S. Von Bardeleben

Ralph Stephan von Bardeleben

Interventional cardiologist / Cardiologist
Universitätsmedizin der Johannes Gutenberg-Universität Mainz - Mainz, Germany

Latest contributions

Tricuspid TEER: learnings from the 2-year outcomes of TRILUMINATE Pivotal trial & bRIGHT study

20 May 2025 – From EuroPCR 2025

At EuroPCR 2025, Marianna Adamo and Ralph Stephan von Bardeleben discussed the latest findings on tricuspid valve repair using transcatheter edge-to-edge repair (TEER).

The 2-year results from the TRILUMINATE Pivotal trial showed a significant reduction in tricuspid regurgitation, lasting improvements in quality of life, and a notable...

Tricuspid TEER: learnings from the 2-year outcomes of TRILUMINATE Pivotal trial & bRIGHT study

Tricuspid hotline: new devices

22 May 2025 – From EuroPCR 2025

Discover cutting-edge developments in transcatheter tricuspid valve replacement with new device technologies. Review first-in-human trials, early outcomes from multicenter studies, and innovative designs that promise to advance tricuspid regurgitation treatment.

Tricuspid hotline: new devices

Innovations in TMVR and Intrepid trial updates

21 May 2025 – From EuroPCR 2025

This EuroPCR 2025 session highlights the evolving role of transcatheter mitral valve replacement, focusing on the clinical potential of mitral regurgitation elimination. Get an overview of the current status of the Intrepid TMVR programme, learn about the transition to the 29Fr transfemoral system, and explore how...

Innovations in TMVR and Intrepid trial updates

Therapeutic choices for TTVIV-TTVIR interventions

21 May 2025 – From EuroPCR 2025

Explore therapeutic choices for transcatheter tricuspid valve-in-valve and valve-in-ring interventions. Case studies cover annular ring expansion, pacing-related infection, jugular vein access valve replacement, Ebstein anomaly, and double valve-in-valve procedures in right heart disease.

Therapeutic choices for TTVIV-TTVIR interventions

How to build a tricuspid programme?

20 May 2025 – From EuroPCR 2025

Learn how to build a successful tricuspid valve programme with a focus on patient screening protocols, heart team roles, and post-procedural management. Gain expert perspectives on organizational requirements, referral optimization, multidisciplinary collaboration, and quality assessment for tricuspid interventions.

How to build a tricuspid programme?

RESHAPING the transcatheter treatment of mitral and tricuspid regurgitation

25 Nov 2024 – From PCR London Valves 2024

Join this compelling session focused on the transcatheter treatment of mitral and tricuspid regurgitation. Explore detailed case discussions, including a mitral regurgitation case, a challenging MitraClip procedure, and a severe tricuspid regurgitation case. Discover key takeaways from the RESHAPE, MATTERHORN, and Tri.FR trials, and learn how...

RESHAPING the transcatheter treatment of mitral and tricuspid regurgitation

Mastering structural heart intervention with innovations in imaging

25 Nov 2024 – From PCR London Valves 2024

Explore the future of transcatheter mitral and tricuspid therapies in this innovative session. Learn how advanced imaging techniques like CT/fluoro fusion and 4D intracardiac echocardiography are revolutionizing complex procedures, enhancing both safety and outcomes. Hear from experienced operators as they share their insights on the evolving...

Mastering structural heart intervention with innovations in imaging

Multivalvular disease: diagnostic challenges and treatment strategies for aortic and mitral valve disorders

03 Feb 2024 – From PCR Imaging Valves Madrid 2024

Addressing the complex diagnostic challenges in aortic stenosis and regurgitation, this session examines the timing of treatment initiation and the decision-making process when aortic valve disease coincides with aortic pathology. It also explores the ongoing healthcare burden posed by mitral regurgitation and stenosis, emphasizing the importance...

Multivalvular disease: diagnostic challenges and treatment strategies for aortic and mitral valve disorders

TAVI essentials: anatomical factors, prosthesis selection, and complication management

02 Feb 2024 – From PCR Imaging Valves Madrid 2024

Discover a comprehensive exploration of critical considerations in TAVI in this section. From anatomical factors guiding the choice between TAVI and SAVR to strategies for selecting the optimal TAVI prosthesis for individual patients, each topic offers essential insights. Gain valuable insights into navigating TAVI for bicuspid...

