          NULL
          ["height"]=>
          NULL
        }
      }
      ["top_text"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4499 (1) {
          ["xml"]=>
          object(DOMDocument)#4527 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(525) "At EuroPCR 2017, new one-year data from a post-approval study of the Edwards SAPIEN 3 valve demonstrated positive patient outcomes, including high survival rates, low rates of stroke, and low rates of paravalvular leak.The majority of patients in the SOURCE 3 Registry were treated via transfemoral access, and more than half were treated under conscious sedation. SOURCE 3 patients were enrolled at 80 centres across 10 countries between July 2014 and October 2015, and will continue to be followed for five years post-TAVI."
          }
        }
      }
      ["main_text"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4495 (1) {
          ["xml"]=>
          object(DOMDocument)#4528 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(1869) "SOURCE 3 post-approval registry—One-year outcomes in 1,946 TAVI patients with a 3rd generation balloon transcatheter heart valve Speaker: O. WendlerAt 1 year, patients treated via the transfemoral access route had a high survival rate (88.2 percent) and a low disabling stroke rate (1.1 percent).Patients experienced a low rate (2.7 percent) of moderate paravalvular leak and no severe paravalvular leak. Watch the presentationCharacteristics and outcomes of patients ≤75 years old undergoing TAVI—Insights from the SOURCE 3 registry Speaker: D. FrankRead the presentationSurgical risk and outcomes of patients undergoing TAVI with the Edwards SAPIEN 3 bioprosthesis: A subanalysis of the SOURCE 3 registry Speaker: G. TarantiniRead the presentation TAVI with the Edwards SAPIEN 3TM Valve Visit SAPIEN3.com  to see how SAPIEN 3 TAVI is transforming treatment today.For professional use. See instructions for use for full prescribing information, including indications, contraindications, warnings, precautions, and adverse events.Edwards Lifesciences devices placed on the European market meeting the essential requirements referred to in Article 3 of the Medical Device Directive 93/42/EEC bear the CE marking of conformity.Material for distribution only in countries with applicable health authority product registrations. Material not intended for distribution in USA or Japan. Indications, contraindications, warnings, and instructions for use can be found in the product labeling supplied with each device.Edwards, Edwards Lifesciences, the stylized E logo, Edwards SAPIEN, Edwards SAPIEN 3, PARTNER, PARTNER II, SAPIEN, and SAPIEN 3 are trademarks of Edwards Lifesciences Corporation.© 2017 Edwards Lifesciences Corporation. All rights reserved. E7165/07-17/THVEdwards Lifesciences • Route de l’Etraz 70, 1260 Nyon, Switzerland • edwards.com"
          }
        }
      }
      ["sponsor_disclaimer"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4493 (1) {
          ["text"]=>
          string(64) "With an unrestricted educational grant from Edwards Lifesciences"
        }
      }
      ["partners"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\RelationList\Value)#4491 (1) {
          ["destinationContentIds"]=>
          array(1) {
            [0]=>
            int(234869)
          }
        }
      }
      ["contributors"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\RelationList\Value)#4489 (1) {
          ["destinationContentIds"]=>
          array(0) {
          }
        }
      }
      ["alt_contributors"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4487 (1) {
          ["xml"]=>
          object(DOMDocument)#4525 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(0) ""
          }
        }
      }
      ["enable_comments"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4485 (1) {
          ["bool"]=>
          bool(false)
        }
      }
      ["show_disclaimer"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4483 (1) {
          ["bool"]=>
          bool(true)
        }
      }
      ["redirect_to_url"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Url\Value)#4481 (2) {
          ["link"]=>
          string(0) ""
          ["text"]=>
          string(0) ""
        }
      }
      ["redirect_to_object"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Relation\Value)#4479 (1) {
          ["destinationContentId"]=>
          NULL
        }
      }
      ["hide_related_content_block"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4477 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(1)
          }
        }
      }
      ["hide_promoted_content_block"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4475 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(1)
          }
        }
      }
      ["hide_recommended_content_block"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4473 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(1)
