MitraClip: Discover late breaking data and novel insights on mitral valve repair

Clinical outcomes with MitraClip (NTR/XTR): core-lab echo results

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Results:

• The availability of multiple Clip sizes enables physicians to achieve improved clinical outcomes when compared to previous studies that included 1 Clip size
  • Highest reported to date MR reduction at 30 days 87.1% MR ≤1+ in primary MR and 90.1% MR secondary MR
• Significant improvements in quality of life and functional capacity
• Early evidence of reduction in LV annular dimensions and volumes

Clip selection strategy and outcomes with MitraClip (NTR/XTR)

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Results:

The availability of multiple Clip sizes enables tailoring the therapy to patients individual MV anatomy:

• For Primary MR, MitraClip XTR achieved more favorable MR reduction in patients with more severe baseline MR, smaller annular dimensions, large prolapse gaps and complex MV anatomy
• For secondary MR, results show no evidence on advantage of Clip selection strategy over outcomes

Safety and effectiveness outcomes with MitraClip XTR system

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Results:

• The EXPAND study confirms the safety and performance of the next generation MitraClip XTR system in a contemporary real-world setting
• Adjudicated safety results with the XTR clip were similar to those with NTR clip

Mitral valve leaflet adverse events with MitraClip

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Results:

• The first comprehensive review of mitral valve leaflet adverse events (LAE) associated with MitraClip NTR/XTR by a panel of independent multi-disciplinary experts
• Adjudication results indicate low incidence of LAE in a multicenter, international study in real world settings