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Just accepted article

Difference in hemodynamic microenvironment in vessels scaffolded with Absorb BVS and Mirage BRMS: Insights from a pre-clinical endothelial shear stress study

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1. Department of Interventional Cardiology, Erasmus University Medical Center, Thoraxcenter, Rotterdam, The Netherlands.; 2. Department of Mechanical Engineering, University College London, United Kingdom; 3. Department of Mechanical Engineering, University College London, United Kingdom. Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.; 4. Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; 5. Department of Interventional Cardiology, Erasmus University Medical Center, Thoraxcenter, Rotterdam, The Netherlands.; 6. Department of Interventional Cardiology, Erasmus University Medical Center, Thoraxcenter, Rotterdam, The Netherlands.; 7. Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; 8. Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; 9. Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.; 10. Department of Interventional Cardiology, Erasmus University Medical Center, Thoraxcenter, Rotterdam, The Netherlands.; 11. NETHERLANDS

Abstract

Background: In-silico studies have provided robust evidence that stent design affects local hemodynamic forces,which appear as a major determinant of clinical outcomes following stent implantation.However,implications of different stent/scaffold configurations on local hemodynamic forces have not yet been investigated in-vivo in a comparative fashion.

Method and Results: Eight healthy mini-pigs were implanted with six Absorb everolimus-eluting Bioresorbable Vascular Scaffolds (Absorb BVS) and five Mirage sirolimus-eluting Bioresorbable Microfiber Scaffolds (Mirage BRMS). Optical coherence tomography(OCT) was performed and strut protrusion was assessed post scaffold implantation.Following…

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