          }
        }
      }
      ["is_news"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4471 (1) {
          ["bool"]=>
          bool(false)
        }
      }
      ["is_news_start_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4469 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["is_news_expiration_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4467 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["allowed_in_home"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4465 (1) {
          ["bool"]=>
          bool(false)
        }
      }
      ["allowed_in_home_start_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4463 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["allowed_in_home_expiration_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4459 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["is_recommended"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4461 (1) {
          ["bool"]=>
          bool(false)
        }
      }
      ["is_recommended_start_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4455 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["is_recommended_expiration_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4457 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["is_promoted"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4443 (1) {
          ["bool"]=>
          bool(true)
        }
      }
      ["is_promoted_start_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4452 (2) {
          ["date"]=>
          object(DateTime)#4451 (3) {
            ["date"]=>
            string(26) "2018-01-08 00:00:00.000000"
            ["timezone_type"]=>
            int(3)
            ["timezone"]=>
            string(12) "Europe/Paris"
          }
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["is_promoted_expiration_date"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4449 (2) {
          ["date"]=>
          object(DateTime)#4448 (3) {
            ["date"]=>
            string(26) "2018-12-31 00:00:00.000000"
            ["timezone_type"]=>
            int(3)
            ["timezone"]=>
            string(12) "Europe/Paris"
          }
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
      }
      ["show_promoted_label"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4447 (1) {
          ["bool"]=>
          bool(true)
        }
      }
      ["do_not_index"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4445 (1) {
          ["bool"]=>
          bool(false)
        }
      }
      ["teaser_image"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Image\Value)#4441 (9) {
          ["id"]=>
          string(310) "pcronline/cases-resources-images/industry-partner-perspectives/promoted-content/2017/explore-the-source-3-registry-real-world-evidence-with-the-edwards-sapien-3-transcatheter-heart-valve/3948952-55-eng-GB/Explore-the-SOURCE-3-Registry-Real-World-Evidence-With-the-Edwards-SAPIEN-3-Transcatheter-Heart-Valve.jpg"
          ["alternativeText"]=>
          string(50) "SOURCE 3 Update: New real-world SAPIEN 3 TAVI data"
          ["fileName"]=>
          string(105) "Explore-the-SOURCE-3-Registry-Real-World-Evidence-With-the-Edwards-SAPIEN-3-Transcatheter-Heart-Valve.jpg"
          ["fileSize"]=>
          int(52491)
          ["uri"]=>
          string(337) "/var/pcrov3/storage/images/pcronline/cases-resources-images/industry-partner-perspectives/promoted-content/2017/explore-the-source-3-registry-real-world-evidence-with-the-edwards-sapien-3-transcatheter-heart-valve/3948952-55-eng-GB/Explore-the-SOURCE-3-Registry-Real-World-Evidence-With-the-Edwards-SAPIEN-3-Transcatheter-Heart-Valve.jpg"
          ["imageId"]=>
          string(14) "197188-3948952"
          ["inputUri"]=>
          NULL
          ["width"]=>
          string(3) "640"
          ["height"]=>
          string(3) "314"
        }
      }
      ["teaser_title"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4439 (1) {
          ["text"]=>
          string(50) "SOURCE 3 Update: New real-world SAPIEN 3 TAVI data"
        }
      }
      ["teaser_text"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\TextBlock\Value)#4437 (1) {
          ["text"]=>
          string(149) "Learn about new data from the SOURCE 3 Registry, presented at EuroPCR 2017, on patients treated with the Edwards SAPIEN 3 Transcatheter Heart Valve. "
        }
      }
      ["is_menu_item"]=>
      array(1) {
        ["eng-GB"]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4435 (1) {
          ["bool"]=>
          bool(false)
        }
      }
    }
    ["versionInfo":protected]=>
    object(eZ\Publish\Core\Repository\Values\Content\VersionInfo)#4436 (10) {
      ["names":protected]=>
      array(1) {
        ["eng-GB"]=>
        string(102) "Explore the SOURCE 3 Registry: Real-World Evidence With the Edwards SAPIEN 3 Transcatheter Heart Valve"