TAVI essentials: anatomical factors, prosthesis selection, and complication management

Intracardiac echocardiography for tricuspid interventions

01 Dec 2023

Watch the replay of this webinar with R. Hahn, M. I. Koerber, S. Lim, F. Praz and R. S. Von Bardeleben to learn about the latest innovation for imaging the tricuspid valve and much more.

An intrepid solution for transfemoral treatment of mitral regurgitation

21 Nov 2023 – From PCR London Valves 2023

In this session, get insights into the APOLLO EU trial and its current progress, obtain a comprehensive understanding of the latest data from the Early Feasibility TF trial, and discern which patients stand to benefit the most from this treatment.

An intrepid solution for transfemoral treatment of mitral regurgitation

Complex tricuspid interventions

20 Nov 2023 – From PCR London Valves 2023

Consult this session to discover a selection of abstracts regarding tricuspid valve procedures: explore the complexities of long-term right heart remodeling after transcatheter tricuspid annuloplasty, witness the journey from pre-clinical studies to the first-in-man experience with MonarQ tricuspid valve replacement, delve into Tripair, an innovative transcatheter spacer...

Complex tricuspid interventions

Is only fixing functional mitral regurgitation in heart failure patients enough?

20 Nov 2023 – From PCR London Valves 2023

This session offers insights into combo therapy involving Carillon for patients with functional mitral regurgitation. It covers details of the EMPOWER trial, a double-blinded, sham-controlled study, and explores the potential benefits of early treatment for patients with functional mitral regurgitation.

Is only fixing functional mitral regurgitation in heart failure patients enough?

Advancing valve repair: mastering diverse mitral and tricuspid regurgitation anatomies with the PASCAL Precision system

20 Nov 2023 – From PCR London Valves 2023

Participate in this session to stay informed about the latest clinical and real-world evidence for mitral and tricuspid TEER using PASCAL. Explore case-based discussions on mitral regurgitation treatment using PASCAL Precision, and actively participate in an educational tricuspid TEER recorded case procedure featuring the PASCAL Precision.

Advancing valve repair: mastering diverse mitral and tricuspid regurgitation anatomies with the PASCAL Precision system

Expert roundtable: 4D ICE in tricuspid interventions

20 Nov 2023 – From PCR London Valves 2023

Join this session if you want to get familiar with the 4D ICE technology and the key elements of image guidance for tricuspid interventions, understand how 4D ICE can assist in specific procedural steps during challenging tricuspid interventions, and engage in an interactive discussion with experts...

Expert roundtable: 4D ICE in tricuspid interventions

Mitral Late-Breaking Trials: CLASP IID, AltaValve transseptal programme, MitraSwiss in men and women, MiCLASP...

19 Nov 2023 – From PCR London Valves 2023

Discover the mitral late-breaking trials which were presented during PCR London Valves 2023: 

  • One-year outcomes of transcatheter mitral repair from the CLASP IID Registry
  • AltaValve transseptal programme update
  • Mitral TEER in men and women from MitraSwiss registry: is equality achieved?
  • Combined impact of mitral valve gradients and mitral regurgitation reduction...
Mitral Late-Breaking Trials - PCR London Valves 2023

PCR Tricuspid Focus Group - referral meeting in Mainz

10 Jul 2023

Join your peers for this meeting on 7 September 2024 in Mainz, Germany!

Knocking mitral regurgitation down to improve outcomes: earlier is better, but better late than never! (Episode 2: the left side)

18 May 2023 – From EuroPCR 2023

Help optimize your patients' prognosis by attending this session! You'll learn how proper patient selection and timely interventions lead to lasting results and how to use the latest real-world registry data to gain insight into the safety and effectiveness of M TEER.

Innovations in TMVR and Intrepid trial updates

18 May 2023 – From EuroPCR 2023

This session explores the innovations in Transcatheter Mitral Valve replacement, with a special focus on the updates from the INTREPID and APOLLO EU trial, as well as patient benefits through case studies.

