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Expert review

A systematic review and meta-analysis of surgical outcomes following mitral valve surgery in octogenarians: implications for transcatheter mitral valve interventions

1. Department of Medicine, Division of Cardiology, Interventional Cardiology, McGill University Health Centre, Montreal, Quebec, Canada; 2. Department of Epidemiology and Biostatistics, McGill University Health Centre, Montreal, Quebec, Canada; 3. Department of Cardiovascular Surgery, McGill University Health Centre, Montreal, Quebec, Canada; 4. Department of Cardiovascular Surgery, German Heart Center Munich, Munich, Germany

Abstract

Aims: To evaluate the outcomes of mitral valve surgery in octogenarians with severe symptomatic mitral regurgitation (MR).

Methods and results: We performed a systematic review and meta-analysis of data on octogenarians who underwent mitral valve replacement (MVR) or mitral valve repair (MVRpr). Our search yielded 16 retrospective studies. Using Bayesian hierarchical models, we estimated the pooled proportion of 30-day mortality, postoperative stroke, and long-term survival. The pooled proportion of 30-day postoperative mortality was 13% following MVR (10 studies, 3,105 patients, 95% credible interval [CI] 9-18%), and 7% following MVRpr (six studies, 2,642…

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