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Left main and multivessel disease

Find all the latest content on left main and multivessel disease published on this website.

The left main coronary artery provides the primary source of blood flow to the left ventricle. Diseases affecting the left main, by itself or in combination with multivessel disease, place the patient at significant risk for life-threatening cardiovascular events. Treatment requires an understanding of all available tools, devices and techniques, like those employed in invasive imaging and functional assessment, as well as taking into account underlying comorbidities such as diabetes. Advances in imaging techniques, as well as the use of adjunctive pharmacotherapy, vascular access or invasive interventions such as bypass surgery, are important, as are understanding bleeding risks. Use the filters below to access PCRonline resources.

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Left main and multivessel disease

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One price, unlimited learning: Holiday PCR Publishing offer

18 Dec 2025

Celebrate the season with our exclusive Christmas offer! Choose any digital subscription - EuroIntervention and/or The PCR Textbook – for €85.

Holiday Special: Any digital subscription for just €85 from 18 to 22 December only!

Left main - LIVE Case

10 Dec 2025 – From GulfPCR-GIM 2025

This session delivers an in-depth exploration of left main coronary artery intervention, featuring a live educational case from the Mohammed Bin Khalifa Bin Salman Al Khalifa Specialist Cardiac Centre in Awali, Bahrain. Attendees gain insights into the pivotal role of computed tomography and intravascular imaging in...

Left main - LIVE Case

Ten trials from AHA 2025

12 Nov 2025

Alessandro Sticchi provides us with a curated overview of the late-breaking trials he found most relevant for interventional cardiologists from AHA 2025.

Alessandro Sticchi

Author

Alessandro Sticchi
Ten trials from AHA 2025

Provisional stenting with a scaffold stent and DCB in calcified left main bifucation - LIVE Case

11 Oct 2025 – From AICT-AsiaPCR 2025

A 59-year-old male presented with CCS for three months, with diabetes and normal LV function (72%). Coronary angiography showed a calcified left main stenosis (Medina 1,1,1) and diffuse calcification of the proximal and mid LAD. The LCX QFR was 0.86.

Treatment included extensive lesion preparation with lithotripsy...

Provisional stenting with a scaffold stent and DCB in calcified left main bifucation - LIVE Case

Left main PCI - LIVE Case

10 Oct 2025 – From AICT-AsiaPCR 2025

A 78-year-old male with a history of LAD PCI in 1997 presented with an NSTEMI three months earlier due to diffuse three-vessel calcified disease, including: distal LM stenosis, severe mid and distal disease of a dominant RCA, and LAD in-stent restenosis. LV function was normal. He...

Left main PCI - LIVE Case

Large thrombus burden management in a young patient with inferior STEMI and multivessel disease

08 Oct 2025

A 51-year-old man with an inferior STEMI and multivessel disease was found to have a thrombotic sub-occlusion in the mid RCA. Angiography also revealed significant disease in the LAD. How would you manage this case?

Antonio Landi

Author

Antonio Landi
Andrea Milzi

Author

Andrea Milzi
Marco Valgimigli

Author

Marco Valgimigli
Large thrombus burden management in a young patient with inferior STEMI and multivessel disease

OPTION-STEMI: Immediate versus staged complete revascularisation during index admission in patients with STEMI and multivessel disease

02 Sep 2025

Mirvat Alasnag provides her take on OPTION-STEMI, presented by Youngkeun Ahn at ESC Congress 2025 in Madrid.

Dr. Mirvat Alasnag

Author

Mirvat Alasnag
OPTION STEMI - Immediate vs staged complete revascularisation during index admission in patients with STEMI & MVD

Hostile left main calcific stenosis in HFrEF

20 Aug 2025

Analyse this case to find out how to successfully manage a patient with a severely calcific left main stenosis and severely reduced ejection fraction.

Emanuele Gallinoro

Author

Emanuele Gallinoro
Riccardo Terzi

Author

Riccardo Terzi

Author

Francesca Di Lenarda
Hostile left main calcific stenosis in HFrEF

When high calcium burden meets a 75 year-old patient with previous CABG + SAVR + MVr

02 Jul 2025

This case illustrates how a fragile patient with severe three-vessel disease involving LM/LAD was treated. Watch now to find out more, and share your thoughts!

Filippo Pensotti

Author

Filippo Pensotti
Luca Testa

Author

Luca Testa
When high calcium burden meets a 75 year-old patient with previous CABG + SAVR + MVr: an intricate PCI stands as the last line of defense

Left main coronary artery disease

18 Jun 2025

This PCR Textbook outstanding chapter written by F.J. Neumann and colleagues reviews the management of left main coronary disease, comparing PCI and CABG, emphasising patient-specific factors, heart team input, and PCI techniques including imaging and antithrombotic therapy. Available exclusively to subscribers.

Authors :

Rodrigo Modolo, Norihiro Kogame, Hidenori Komiyama, Vasim Farooq, Gregg Stone, Renu Virmani, Patrick W. Serruys