PCR Journal Club

The objective of this substudy was to examine the safety of switching patients with atrial fibrillation (AF) who were previously on warfarin or a direct oral anticoagulant (DOAC) to dabigatran dual therapy.

The study aimed to evaluate the capabilities of correctly detecting episodes of Atrial fibrillation/flutter (Afib) through a smartwatch-based irregular pulse notification algorithm of the Apple watch.

The GALILEO trial was a randomized, open-label, event-driven, international, multicentre trial comparing two different preventive strategies for thromboembolic complications in patients who underwent successful TAVI and had not established indication for oral anticoagulation.

COLCOT was a double-blind RCT, designed to evaluate 0.5 mg oral colchicine daily as compared with placebo in patients within 30 days of acute myocardial infarction.

This study compared the outcomes of TAVR in patients with pure Aortic Stenosis (i.e., without or trivial AR) vs. patients with MAVD (AS associated with mild to moderate or severe AR).

Although multiple studies have demonstrated an early health status benefit with TAVI vs. SAVR , this is the first randomized trial to demonstrate a persistent, albeit modest, health status advantage with TAVI at 6 and 12 months—timepoints at which patients are assumed to have recovered fully...

The results of this study suggest that the use of self-expandable valves could help reduce the incidence of post-procedural PPM after TAVI, especially in the population with large body size...

The GALILEO-4D was a dedicated substudy that sought to evaluate the effect of oral anticoagulation with rivaroxaban on bioprosthetic aortic valve leaflet thickening and motion impairment.

CorMicA was a randomised control trial comparing medical therapy guided by invasive coronary function testing (CFR, IMR and acetylcholine provocation) versus standard care in 151 patients with symptoms and/or signs of ischaemia with no obstructive coronary artery disease (INOCA).

Using the data from the national prospective French registry (FRANCE TAVI), this study compared the characteristics and outcomes of TAVR procedures according to whether they were performed through a femoral or a nonfemoral peripheral access.