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EDITORIAL

Very late scaffold thrombosis: is prolonged DAPT the answer?

The New York Presbyterian Hospital, Columbia University Medical Center, and the Cardiovascular Research Foundation, New York, NY, USA

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Bioresorbable scaffolds (BRS) were developed as an alternative to metallic drug-eluting stents (DES) for use during percutaneous coronary intervention to overcome the lifelong risk of complications that arises from the permanent metallic implant long after the hazards of vessel recoil and constrictive remodelling have passed11. Kereiakes DJ, Onuma Y, Serruys PW, Stone GW. Bioresorbable Vascular Scaffolds for Coronary Revascularization. Circulation. 2016;134:168-82. . BRS also address other inadequacies of metallic DES, including the permanent jailing of side branches, the consequences of full metal jacket treatment of diffuse disease eliminating late surgical options, the detrimental space-occupying effects of an additional metal layer when treating in-stent restenosis, and blooming artefacts precluding use of CT imaging for non-invasive follow-up. However, for the long-term benefits of BRS to be realised (a yet unproven hypothesis being tested in the ABSORB IV trial with up to 10-year follow-up), BRS should ideally be as safe and effective as contemporary metallic DES within the first few years, until the time of their complete bioresorption. In this regard, randomised trials with the first and most widely used BRS, the poly-L-lactic acid (PLLA)-based everolimus-eluting Absorb BVS (Abbott Vascular, Santa Clara, CA, USA), have demonstrated increased rates of device-related adverse events within the first several years after implantation, compared to the cobalt-chromium everolimus-eluting XIENCE stent (also Abbott Vascular)22. Stone GW, Gao R, Kimura T, Kereiakes DJ, Ellis SG, Onuma Y, Cheong WF, Jones-McMeans J, Su X, Zhang Z, Serruys PW. 1-year outcomes with the Absorb bioresorbable scaffold in patients with coronary artery disease: a patient-level, pooled meta-analysis. Lancet. 2016;387:1277-89. ,33. Sorrentino S, Giustino G, Mehran R, Kini AS, Sharma SK, Faggioni M, Farhan S, Vogel B, Indolfi C, Dangas GD. Everolimus-Eluting Bioresorbable Scaffolds versus Metallic Everolimus-Eluting Stents: Meta-Analysis of Randomized Controlled Trials. J Am Coll Cardiol. 2017 Apr 12. [Epub ahead of print] ,44. Wykrzykowska JJ, Kraak RP, Hofma SH, van der Schaaf RJ, Arkenbout EK, IJsselmuiden AJ, Elias J, van Dongen IM, Tijssen RY, Koch KT, Baan J Jr, Vis MM, de Winter RJ, Piek JJ, Tijssen JG, Henriques JP; AIDA Investigators. Bioresorbable Scaffolds versus Metallic Stents in Routine PCI. N Engl J Med. 2017 Mar 29. [Epub ahead of print]. . Most of these events have consisted of scaffold thrombosis (ScT) and target vessel myocardial infarctions (MI) during the follow-up period. This risk has been attributed mainly to two factors: 1) Absorb is a first-generation BRS, with substantially thicker and wider struts than contemporary metallic DES; and 2) the lesion selection and scaffold implant technique employed in these early trials was suboptimal, with a high rate of Absorb use in vessels smaller than intended for the device (leading to excessive polymer load and vessel surface area coverage), and without routine high-pressure post-dilatation to ensure maximal scaffold expansion and apposition. Indeed, in several non-randomised studies optimal technique has been associated with low rates of adverse events after Absorb implantation55. Puricel S, Cuculi F, Weissner M, Schmermund A, Jamshidi P, Nyffenegger T, Binder H, Eggebrecht H, Münzel T, Cook S, Gori T. Bioresorbable Coronary Scaffold Thrombosis: Multicenter Comprehensive Analysis of Clinical Presentation, Mechanisms, and Predictors. J Am Coll Cardiol. 2016;67:921-31. ,66. Ortega-Paz L, Capodanno D, Gori T, Nef H, Latib A, Caramanno G, Di Mario C, Naber C, Lesiak M, Capranzano P, Wiebe J, Mehilli J, Araszkiewicz A, Pyxaras S, Mattesini A, Geraci S, Naganuma T, Colombo A, Münzel T, Sabaté M, Tamburino C, Brugaletta S. Predilation, sizing and post-dilation scoring in patients undergoing everolimus-eluting bioresorbable scaffold implantation for prediction of cardiac adverse events: development and internal validation of the PSP score. EuroIntervention. 2017;12:2110-7. ,77. Tanaka A, Latib A, Kawamoto H, Jabbour RJ, Sato K, Miyazaki T, Naganuma T, Mangieri A, Pagnesi M, Montalto C, Chieffo A, Carlino M, Montorfano M, Colombo A. Clinical outcomes of a real-world cohort following bioresorbable vascular scaffold implantation utilising an optimised implantation strategy. EuroIntervention. 2017;12:1730-7. .

