Nicole Karam
Latest contributions
Valvular interventions: are we entering the new age?
22 Sep 2025
Discover what D. Milasinovic and N. Karam shared on the practice of valvular interventions.
Focus on Fundamentals in TAVI and mitral - PCR London Valves 2024
Christopher Cook interviews Nicole Karam about the Fundamentals Course, a key component of the PCR London Valves programme that continues to expand each year. Designed for beginners in TAVI or mitral interventions, the course guides participants through every step of a procedure, starting with the basics...
Tricuspid transcatheter edge-to-edge repair - The fundamentals
25 Nov 2024 – From PCR London Valves 2024
Ready to dive into tricuspid transcatheter edge-to-edge repair (TEER)? This video breaks down the procedure by exploring real-world cases and key techniques.
Through practical case presentations, you'll gain insights into the anatomical criteria that determine suitability for TEER, the importance of imaging and haemodynamic assessments and the...
New technology for transcather valve replacement - LIVE case
25 Nov 2024 – From PCR London Valves 2024
Watch a series of recorded cases showcasing advanced valve therapies and innovative techniques:
- A 70-year-old man with Marfan syndrome (treated by Bentall and CABG in 2012), impaired LV function (35%), CRT-D, and symptomatic severe primary MR (A2 prolapse with calcification) underwent implantation of an Intrepid valve under...
Focus on PCR Innovators Day
18 Jun 2024 – From EuroPCR 2024
Nicole Karam and Nicolo Piazza highlighted EuroPCR 2024's PCR Innovators Day, which gathered over 400 physicians, ventures, industry partners, and investors to exchange ideas and network. Key topics included valve disease, heart failure, denervation, and the obstacles to innovation across different geographies, addressed in the innovator...
Edge-to-edge repair for primary mitral regurgitation: the good, the bad and the ugly
16 May 2024 – From EuroPCR 2024
Discover how to select suitable patients for TEER of primary mitral regurgitation, tackle anatomical challenges, understand the technique's limits, and gain insights into managing complexities and identifying cases where TEER may not be ideal.
Planning for a lifetime starts with choosing the right valve first: from first TAVI to redo-TAVI
15 May 2024 – From EuroPCR 2024
Watch this session to learn the best practices for treating aortic stenosis, with a focus on lifetime management. Gain insights into evaluating patient anatomy and clinical presentation to anticipate the need for a second valve, understand different valve designs and their initial selection, and observe a...
Innovations in heart failure: moving the heart forward
13 May 2024 – From EuroPCR 2024
Feedback from Innovator's Exchange Hub
13 May 2024 – From EuroPCR 2024
Feedback from Innovator's Exchange Hub
13 May 2024 – From EuroPCR 2024
Innovations in transcatheter valve interventions: moving the flow in the right direction
13 May 2024 – From EuroPCR 2024
How to identify patients for tricuspid interventions
14 Dec 2023
Watch the replay of this webinar with J. Hausleiter, P. Lüdike, M. Adamo, N. Karam and N. Wunderlich to know more about the clinical presentation and medical therapy of patients with tricuspid regurgitation and much more!
Is only fixing functional mitral regurgitation in heart failure patients enough?
20 Nov 2023 – From PCR London Valves 2023
This session offers insights into combo therapy involving Carillon for patients with functional mitral regurgitation. It covers details of the EMPOWER trial, a double-blinded, sham-controlled study, and explores the potential benefits of early treatment for patients with functional mitral regurgitation.
Challenges in TAVIs, are there guideline recommendations?
20 Nov 2023 – From PCR London Valves 2023
The EAPCI consensus session emphasized the critical role of evaluating and managing coronary artery disease in TAVI candidates, especially in younger and lower-risk patients. Transcatheter heart valve choice influences future coronary access, emphasizing the need for optimized implantation techniques. In cardiogenic shock due to valvular heart...
How to treat my patient with combined aortic and mitral valve disease
20 Nov 2023 – From PCR London Valves 2023
Explore this session to gain insights into diverse treatment options for combined heart valve disease. Examine the distinctions between surgical and transcatheter approaches, understanding their nuances, the sequential order of treatment and technical considerations crucial for transcatheter interventions.
Tricuspid valve intervention in complex scenarios - Tackling tricuspid regurgitation using a multidisciplinary approach
20 Nov 2023 – From PCR London Valves 2023
This session explores the diverse phenotypes of tricuspid regurgitation patients, emphasizing the clinical implications and advocating for a multidisciplinary approach to assessment and treatment. It covers TR clinical courses, investigation pathways, and case scenarios, including atrial fibrillation, heart failure (preserved and reduced ejection fraction), pulmonary hypertension,...
Key questions in tricuspid valve intervention - How do I define treatment options according to individual patient anatomy?
19 Nov 2023 – From PCR London Valves 2023
Explore this tricuspid valve-focused session featuring analysis of four clinical cases: Ebstein anomaly, severe and torrential tricuspid regurgitations, and anterior flail-related torrential regurgitation. Gain insights into optimal treatment selection for each scenario, leveraging pre-procedural imaging for informed decision-making.