      }
      ["contentInfo":protected]=>
      object(eZ\Publish\API\Repository\Values\Content\ContentInfo)#4431 (13) {
        ["id":protected]=>
        int(197188)
        ["contentTypeId":protected]=>
        int(52)
        ["name":protected]=>
        string(102) "Explore the SOURCE 3 Registry: Real-World Evidence With the Edwards SAPIEN 3 Transcatheter Heart Valve"
        ["sectionId":protected]=>
        int(1)
        ["currentVersionNo":protected]=>
        int(67)
        ["published":protected]=>
        bool(true)
        ["ownerId":protected]=>
        int(143927)
        ["modificationDate":protected]=>
        object(DateTime)#4432 (3) {
          ["date"]=>
          string(26) "2018-01-15 14:30:15.000000"
          ["timezone_type"]=>
          int(3)
          ["timezone"]=>
          string(12) "Europe/Paris"
        }
        ["publishedDate":protected]=>
        object(DateTime)#4531 (3) {
          ["date"]=>
          string(26) "2017-07-28 14:42:20.000000"
          ["timezone_type"]=>
          int(3)
          ["timezone"]=>
          string(12) "Europe/Paris"
        }
        ["alwaysAvailable":protected]=>
        int(0)
        ["remoteId":protected]=>
        string(32) "e680f84dc3da2cd0e4d6dd8c5b4c8117"
        ["mainLanguageCode":protected]=>
        string(6) "eng-GB"
        ["mainLocationId":protected]=>
        string(6) "144920"
      }
      ["id":protected]=>
      int(717278)
      ["versionNo":protected]=>
      int(67)
      ["modificationDate":protected]=>
      object(DateTime)#4433 (3) {
        ["date"]=>
        string(26) "2018-01-15 14:30:15.000000"
        ["timezone_type"]=>
        int(3)
        ["timezone"]=>
        string(12) "Europe/Paris"
      }
      ["creatorId":protected]=>
      int(14)
      ["creationDate":protected]=>
      object(DateTime)#4434 (3) {
        ["date"]=>
        string(26) "2018-01-15 14:30:14.000000"
        ["timezone_type"]=>
        int(3)
        ["timezone"]=>
        string(12) "Europe/Paris"
      }
      ["status":protected]=>
      int(1)
      ["initialLanguageCode":protected]=>
      string(6) "eng-GB"
      ["languageCodes":protected]=>
      array(1) {
        [0]=>
        string(6) "eng-GB"
      }
    }
    ["internalFields":"eZ\Publish\Core\Repository\Values\Content\Content":private]=>
    array(42) {
      [0]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4526 (4) {
        ["id":protected]=>
        int(3948914)
        ["fieldDefIdentifier":protected]=>
        string(5) "title"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4523 (1) {
          ["text"]=>
          string(102) "Explore the SOURCE 3 Registry: Real-World Evidence With the Edwards SAPIEN 3 Transcatheter Heart Valve"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [1]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4524 (4) {
        ["id":protected]=>
        int(3948915)
        ["fieldDefIdentifier":protected]=>
        string(9) "url_title"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4521 (1) {
          ["text"]=>
          string(0) ""
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [2]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4522 (4) {
        ["id":protected]=>
        int(3948916)
        ["fieldDefIdentifier":protected]=>
        string(15) "visibility_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4519 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [3]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4520 (4) {
        ["id":protected]=>
        int(3948917)
        ["fieldDefIdentifier":protected]=>
        string(10) "meta_title"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4517 (1) {
          ["text"]=>
          string(102) "Explore the SOURCE 3 Registry: Real-World Evidence with the Edwards SAPIEN 3 Transcatheter Heart Valve"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [4]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4518 (4) {
        ["id":protected]=>
        int(3948918)
        ["fieldDefIdentifier":protected]=>
        string(16) "meta_description"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4515 (1) {
          ["text"]=>
          string(220) "At EuroPCR 2017, new one-year data from a post-approval study of the Edwards SAPIEN 3 valve demonstrated positive patient outcomes, including high survival rates, low rates of stroke, and low rates of paravalvular leak. "
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [5]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4516 (4) {
        ["id":protected]=>
        int(3948919)
        ["fieldDefIdentifier":protected]=>
        string(14) "classification"
        ["value":protected]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4509 (1) {
          ["tags"]=>
          array(2) {
            [0]=>