Surprisingly, despite extensive investigation in patients receiving metallic DES, little is known about the optimal duration of dual antiplatelet therapy (DAPT) after BRS. In the ABSORB randomised trials, DAPT was required for six to 12 months, and was optional thereafter, although 58% of patients remained on DAPT at two years (Stone GW, unpublished data). A detailed study of the potential impact of prolonged DAPT from these studies has not been reported.

In the present issue of EuroIntervention, Felix and colleagues report an analysis of the impact of DAPT duration after BRS from a pooled study of registries from three Dutch centres88. Felix CM, Vlachojannis GJ, IJsselmuiden AJ, Fam JM, Smits PC, Lansink WJ, Diletti R, Zijlstra F, Regar ES, Boersma E, Onuma Y, van Geuns RJ. Potentially increased incidence of scaffold thrombosis in patients treated with Absorb BVS who terminated DAPT before 18 months. EuroIntervention. 2017;13:177-84. .

A total of 658 treated patients had at least six months of DAPT treatment without ScT in this period, and no use of oral anticoagulants. Patient outcomes were examined from this point until 18 months, with median DAPT duration of 367 days. Most patients had one non-complex lesion treated, with mean scaffold diameter and length 3.1±0.4 and 20.9±5.8 mm, respectively. Of note, intravascular imaging was used in 31.3% of cases, and post-dilatation was performed in only 56.7% (pressure unreported). Five cases of ScT occurred between six and 18 months (0.83/100 patient-years [95% CI: 0.34-1.98]). The incidence of ScT was 0.26/100 patient-years on-DAPT vs. 1.77/100 patient-years off-DAPT, a non-significant difference (p=0.12). However, four of the five ScT cases occurred after one year; none of these four patients was taking DAPT at the time of the event, and in three patients DAPT was discontinued between 10 and 35 days prior, suggesting a temporal relationship. ScT was significantly increased in the first month after DAPT discontinuation compared to the month before (p=0.01).

