Nicole Karam
Latest contributions
All about PCR’s Teaching Assessment Board (TAB)
03 Dec 2025
Learn how session feedback is compiled to create a virtuous cycle of continuous refinement for education in #interventionalcardiology
Tricuspid repair or replacement - Matching the patient to the procedural strategy
17 Nov 2025 – From PCR London Valves 2025
This session addresses the nuanced decision-making process in selecting appropriate transcatheter tricuspid repair or replacement strategies. It covers the current device landscape, patient selection criteria based on anatomical and clinical factors, and discusses emerging challenges such as pacing lead management, anticoagulation, and outcome definitions.
Early Career Research Award Final
17 Nov 2025 – From PCR London Valves 2025
Highlighting pioneering research in structural heart interventions, this session presents studies on the impact of transcatheter tricuspid valve replacement (TTVR) on left ventricular geometry and function, myocardial remodeling in aortic stenosis, physiological responses after mitral and tricuspid edge-to-edge repairs, advancing the understanding of device effects on...
Mitral TEER - LIVE Case
16 Nov 2025 – From PCR London Valves 2025
Watch this live case followed by a recorded case, regarding a 75-year-old male with type 2 DM, permanent AF, and severe LV dysfunction (30%), with a history of RCA PCI one month earlier and three hospitalizations for heart failure, presented with severe secondary mitral and tricuspid...
Mitral regurgitation: from guidelines to clinical practice
16 Nov 2025 – From PCR London Valves 2025
This LIVE case symposium brings mitral regurgitation guidelines into real clinical practice. Through step-by-step patient demonstrations and insightful discussion, the session explores how recommendations guide decision-making in ventricular and atrial secondary MR, how the heart team tailors therapy to individual anatomy and comorbidities, and how device iterations...
Valvular interventions: are we entering the new age?
22 Sep 2025
Discover what D. Milasinovic and N. Karam shared on the practice of valvular interventions.
Innovation to address unmet clinical needs in transcatheter valve therapies
22 May 2025 – From EuroPCR 2025
Discover innovations addressing unmet clinical needs in transcatheter valve therapies. This session shares case-based experiences including young aortic stenosis patients, mitral regurgitation with annular calcification, and severe tricuspid regurgitation with right ventricular dysfunction, alongside the latest advances in TAVI, TMVR, and tricuspid interventions.
How to build a tricuspid programme?
20 May 2025 – From EuroPCR 2025
Learn how to build a successful tricuspid valve programme with a focus on patient screening protocols, heart team roles, and post-procedural management. Gain expert perspectives on organizational requirements, referral optimization, multidisciplinary collaboration, and quality assessment for tricuspid interventions.
How to deal with secondary mitral regurgitation in 2025?
20 May 2025 – From EuroPCR 2025
Delve into the evolving management of secondary mitral regurgitation, and the critical role of the Heart Team. This session replay presents the latest clinical trials, treatment guidelines, and a case-based discussion covering medical and interventional strategies, heart failure optimization, frailty assessment, and advanced imaging techniques.
What is new in atrioventricular valves?
19 May 2025 – From EuroPCR 2025
Discover the latest advancements in atrioventricular valve interventions, including innovative transcatheter repair technologies and first-in-human experiences with novel devices.
Focus on Fundamentals in TAVI and mitral - PCR London Valves 2024
Christopher Cook interviews Nicole Karam about the Fundamentals Course, a key component of the PCR London Valves programme that continues to expand each year. Designed for beginners in TAVI or mitral interventions, the course guides participants through every step of a procedure, starting with the basics...
New technology for transcather valve replacement - LIVE case
25 Nov 2024 – From PCR London Valves 2024
Watch a series of recorded cases showcasing advanced valve therapies and innovative techniques:
- A 70-year-old man with Marfan syndrome (treated by Bentall and CABG in 2012), impaired LV function (35%), CRT-D, and symptomatic severe primary MR (A2 prolapse with calcification) underwent implantation of an Intrepid valve under...
Tricuspid transcatheter edge-to-edge repair - The fundamentals
25 Nov 2024 – From PCR London Valves 2024
Ready to dive into tricuspid transcatheter edge-to-edge repair (TEER)? This video breaks down the procedure by exploring real-world cases and key techniques.
Through practical case presentations, you'll gain insights into the anatomical criteria that determine suitability for TEER, the importance of imaging and haemodynamic assessments and the...
Focus on PCR Innovators Day
18 Jun 2024 – From EuroPCR 2024
Nicole Karam and Nicolo Piazza highlighted EuroPCR 2024's PCR Innovators Day, which gathered over 400 physicians, ventures, industry partners, and investors to exchange ideas and network. Key topics included valve disease, heart failure, denervation, and the obstacles to innovation across different geographies, addressed in the innovator...
Edge-to-edge repair for primary mitral regurgitation: the good, the bad and the ugly
16 May 2024 – From EuroPCR 2024
Discover how to select suitable patients for TEER of primary mitral regurgitation, tackle anatomical challenges, understand the technique's limits, and gain insights into managing complexities and identifying cases where TEER may not be ideal.