            object(Netgen\TagsBundle\API\Repository\Values\Tags\Tag)#4514 (8) {
              ["id":protected]=>
              string(3) "827"
              ["parentTagId":protected]=>
              string(3) "865"
              ["mainTagId":protected]=>
              string(1) "0"
              ["keyword":protected]=>
              string(4) "TAVI"
              ["depth":protected]=>
              string(1) "3"
              ["pathString":protected]=>
              string(13) "/861/865/827/"
              ["modificationDate":protected]=>
              object(DateTime)#4513 (3) {
                ["date"]=>
                string(26) "2016-10-27 16:43:43.000000"
                ["timezone_type"]=>
                int(3)
                ["timezone"]=>
                string(12) "Europe/Paris"
              }
              ["remoteId":protected]=>
              string(32) "615bb11c7415503edb26cddd0dd14a51"
            }
            [1]=>
            object(Netgen\TagsBundle\API\Repository\Values\Tags\Tag)#4512 (8) {
              ["id":protected]=>
              string(3) "865"
              ["parentTagId":protected]=>
              string(3) "861"
              ["mainTagId":protected]=>
              string(1) "0"
              ["keyword":protected]=>
              string(34) "Interventions for Valvular Disease"
              ["depth":protected]=>
              string(1) "2"
              ["pathString":protected]=>
              string(9) "/861/865/"
              ["modificationDate":protected]=>
              object(DateTime)#4511 (3) {
                ["date"]=>
                string(26) "2016-10-27 16:43:43.000000"
                ["timezone_type"]=>
                int(3)
                ["timezone"]=>
                string(12) "Europe/Paris"
              }
              ["remoteId":protected]=>
              string(32) "3aa2059f04b260b8b6f5f6b45a612d37"
            }
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [6]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4510 (4) {
        ["id":protected]=>
        int(3948920)
        ["fieldDefIdentifier":protected]=>
        string(8) "focus_on"
        ["value":protected]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4507 (1) {
          ["tags"]=>
          array(0) {
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [7]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4508 (4) {
        ["id":protected]=>
        int(3948921)
        ["fieldDefIdentifier":protected]=>
        string(9) "free_tags"
        ["value":protected]=>
        object(Netgen\TagsBundle\Core\FieldType\Tags\Value)#4505 (1) {
          ["tags"]=>
          array(0) {
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [8]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4506 (4) {
        ["id":protected]=>
        int(3948922)
        ["fieldDefIdentifier":protected]=>
        string(4) "date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4501 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [9]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4504 (4) {
        ["id":protected]=>
        int(3948923)
        ["fieldDefIdentifier":protected]=>
        string(8) "subtitle"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4498 (1) {
          ["text"]=>
          string(33) "Sponsored by Edwards Lifesciences"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [10]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4502 (4) {
        ["id":protected]=>
        int(3948924)
        ["fieldDefIdentifier":protected]=>
        string(5) "image"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Image\Value)#4503 (9) {
          ["id"]=>
          NULL
          ["alternativeText"]=>
          NULL
          ["fileName"]=>
          NULL
          ["fileSize"]=>
          NULL
          ["uri"]=>
          NULL
          ["imageId"]=>
          NULL
          ["inputUri"]=>
          NULL
          ["width"]=>
          NULL
          ["height"]=>
          NULL
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [11]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4497 (4) {
        ["id":protected]=>
        int(3948925)
        ["fieldDefIdentifier":protected]=>
        string(8) "top_text"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4499 (1) {
          ["xml"]=>
          object(DOMDocument)#4527 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(525) "At EuroPCR 2017, new one-year data from a post-approval study of the Edwards SAPIEN 3 valve demonstrated positive patient outcomes, including high survival rates, low rates of stroke, and low rates of paravalvular leak.The majority of patients in the SOURCE 3 Registry were treated via transfemoral access, and more than half were treated under conscious sedation. SOURCE 3 patients were enrolled at 80 centres across 10 countries between July 2014 and October 2015, and will continue to be followed for five years post-TAVI."