Should routine DAPT duration after BRS be prolonged to 18 months (or longer) based on these data? Certainly, the present study has limitations that leave several critical questions unanswered. First, this report is a post hoc analysis of registries not designed to address the DAPT duration issue. Some inaccuracies in the timing of DAPT discontinuation are no doubt present. Second, the number of patients and number of ScT events are modest, leading to wide CIs around the point estimates for the event rates on-DAPT and off-DAPT. Indeed, off-DAPT was not significantly associated with increased ScT risk, other than in the first month after DAPT discontinuation. Third, the reasons for DAPT discontinuation were not recorded and are unknown. DAPT “disruption” due to bleeding or non-compliance after metallic DES has been associated with metallic stent thrombosis, but not if DAPT discontinuation was physician-directed in otherwise stable patients99. Mehran R, Baber U, Steg PG, Ariti C, Weisz G, Witzenbichler B, Henry TD, Kini AS, Stuckey T, Cohen DJ, Berger PB, Iakovou I, Dangas G, Waksman R, Antoniucci D, Sartori S, Krucoff MW, Hermiller JB, Shawl F, Gibson CM, Chieffo A, Alu M, Moliterno DJ, Colombo A, Pocock S. Cessation of dual antiplatelet treatment and cardiac events after percutaneous coronary intervention (PARIS): 2 year results from a prospective observational study. Lancet. 2013;382:1714-22. . Thus, although the fact that the ScT risk was particularly increased within one month after DAPT discontinuation suggests that maintenance on DAPT was suppressing these thrombotic events (a phenomenon also seen with metallic DES)1010. Mauri L, Kereiakes DJ, Yeh RW, Driscoll-Shempp P, Cutlip DE, Steg PG, Normand SL, Braunwald E, Wiviott SD, Cohen DJ, Holmes DR Jr, Krucoff MW, Hermiller J, Dauerman HL, Simon DI, Kandzari DE, Garratt KN, Lee DP, Pow TK, Ver Lee P, Rinaldi MJ, Massaro JM; DAPT Study Investigators. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med. 2014;371:2155-66. , the same reasons that prompted DAPT stoppage (e.g., bleeding or trauma) may also have increased platelet reactivity leading to ScT. Fourth, the baseline patient and lesion characteristics in those with vs. those without ScT, and on-DAPT vs. off-DAPT were not reported, and no attempt at multivariable adjustment was made to correct for the inevitable imbalances that are almost certain to be present between these groups. Thus, while it is reassuring that the rate of ScT in patients on DAPT between six and 18 months was low (~0.3% per year), was this because of continuous DAPT usage or because patients who tolerate prolonged DAPT represent a low-risk stable cohort? In this regard, 60.3% of patients in the DAPT cohort presented with STEMI or NSTEMI, subgroups in whom at least 12 months of DAPT is indicated regardless of treatment1111. Levine GN, Bates ER, Bittl JA, Brindis RG, Fihn SD, Fleisher LA, Granger CB, Lange RA, Mack MJ, Mauri L, Mehran R, Mukherjee D, Newby LK, O’Gara PT, Sabatine MS, Smith PK, Smith SC Jr. 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2016;68:1082-115. , and in whom even more prolonged DAPT may be useful1212. Yeh RW, Kereiakes DJ, Steg PG, Windecker S, Rinaldi MJ, Gershlick AH, Cutlip DE, Cohen DJ, Tanguay JF, Jacobs A, Wiviott SD, Massaro JM, Iancu AC, Mauri L; DAPT Study Investigators. Benefits and Risks of Extended Duration Dual Antiplatelet Therapy After PCI in Patients With and Without Acute Myocardial Infarction. J Am Coll Cardiol. 2015;65:2211-21. . Did the very late ScT cases off-DAPT cluster in these patients? An apt question would be whether prolonged DAPT after BRS is necessary in stable patients, in whom DAPT for only six months has become the standard of care with metallic DES1111. Levine GN, Bates ER, Bittl JA, Brindis RG, Fihn SD, Fleisher LA, Granger CB, Lange RA, Mack MJ, Mauri L, Mehran R, Mukherjee D, Newby LK, O’Gara PT, Sabatine MS, Smith PK, Smith SC Jr. 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2016;68:1082-115. . Unfortunately, results are not provided according to presentation with acute coronary syndromes vs. stable ischaemic heart disease. Similarly, anatomic lesion complexity can affect the benefit-risk ratio of prolonged DAPT after metallic DES1313. Giustino G, Chieffo A, Palmerini T, Valgimigli M, Feres F, Abizaid A, Costa RA, Hong MK, Kim BK, Jang Y, Kim HS, Park KW, Gilard M, Morice MC, Sawaya F, Sardella G, Genereux P, Redfors B, Leon MB, Bhatt DL, Stone GW, Colombo A. Efficacy and Safety of Dual Antiplatelet Therapy After Complex PCI. J Am Coll Cardiol. 2016;68:1851-64. , and likely after BRS. Unfortunately, subgroup analysis based on lesion-related factors was not provided. We are also not informed whether an interaction was observed between technique-related factors and DAPT duration. It may be that prolonged DAPT is only beneficial in patients in whom vessel or device sizing is not optimal or in whom high-pressure post-dilatation is not performed, increasing the risk of acute malapposition with subsequent intraluminal scaffold dismantling (ILSD) during the bulk erosion process1414. Stone GW, Granada JF. Very Late Thrombosis After Bioresorbable Scaffolds: Cause for Concern? J Am Coll Cardiol. 2015;66:1915-7. . This worthy hypothesis requires validation in future studies. As a fifth limitation, the rates of bleeding in the two groups are not reported, the “dark side” of prolonged DAPT that may offset its beneficial effects1515. Palmerini T, Benedetto U, Bacchi-Reggiani L, Della Riva D, Biondi-Zoccai G, Feres F, Abizaid A, Hong MK, Kim BK, Jang Y, Kim HS, Park KW, Genereux P, Bhatt DL, Orlandi C, De Servi S, Petrou M, Rapezzi C, Stone GW. Mortality in patients treated with extended duration dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and Bayesian network meta-analysis of randomised trials. Lancet. 2015;385:2371-82. . Finally, the 18-month follow-up duration may not be long enough to characterise the risk period of Absorb bioresorption, which continues for ~3 years, at which time all polymer has been replaced by a provisional matrix.