Planning for a lifetime starts with choosing the right valve first: from first TAVI to redo-TAVI
15 May 2024 – From EuroPCR 2024
Watch this session to learn the best practices for treating aortic stenosis, with a focus on lifetime management. Gain insights into evaluating patient anatomy and clinical presentation to anticipate the need for a second valve, understand different valve designs and their initial selection, and observe a...
Feedback from Innovator's Exchange Hub
13 May 2024 – From EuroPCR 2024
Innovations in heart failure: moving the heart forward
13 May 2024 – From EuroPCR 2024
Feedback from Innovator's Exchange Hub
13 May 2024 – From EuroPCR 2024
Innovations in transcatheter valve interventions: moving the flow in the right direction
13 May 2024 – From EuroPCR 2024
How to identify patients for tricuspid interventions
14 Dec 2023
Watch the replay of this webinar with J. Hausleiter, P. Lüdike, M. Adamo, N. Karam and N. Wunderlich to know more about the clinical presentation and medical therapy of patients with tricuspid regurgitation and much more!
Challenges in TAVIs, are there guideline recommendations?
20 Nov 2023 – From PCR London Valves 2023
The EAPCI consensus session emphasized the critical role of evaluating and managing coronary artery disease in TAVI candidates, especially in younger and lower-risk patients. Transcatheter heart valve choice influences future coronary access, emphasizing the need for optimized implantation techniques. In cardiogenic shock due to valvular heart...
Tricuspid valve intervention in complex scenarios - Tackling tricuspid regurgitation using a multidisciplinary approach
20 Nov 2023 – From PCR London Valves 2023
This session explores the diverse phenotypes of tricuspid regurgitation patients, emphasizing the clinical implications and advocating for a multidisciplinary approach to assessment and treatment. It covers TR clinical courses, investigation pathways, and case scenarios, including atrial fibrillation, heart failure (preserved and reduced ejection fraction), pulmonary hypertension,...
How to treat my patient with combined aortic and mitral valve disease
20 Nov 2023 – From PCR London Valves 2023
Explore this session to gain insights into diverse treatment options for combined heart valve disease. Examine the distinctions between surgical and transcatheter approaches, understanding their nuances, the sequential order of treatment and technical considerations crucial for transcatheter interventions.
Is only fixing functional mitral regurgitation in heart failure patients enough?
20 Nov 2023 – From PCR London Valves 2023
This session offers insights into combo therapy involving Carillon for patients with functional mitral regurgitation. It covers details of the EMPOWER trial, a double-blinded, sham-controlled study, and explores the potential benefits of early treatment for patients with functional mitral regurgitation.
Key questions in tricuspid valve intervention - How do I define treatment options according to individual patient anatomy?
19 Nov 2023 – From PCR London Valves 2023
Explore this tricuspid valve-focused session featuring analysis of four clinical cases: Ebstein anomaly, severe and torrential tricuspid regurgitations, and anterior flail-related torrential regurgitation. Gain insights into optimal treatment selection for each scenario, leveraging pre-procedural imaging for informed decision-making.
Tricuspid Late-Breaking Trials: TRISCEND at 2 years, TEER in primary tricuspid regurgitation, TriCLASP, bRIGHT...
19 Nov 2023 – From PCR London Valves 2023
Discover the tricuspid late-breaking trials which were presented during PCR London Valves 2023:
- TRISCEND study two-year outcomes: transfemoral TTVR
- Transcatheter edge-to-edge repair in patients with primary tricuspid regurgitation
- One-year outcomes of transcatheter tricuspid valve repair from the TriCLASP study
- TTVR with the LuX-Valve system: one-year outcomes of a multicentre experience
- Real-world...
Key questions in tricuspid valve intervention - How does the role of the right heart and pulmonary vasculature influence patient selection?
19 Nov 2023 – From PCR London Valves 2023
Explore insights from an 86-year-old female patient's case with TAVR since end-2022 who presented with permanent AF, moderate MR and TR regurgitation, and learn more about right heart catheterisation for patient selection, CT and CMR in tricuspid interventions, criteria for atrial secondary TR, and more!
Implications of TRILUMINATE, a randomized clinical trial of transcatheter repair for tricuspid regurgitation
17 May 2023 – From EuroPCR 2023
Listen to Nicole Karam and Fabien Praz talk about the latest update from the TRILUMINATE study, the very first randomized trial conducted to determine how to improve the prognosis of tricuspid regurgitation.
To do so, the study aimed at comparing optimal medical treatment with interventions with edge-to-edge repair.
The content...
Emerging indications for TAVI
18 May 2023 – From EuroPCR 2023
Consult this session if you want to learn about emergent indications of transcatheter treatment of aortic valve disease, to appreciate current gaps in the evidence base and hear about upcoming clinical trials, and to highlight new technologies that will address these treatment gaps.
