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Evidence-based medicine, transparency and reproducibility in research, and challenges for peer review


It seems that hardly a week goes by without an article appearing discussing the challenges facing biomedical research1,2. At the same time, the importance of clinical research and evidence-based medicine for decision making continues to grow2. In cardiology, in particular, many of the treatments that we recommend for our patients are supported by high-quality evidence showing favourable risk-benefit profiles against alternative or placebo treatments. Clinical practice guidelines have become an integral part of daily practice in cardiology, with committees regularly reviewing the totality of evidence in a given…

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