What's new in Interventional Cardiology

Catheter-based left atrial appendage closure (LAAC) is widely used as an alternative to oral anticoagulation in atrial fibrillation. But how does it compare with best medical therapy in patients at high risk of both stroke and bleeding? The CLOSURE-AF trial provides new data to inform this...

The ROLLING STONE registry compares intravascular lithotripsy (IVL) and atherectomy (rotational and orbital) for treating heavily calcified coronary arteries, assessing real-world safety and effectiveness in percutaneous coronary interventions (PCI).

This study provides the longest available follow-up for first-generation bioresorbable vascular scaffolds and fails to demonstrate any late clinical advantage after complete scaffold resorption.

The 3-year follow-up of the REC-CAGEFREE I trial demonstrated that a DCB-based strategy with rescue stenting was associated with a significantly higher rate of DOCE compared with contemporary DES implantation in patients with de novo, non-complex coronary artery disease.

The TICO1 and T-PASS2 trials evaluated abbreviated DAPT followed by ticagrelor monotherapy compared to DAPT in patients with ACS undergoing PCI. Both trials demonstrated the safety and efficacy of abbreviated DAPT however, the optimal timing of aspirin discontinuation remains uncertain. This post hoc analysis compares the...

A 79-year-old patient previously treated with surgical aortic valve replacement was referred after an episode of acute cardiac decompensation. Although clinically stabilised, further evaluation revealed degeneration of the bioprosthesis, and mixed aortic valve pathology.

This case focuses on the diagnostic assessment and the strategic considerations guiding the...

A 71-year-old low-risk patient with symptomatic severe aortic stenosis and preserved ventricular function presents with progressive dyspnoea and chest pain. With long life expectancy, the choice of treatment demands careful interdisciplinary planning. How would you treat?

A frail patient presents with worsening NYHA class III dyspnoea and peripheral oedema despite optimal medical therapy. Previously managed conservatively, severe tricuspid regurgitation has progressed to a torrential grade, with right-sided chamber dilatation and complex valve anatomy.

How would you treat this patient?

Live updates on a selection of major Late Breaking Clinical Trials of interest in interventional cardiology presented at the American College of Cardiology 2026 Scientific Sessions #ACC26

This 77-year-old woman with paroxysmal AF and prior GI bleeding is referred for LAA closure, but CT reveals a shallow, inferior chicken-wing morphology that complicates device selection and planning. How would your Heart Team approach this challenging case?