Tricuspid Late-Breaking Trials: TRISCEND at 2 years, TEER in primary tricuspid regurgitation, TriCLASP, bRIGHT...
19 Nov 2023 – From PCR London Valves 2023
Discover the tricuspid late-breaking trials which were presented during PCR London Valves 2023:
- TRISCEND study two-year outcomes: transfemoral TTVR
- Transcatheter edge-to-edge repair in patients with primary tricuspid regurgitation
- One-year outcomes of transcatheter tricuspid valve repair from the TriCLASP study
- TTVR with the LuX-Valve system: one-year outcomes of a multicentre experience
- Real-world...
Key questions in tricuspid valve intervention - How does the role of the right heart and pulmonary vasculature influence patient selection?
19 Nov 2023 – From PCR London Valves 2023
Explore insights from an 86-year-old female patient's case with TAVR since end-2022 who presented with permanent AF, moderate MR and TR regurgitation, and learn more about right heart catheterisation for patient selection, CT and CMR in tricuspid interventions, criteria for atrial secondary TR, and more!
Implications of TRILUMINATE, a randomized clinical trial of transcatheter repair for tricuspid regurgitation
17 May 2023 – From EuroPCR 2023
Listen to Nicole Karam and Fabien Praz talk about the latest update from the TRILUMINATE study, the very first randomized trial conducted to determine how to improve the prognosis of tricuspid regurgitation.
To do so, the study aimed at comparing optimal medical treatment with interventions with edge-to-edge repair.
The content...
Emerging indications for TAVI
18 May 2023 – From EuroPCR 2023
Consult this session if you want to learn about emergent indications of transcatheter treatment of aortic valve disease, to appreciate current gaps in the evidence base and hear about upcoming clinical trials, and to highlight new technologies that will address these treatment gaps.
EuroPCR 2023 Hotlines/Late-Breaking Trials: mitral and tricuspid valves disease
17 May 2023 – From EuroPCR 2023
The presenters share their views on a range of essays and studies. Join them for an update on: Early experience with a d-shape, monoleaflet TMVR system; Outcomes of Mitral Valve-in-Valve, Mitral Valve-in-Ring and Valve-in-Mitral Annular; Calcification: prospective MITRAL; DRAGONFLY-DMR: transcatheter repair by DragonFly device in mitral...
Transcatheter tricuspid valve interventions
17 May 2023 – From EuroPCR 2023
Consult this session if you want to understand clinical scenarios associated with tricuspid regurgitation, to learn the state of the art in devices and indications to treat tricuspid regurgitation, and to deepen into the available evidence of outcomes of different therapies for tricuspid regurgitation.
Triluminate trial: how these data impact my practice
In this video, members of the PCR Tricuspid Focus Group Nicole Karam and Ralph Stephan von Bardeleben, discuss the results of the Triluminate trial with David Adams and Paul Sorajja. Together they comment on the take-home messages presented during the ACC.23/WCC scientific sessions and how this...
Triluminate trial: deep dive into the outcomes
In this video, members of the PCR Tricuspid Focus Group Nicole Karam and Ralph Stephan von Bardeleben talk with David Adams and Paul Sorajja about the first landmark trial in the field of tricuspid valve disease, Triluminate. Together they discuss the results presented during the ACC.23/WCC...
Challenging case in mitral valve intervention
19 Feb 2023 – From PCR Tokyo Valves 2023
Consult this session to discover challenging mitral valve cases. Learn to anticipate challenging anatomy, determine optimal timing for MitraClip, and witness changes in degenerative and functional mitral regurgitation procedures.
Transcatheter edge-to-edge repair for challenging situations
19 Feb 2023 – From PCR Tokyo Valves 2023
Explore various innovative repairs repairs: MitraClip for degenerative regurgitation, TEER bridge therapy, successful combined MitraClip and TriClip procedure, and simultaneous mitral repair with LAA closure.
Mitral valve implantation and other technology
19 Feb 2023 – From PCR Tokyo Valves 2023
This session offers insight into advanced mitral valve technologies. It covers details of transapical off-pump repair with synthetic chordae, India's success in transcatheter double valve-in-valve, TMVI in failing valves, and more.
Other cardiac interventions
19 Feb 2023 – From PCR Tokyo Valves 2023
Explore innovative approaches to cardiac interventions featured at PCR Tokyo Valves 2023: from performing TricValve implantation in Asian patients to addressing unique cases like transcatheter valve replacement with a novel tricuspid bioprosthesis. Discover how these experts navigated challenging scenarios!
Transcatheter repair for complex degenerative mitral regurgitation - LIVE case
18 Feb 2023 – From PCR Tokyo Valves 2023
An 83-year-old female with chronic kidney disease, RBBB, has severe mitral regurgitation due to P2 prolapse and preserved LV function (69 %).
The operators decide to implant 1 XTW clip, guided by TEE and left atrial pressure.
LIVE Case from Kokura Memorial Hospital Kitakyushu, Japan
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