Thus, while the authors are to be congratulated for the first publication to address whether prolonged DAPT reduces ischaemic complications after coronary BRS implantation, what are the practical implications? Prolonged DAPT clearly reduces thrombosis arising from coronary segments treated with metallic stents, as well as MI from untreated remote sites, and there is no reason to believe that these effects would be any less after BRS. Indeed, given novel failure modes of BRS (ILSD, and in rare cases late recoil), a strong case can be made for three years of DAPT (the time of complete Absorb bioresorption) in patients without excessive bleeding risk1616. Palmerini T, Stone GW. Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: conceptual evolution based on emerging evidence. Eur Heart J. 2016;37:353-64. . However, the evidence base for this recommendation is not as strong as I would like, and confirmation is required from larger, prospective studies in which the causes of DAPT discontinuation are tracked and outcomes are adjusted by confounding variables, including implantation technique. Finally, second-generation BRS are being introduced with markedly thinner struts and improved expansion and ease-of-use characteristics that promise to improve the intermediate-term benefit-risk profile of BRS, and which may alter the DAPT duration equation11. Kereiakes DJ, Onuma Y, Serruys PW, Stone GW. Bioresorbable Vascular Scaffolds for Coronary Revascularization. Circulation. 2016;134:168-82. . Given the rapid pace with which BRS technology is evolving, and the non-trivial risks of prolonged DAPT, vigilance and a willingness to adapt as new data emerge are required to ensure the best outcomes for our patients.

