What's new in Interventional Cardiology

Long-term evidence comparing PCI and CABG for unprotected left main coronary disease has been limited and sometimes conflicting. The 10-year results from the NOBLE trial now provide important clarity on all-cause mortality outcomes with both revascularisation strategies.

The RENOVATE-COMPLEX-PCI 5-year outcomes confirm the long-term durability of benefits seen with intracoronary imaging over angiography guided PCI in complex lesions.

A 68-year-old woman presents with symptomatic aortic stenosis and tricuspid valve anatomy, with no significant comorbidities and no evidence of coronary artery disease. Given her strong preference for a less invasive strategy, the Heart Team considers a transcatheter approach.
How would you treat this patient—and in case...

Jonathan Curio provides his take on TRISCEND II trial results presented by Vinod H. Thourani at ACC.26 in New Orleans.

Women have long been underrepresented in TAVR trials. This article explores the DEDICATE trial’s sex-specific outcomes after TAVI and SAVR, revealing differences in early stroke risk, procedural challenges, and one-year survival in men and women with aortic stenosis.

Mirvat Al Asnag provides her take on the ALL-RISE randomised trial presented by Ajay J. Kirtane at ACC.26 in New Orleans.

During the first Late-Breaking Trial session of the 2026 ACC Congress held in New Orleans, Saibal Kar, principal investigator of the CHAMPION-AF trial, presented the 3-year results of this groundbreaking study, which were simultaneously published in the NEJM (DOI: 10.1056/NEJMoa2517213).

Discriminating between coronary calcification and thrombus in acute settings remains a diagnostic challenge with significant implications for interventional decision-making.

An 85-year-old man presented in cardiogenic shock with torrential aortic regurgitation after prior surgical and TAVI valve-in-valve procedures. With high coronary obstruction risk, urgent CT assessment and in-silico simulations guided a rapid redo TAVI-in-TAVI-in-valve implantation, demonstrating that CT-assisted emergency redo-TAVI is feasible and lifesaving in high-risk...

Ali Nazmi Calik provides his take on the results of the OPTIMAL trial presented by Luca Testa at ACC.26 in New Orleans.