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [12]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4500 (4) {
        ["id":protected]=>
        int(3948926)
        ["fieldDefIdentifier":protected]=>
        string(9) "main_text"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4495 (1) {
          ["xml"]=>
          object(DOMDocument)#4528 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(1869) "SOURCE 3 post-approval registry—One-year outcomes in 1,946 TAVI patients with a 3rd generation balloon transcatheter heart valve Speaker: O. WendlerAt 1 year, patients treated via the transfemoral access route had a high survival rate (88.2 percent) and a low disabling stroke rate (1.1 percent).Patients experienced a low rate (2.7 percent) of moderate paravalvular leak and no severe paravalvular leak. Watch the presentationCharacteristics and outcomes of patients ≤75 years old undergoing TAVI—Insights from the SOURCE 3 registry Speaker: D. FrankRead the presentationSurgical risk and outcomes of patients undergoing TAVI with the Edwards SAPIEN 3 bioprosthesis: A subanalysis of the SOURCE 3 registry Speaker: G. TarantiniRead the presentation TAVI with the Edwards SAPIEN 3TM Valve Visit SAPIEN3.com  to see how SAPIEN 3 TAVI is transforming treatment today.For professional use. See instructions for use for full prescribing information, including indications, contraindications, warnings, precautions, and adverse events.Edwards Lifesciences devices placed on the European market meeting the essential requirements referred to in Article 3 of the Medical Device Directive 93/42/EEC bear the CE marking of conformity.Material for distribution only in countries with applicable health authority product registrations. Material not intended for distribution in USA or Japan. Indications, contraindications, warnings, and instructions for use can be found in the product labeling supplied with each device.Edwards, Edwards Lifesciences, the stylized E logo, Edwards SAPIEN, Edwards SAPIEN 3, PARTNER, PARTNER II, SAPIEN, and SAPIEN 3 are trademarks of Edwards Lifesciences Corporation.© 2017 Edwards Lifesciences Corporation. All rights reserved. E7165/07-17/THVEdwards Lifesciences • Route de l’Etraz 70, 1260 Nyon, Switzerland • edwards.com"
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [13]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4496 (4) {
        ["id":protected]=>
        int(3948927)
        ["fieldDefIdentifier":protected]=>
        string(18) "sponsor_disclaimer"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4493 (1) {
          ["text"]=>
          string(64) "With an unrestricted educational grant from Edwards Lifesciences"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [14]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4494 (4) {
        ["id":protected]=>
        int(3948928)
        ["fieldDefIdentifier":protected]=>
        string(8) "partners"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\RelationList\Value)#4491 (1) {
          ["destinationContentIds"]=>
          array(1) {
            [0]=>
            int(234869)
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [15]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4492 (4) {
        ["id":protected]=>
        int(3948929)
        ["fieldDefIdentifier":protected]=>
        string(12) "contributors"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\RelationList\Value)#4489 (1) {
          ["destinationContentIds"]=>
          array(0) {
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [16]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4490 (4) {
        ["id":protected]=>
        int(3948930)
        ["fieldDefIdentifier":protected]=>
        string(16) "alt_contributors"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\XmlText\Value)#4487 (1) {
          ["xml"]=>
          object(DOMDocument)#4525 (34) {
            ["doctype"]=>
            NULL
            ["implementation"]=>
            string(22) "(object value omitted)"
            ["documentElement"]=>
            string(22) "(object value omitted)"
            ["actualEncoding"]=>
            string(5) "utf-8"
            ["encoding"]=>
            string(5) "utf-8"
            ["xmlEncoding"]=>
            string(5) "utf-8"
            ["standalone"]=>
            bool(true)
            ["xmlStandalone"]=>
            bool(true)
            ["version"]=>
            string(3) "1.0"
            ["xmlVersion"]=>
            string(3) "1.0"
            ["strictErrorChecking"]=>
            bool(true)
            ["documentURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["config"]=>
            NULL
            ["formatOutput"]=>
            bool(false)
            ["validateOnParse"]=>
            bool(false)
            ["resolveExternals"]=>
            bool(false)
            ["preserveWhiteSpace"]=>
            bool(true)
            ["recover"]=>
            bool(false)
            ["substituteEntities"]=>
            bool(false)
            ["nodeName"]=>
            string(9) "#document"
            ["nodeValue"]=>
            NULL
            ["nodeType"]=>
            int(9)
            ["parentNode"]=>
            NULL
            ["childNodes"]=>
            string(22) "(object value omitted)"
            ["firstChild"]=>
            string(22) "(object value omitted)"
            ["lastChild"]=>
            string(22) "(object value omitted)"
            ["previousSibling"]=>
            NULL
            ["attributes"]=>
            NULL