EuroPCR 2023 Hotlines/Late-Breaking Trials: mitral and tricuspid valves disease

17 May 2023 – From EuroPCR 2023

The presenters share their views on a range of essays and studies. Join them for an update on: Early experience with a d-shape, monoleaflet TMVR system; Outcomes of Mitral Valve-in-Valve, Mitral Valve-in-Ring and Valve-in-Mitral Annular; Calcification: prospective MITRAL; DRAGONFLY-DMR: transcatheter repair by DragonFly device in mitral...

Long-term valve performance for the next decade and beyond

17 May 2023 – From EuroPCR 2023

How can TAVI outcomes be made better for younger patients with longer life horizons? Check-out in this session where you also will be able to gain in the understanding of the structural challenges of providing TAVI services and see how innovation can contribute to optimal outcomes and...

Use of 4D ICE in tricuspid and mitral valve interventions

16 May 2023 – From EuroPCR 2023

Watch this session to know the challenges of TV imaging, to get an overview on 4D ICE technology, and to study both a transcatheter tricuspid valve procedure and a transcatheter mitral valve procedure through different case presentations, that will then be discussed.

Triluminate trial: how these data impact my practice

In this video, members of the PCR Tricuspid Focus Group Nicole Karam and Ralph Stephan von Bardeleben, discuss the results of the Triluminate trial with David Adams and Paul Sorajja. Together they comment on the take-home messages presented during the ACC.23/WCC scientific sessions and how this...

Triluminate trial: how these data impact my practice

Triluminate trial: deep dive into the outcomes

In this video, members of the PCR Tricuspid Focus Group Nicole Karam and Ralph Stephan von Bardeleben talk with David Adams and Paul Sorajja about the first landmark trial in the field of tricuspid valve disease, Triluminate. Together they discuss the results presented during the ACC.23/WCC...

Triluminate trial: deep dive into the outcomes

Multiple VHD: a diagnostic and clinical challenge

11 Mar 2023 – From PCR Imaging Valves Madrid 2023

Consult these presentations on multiple VHD to learn how to deal with combined valvular lesions, how to assess their severity and how to treat them.

Multiple VHD: a diagnostic and clinical challenge

Diagnosis and classification of tricuspid regurgitation

11 Mar 2023 – From PCR Imaging Valves Madrid 2023

Watch this session to learn more about the anatomy of the tricuspid valve and its challenges, to know when and how to treat tricuspid regurgitation, and to discover all about the latest classification regarding this condition.

Diagnosis and classification of tricuspid regurgitation

Tricuspid valve intervention - Get it right!

29 Nov 2022 – From PCR London Valves 2022

Watch this session if you want to learn tips and tricks that influence procedural strategy through a real-life case as well as anatomical factors that contribute to tricuspid valve complexity and choice of treatment, followed by the latest clinical data.

Surgical and transcatheter tricuspid intervention: state of the art - LIVE case

29 Nov 2022 – From PCR London Valves 2022

In this PCR London Valves 2022 session, follow 3 stunning case treatments:

  • Part 1: Triscupid TEER (Live)
    A 78-year-old male with a history of CABG (2015), PM-CRT (2015) and atrial fibrillation, presents a severe TR with an LVEF of 40%, preserved RV function and moderate pulmonary hypertension.
    They performed...
Surgical and transcatheter tricuspid intervention: state of the art

Innovations in TMVR and Intrepid trial updates

29 Nov 2022 – From PCR London Valves 2022

Watch this session if you want to gain insights on the APOLLO TMVR trial, the Intrepid trial and to hear about future innovations in mitral replacement.

Innovations in transcatheter tricuspid valve intervention - LIVE case

28 Nov 2022 – From PCR London Valves 2022

Watch two very innovative tricuspid cases you've never seen before:

  • Part 1: TR replacement
    An 82-year-old male with chronic atrial fibrillation and completely PM dependent for 27 years, presents a symptomatic torrential TR and an enlarged annulus with a great gap. The operators implanted for the first time in...
Innovations in transcatheter tricuspid valve intervention