Conflict of interest statement

G. Stone is Chairman of the global Absorb clinical program (uncompensated) and a consultant to Reva.

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References

  • 1. Kereiakes DJ, Onuma Y, Serruys PW, Stone GW. Bioresorbable Vascular Scaffolds for Coronary Revascularization. Circulation. 2016;134:168-82.
  • 2. Stone GW, Gao R, Kimura T, Kereiakes DJ, Ellis SG, Onuma Y, Cheong WF, Jones-McMeans J, Su X, Zhang Z, Serruys PW. 1-year outcomes with the Absorb bioresorbable scaffold in patients with coronary artery disease: a patient-level, pooled meta-analysis. Lancet. 2016;387:1277-89.
  • 3. Sorrentino S, Giustino G, Mehran R, Kini AS, Sharma SK, Faggioni M, Farhan S, Vogel B, Indolfi C, Dangas GD. Everolimus-Eluting Bioresorbable Scaffolds versus Metallic Everolimus-Eluting Stents: Meta-Analysis of Randomized Controlled Trials. J Am Coll Cardiol. 2017 Apr 12. [Epub ahead of print]
  • 4. Wykrzykowska JJ, Kraak RP, Hofma SH, van der Schaaf RJ, Arkenbout EK, IJsselmuiden AJ, Elias J, van Dongen IM, Tijssen RY, Koch KT, Baan J Jr, Vis MM, de Winter RJ, Piek JJ, Tijssen JG, Henriques JP; AIDA Investigators. Bioresorbable Scaffolds versus Metallic Stents in Routine PCI. N Engl J Med. 2017 Mar 29. [Epub ahead of print].
  • 5. Puricel S, Cuculi F, Weissner M, Schmermund A, Jamshidi P, Nyffenegger T, Binder H, Eggebrecht H, Münzel T, Cook S, Gori T. Bioresorbable Coronary Scaffold Thrombosis: Multicenter Comprehensive Analysis of Clinical Presentation, Mechanisms, and Predictors. J Am Coll Cardiol. 2016;67:921-31.
  • 6. Ortega-Paz L, Capodanno D, Gori T, Nef H, Latib A, Caramanno G, Di Mario C, Naber C, Lesiak M, Capranzano P, Wiebe J, Mehilli J, Araszkiewicz A, Pyxaras S, Mattesini A, Geraci S, Naganuma T, Colombo A, Münzel T, Sabaté M, Tamburino C, Brugaletta S. Predilation, sizing and post-dilation scoring in patients undergoing everolimus-eluting bioresorbable scaffold implantation for prediction of cardiac adverse events: development and internal validation of the PSP score. EuroIntervention. 2017;12:2110-7.
  • 7. Tanaka A, Latib A, Kawamoto H, Jabbour RJ, Sato K, Miyazaki T, Naganuma T, Mangieri A, Pagnesi M, Montalto C, Chieffo A, Carlino M, Montorfano M, Colombo A. Clinical outcomes of a real-world cohort following bioresorbable vascular scaffold implantation utilising an optimised implantation strategy. EuroIntervention. 2017;12:1730-7.
  • 8. Felix CM, Vlachojannis GJ, IJsselmuiden AJ, Fam JM, Smits PC, Lansink WJ, Diletti R, Zijlstra F, Regar ES, Boersma E, Onuma Y, van Geuns RJ. Potentially increased incidence of scaffold thrombosis in patients treated with Absorb BVS who terminated DAPT before 18 months. EuroIntervention. 2017;13:177-84.
  • 9. Mehran R, Baber U, Steg PG, Ariti C, Weisz G, Witzenbichler B, Henry TD, Kini AS, Stuckey T, Cohen DJ, Berger PB, Iakovou I, Dangas G, Waksman R, Antoniucci D, Sartori S, Krucoff MW, Hermiller JB, Shawl F, Gibson CM, Chieffo A, Alu M, Moliterno DJ, Colombo A, Pocock S. Cessation of dual antiplatelet treatment and cardiac events after percutaneous coronary intervention (PARIS): 2 year results from a prospective observational study. Lancet. 2013;382:1714-22.
  • 10. Mauri L, Kereiakes DJ, Yeh RW, Driscoll-Shempp P, Cutlip DE, Steg PG, Normand SL, Braunwald E, Wiviott SD, Cohen DJ, Holmes DR Jr, Krucoff MW, Hermiller J, Dauerman HL, Simon DI, Kandzari DE, Garratt KN, Lee DP, Pow TK, Ver Lee P, Rinaldi MJ, Massaro JM; DAPT Study Investigators. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med. 2014;371:2155-66.
  • 11. Levine GN, Bates ER, Bittl JA, Brindis RG, Fihn SD, Fleisher LA, Granger CB, Lange RA, Mack MJ, Mauri L, Mehran R, Mukherjee D, Newby LK, O’Gara PT, Sabatine MS, Smith PK, Smith SC Jr. 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2016;68:1082-115.
  • 12. Yeh RW, Kereiakes DJ, Steg PG, Windecker S, Rinaldi MJ, Gershlick AH, Cutlip DE, Cohen DJ, Tanguay JF, Jacobs A, Wiviott SD, Massaro JM, Iancu AC, Mauri L; DAPT Study Investigators. Benefits and Risks of Extended Duration Dual Antiplatelet Therapy After PCI in Patients With and Without Acute Myocardial Infarction. J Am Coll Cardiol. 2015;65:2211-21.
  • 13. Giustino G, Chieffo A, Palmerini T, Valgimigli M, Feres F, Abizaid A, Costa RA, Hong MK, Kim BK, Jang Y, Kim HS, Park KW, Gilard M, Morice MC, Sawaya F, Sardella G, Genereux P, Redfors B, Leon MB, Bhatt DL, Stone GW, Colombo A. Efficacy and Safety of Dual Antiplatelet Therapy After Complex PCI. J Am Coll Cardiol. 2016;68:1851-64.
  • 14. Stone GW, Granada JF. Very Late Thrombosis After Bioresorbable Scaffolds: Cause for Concern? J Am Coll Cardiol. 2015;66:1915-7.
  • 15. Palmerini T, Benedetto U, Bacchi-Reggiani L, Della Riva D, Biondi-Zoccai G, Feres F, Abizaid A, Hong MK, Kim BK, Jang Y, Kim HS, Park KW, Genereux P, Bhatt DL, Orlandi C, De Servi S, Petrou M, Rapezzi C, Stone GW. Mortality in patients treated with extended duration dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and Bayesian network meta-analysis of randomised trials. Lancet. 2015;385:2371-82.
  • 16. Palmerini T, Stone GW. Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: conceptual evolution based on emerging evidence. Eur Heart J. 2016;37:353-64.