            ["ownerDocument"]=>
            NULL
            ["namespaceURI"]=>
            NULL
            ["prefix"]=>
            string(0) ""
            ["localName"]=>
            NULL
            ["baseURI"]=>
            string(54) "/var/www/pcrov3/releases/prod_20171206/ezpublish5/web/"
            ["textContent"]=>
            string(0) ""
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [17]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4488 (4) {
        ["id":protected]=>
        int(3948931)
        ["fieldDefIdentifier":protected]=>
        string(15) "enable_comments"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4485 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [18]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4486 (4) {
        ["id":protected]=>
        int(3948932)
        ["fieldDefIdentifier":protected]=>
        string(15) "show_disclaimer"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4483 (1) {
          ["bool"]=>
          bool(true)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [19]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4484 (4) {
        ["id":protected]=>
        int(3948933)
        ["fieldDefIdentifier":protected]=>
        string(15) "redirect_to_url"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Url\Value)#4481 (2) {
          ["link"]=>
          string(0) ""
          ["text"]=>
          string(0) ""
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [20]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4482 (4) {
        ["id":protected]=>
        int(3948934)
        ["fieldDefIdentifier":protected]=>
        string(18) "redirect_to_object"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Relation\Value)#4479 (1) {
          ["destinationContentId"]=>
          NULL
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [21]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4480 (4) {
        ["id":protected]=>
        int(3948935)
        ["fieldDefIdentifier":protected]=>
        string(26) "hide_related_content_block"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4477 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(1)
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [22]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4478 (4) {
        ["id":protected]=>
        int(3948936)
        ["fieldDefIdentifier":protected]=>
        string(27) "hide_promoted_content_block"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4475 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(1)
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [23]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4476 (4) {
        ["id":protected]=>
        int(3948937)
        ["fieldDefIdentifier":protected]=>
        string(30) "hide_recommended_content_block"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Selection\Value)#4473 (1) {
          ["selection"]=>
          array(1) {
            [0]=>
            int(1)
          }
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [24]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4474 (4) {
        ["id":protected]=>
        int(3948938)
        ["fieldDefIdentifier":protected]=>
        string(7) "is_news"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4471 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [25]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4472 (4) {
        ["id":protected]=>
        int(3948939)
        ["fieldDefIdentifier":protected]=>
        string(18) "is_news_start_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4469 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [26]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4470 (4) {
        ["id":protected]=>
        int(3948940)
        ["fieldDefIdentifier":protected]=>
        string(23) "is_news_expiration_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4467 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [27]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4468 (4) {
        ["id":protected]=>
        int(3948941)
        ["fieldDefIdentifier":protected]=>
        string(15) "allowed_in_home"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4465 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [28]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4466 (4) {
        ["id":protected]=>
        int(3948942)
        ["fieldDefIdentifier":protected]=>
        string(26) "allowed_in_home_start_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4463 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [29]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4464 (4) {
        ["id":protected]=>
        int(3948943)
        ["fieldDefIdentifier":protected]=>
        string(31) "allowed_in_home_expiration_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4459 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [30]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4462 (4) {
        ["id":protected]=>
        int(3948944)
        ["fieldDefIdentifier":protected]=>
        string(14) "is_recommended"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4461 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [31]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4460 (4) {
        ["id":protected]=>
        int(3948945)
        ["fieldDefIdentifier":protected]=>
        string(25) "is_recommended_start_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4455 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [32]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4458 (4) {
