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A Novel Constrained, Paclitaxel coated Angioplasty Balloon Catheter

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1. Universitaetsklinikum des Saarlandes, Homburg/Saar,, GERMANY

Abstract

Objective: The study assessed drug adherence, transfer to the vessel wall, tolerance and efficacy of a constrained angioplasty balloon (Chocolate™) coated with an excipient enhanced paclitaxel coating (CCB) in the porcine model.

Methods: Drug adherence was investigated in vitro. Drug transfer was evaluated in porcine arteries. A stent overstretch model was chosen to provoke intimal thickening in the efficacy and tolerance study. Conventional uncoated balloons were used as controls. CCB were coated with a nominal (3µg/mm2) and high dose (2 completely overlapping…

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