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INTERVENTIONS FOR STRUCTURAL HEART DISEASE

Percutaneous mitral valve repair with the MitraClip: early results from the MitraClip Asia-Pacific Registry (MARS)

1. Department of Cardiology, National Heart Centre Singapore, Singapore, Singapore; 2. Duke-NUS Graduate Medical School, Singapore, Singapore; 3. Department of Cardiology, Sir Charles Gairdner Hospital, Perth, Australia; 4. Department of Cardiology, Institut Jantung Negara, Kuala Lumpur, Malaysia; 5. Department of Cardiology, National University Heart Centre, Singapore; 6. Department of Cardiology, Prince Charles Hospital, Brisbane, Australia; 7. Medistra Hospital, Jakarta, Indonesia; 8. Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China; 9. Department of Cardiology, St Vincent’s Hospital, Sydney, Australia; 10. Department of Cardiothoracic Surgery, St Vincent’s Hospital, Sydney, Australia; 11. Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, Perth, Australia; 12. Department of Cardiology, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia

Aims: Percutaneous MitraClip therapy has been shown to be safe and efficacious in mitral regurgitation (MR). Our aim was to describe early outcomes in patients from the Asia-Pacific region.

Methods and results: The MitraClip Asia-Pacific Registry (MARS) includes data from eight different centres in five countries in the Asia-Pacific region. The primary efficacy outcome was reduction in MR to ≤2+ at 30 days. The safety outcome was 30-day freedom from major adverse events (MAE), defined as the composite of death, myocardial infarction, non-elective cardiac surgery, renal failure, transfusion of ≥2 units of blood, ventilation for >48 hours, septicaemia, and new onset atrial fibrillation. A total of 142 patients underwent the MitraClip procedure from February 2011 to October 2013. Fifty-three point five percent (76) of patients had functional MR, 45.8% (65) had degenerative MR and 0.7% (1) had mixed MR. The acute procedural success rate was 93.7% (133). Thirty-one point seven percent of the patients were in NYHA Class I-II at baseline, compared to 82.1% at 30 days (p<0.001). Zero percent (0) of the patients had ≤2+ MR at baseline compared to 76.8% (109) at 30 days (p<0.001).

Conclusions: Results from the Asia-Pacific region show that the MitraClip procedure is effective in reducing mitral regurgitation and has favourable short-term safety outcomes.

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