        ["id":protected]=>
        int(3948946)
        ["fieldDefIdentifier":protected]=>
        string(30) "is_recommended_expiration_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4457 (2) {
          ["date"]=>
          NULL
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [33]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4456 (4) {
        ["id":protected]=>
        int(3948947)
        ["fieldDefIdentifier":protected]=>
        string(11) "is_promoted"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4443 (1) {
          ["bool"]=>
          bool(true)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [34]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4454 (4) {
        ["id":protected]=>
        int(3948948)
        ["fieldDefIdentifier":protected]=>
        string(22) "is_promoted_start_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4452 (2) {
          ["date"]=>
          object(DateTime)#4451 (3) {
            ["date"]=>
            string(26) "2018-01-08 00:00:00.000000"
            ["timezone_type"]=>
            int(3)
            ["timezone"]=>
            string(12) "Europe/Paris"
          }
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [35]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4453 (4) {
        ["id":protected]=>
        int(3948949)
        ["fieldDefIdentifier":protected]=>
        string(27) "is_promoted_expiration_date"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Date\Value)#4449 (2) {
          ["date"]=>
          object(DateTime)#4448 (3) {
            ["date"]=>
            string(26) "2018-12-31 00:00:00.000000"
            ["timezone_type"]=>
            int(3)
            ["timezone"]=>
            string(12) "Europe/Paris"
          }
          ["stringFormat"]=>
          string(7) "l d F Y"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [36]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4450 (4) {
        ["id":protected]=>
        int(3948950)
        ["fieldDefIdentifier":protected]=>
        string(19) "show_promoted_label"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4447 (1) {
          ["bool"]=>
          bool(true)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [37]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4446 (4) {
        ["id":protected]=>
        int(3948951)
        ["fieldDefIdentifier":protected]=>
        string(12) "do_not_index"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4445 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [38]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4444 (4) {
        ["id":protected]=>
        int(3948952)
        ["fieldDefIdentifier":protected]=>
        string(12) "teaser_image"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Image\Value)#4441 (9) {
          ["id"]=>
          string(310) "pcronline/cases-resources-images/industry-partner-perspectives/promoted-content/2017/explore-the-source-3-registry-real-world-evidence-with-the-edwards-sapien-3-transcatheter-heart-valve/3948952-55-eng-GB/Explore-the-SOURCE-3-Registry-Real-World-Evidence-With-the-Edwards-SAPIEN-3-Transcatheter-Heart-Valve.jpg"
          ["alternativeText"]=>
          string(50) "SOURCE 3 Update: New real-world SAPIEN 3 TAVI data"
          ["fileName"]=>
          string(105) "Explore-the-SOURCE-3-Registry-Real-World-Evidence-With-the-Edwards-SAPIEN-3-Transcatheter-Heart-Valve.jpg"
          ["fileSize"]=>
          int(52491)
          ["uri"]=>
          string(337) "/var/pcrov3/storage/images/pcronline/cases-resources-images/industry-partner-perspectives/promoted-content/2017/explore-the-source-3-registry-real-world-evidence-with-the-edwards-sapien-3-transcatheter-heart-valve/3948952-55-eng-GB/Explore-the-SOURCE-3-Registry-Real-World-Evidence-With-the-Edwards-SAPIEN-3-Transcatheter-Heart-Valve.jpg"
          ["imageId"]=>
          string(14) "197188-3948952"
          ["inputUri"]=>
          NULL
          ["width"]=>
          string(3) "640"
          ["height"]=>
          string(3) "314"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [39]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4442 (4) {
        ["id":protected]=>
        int(3948953)
        ["fieldDefIdentifier":protected]=>
        string(12) "teaser_title"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextLine\Value)#4439 (1) {
          ["text"]=>
          string(50) "SOURCE 3 Update: New real-world SAPIEN 3 TAVI data"
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [40]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4440 (4) {
        ["id":protected]=>
        int(3948954)
        ["fieldDefIdentifier":protected]=>
        string(11) "teaser_text"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\TextBlock\Value)#4437 (1) {
          ["text"]=>
          string(149) "Learn about new data from the SOURCE 3 Registry, presented at EuroPCR 2017, on patients treated with the Edwards SAPIEN 3 Transcatheter Heart Valve. "
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
      [41]=>
      object(eZ\Publish\API\Repository\Values\Content\Field)#4438 (4) {
        ["id":protected]=>
        int(3948955)
        ["fieldDefIdentifier":protected]=>
        string(12) "is_menu_item"
        ["value":protected]=>
        object(eZ\Publish\Core\FieldType\Checkbox\Value)#4435 (1) {
          ["bool"]=>
          bool(false)
        }
        ["languageCode":protected]=>
        string(6) "eng-GB"
      }
    }
  }
}