Nicolas Van Mieghem
Latest contributions
TAV in TAVI with coronary protection - LIVE Case
18 Nov 2025 – From PCR London Valves 2025
Watch a LIVE case followed by a recorded case, regarding a 78-year-old female, with a previous TAVI in 2014 (Sapien 3 26) and sarcoidosis, who presented with symptomatic TAVI stenosis. There was a mis-commissural alignment, with the neoskirt plane above the coronary plane. Under general anesthesia,...
TAVI - Haemodynamic performance and valve durability
18 Nov 2025 – From PCR London Valves 2025
This session provides an in-depth exploration of haemodynamic performance and valve durability following transcatheter aortic valve implantation (TAVI). Attendees will gain a comprehensive understanding of the differences between invasive and echocardiographic gradients post-TAVI, evaluate the haemodynamic profiles of various transcatheter valve platforms, and appreciate their implications...
Planning a lifetime of care in younger patients with Evolut FX+: from index valve to future options
17 Nov 2025 – From PCR London Valves 2025
Watch this PCR London Valves 2025 session to take a deep look at the latest evidence in low-risk aortic stenosis, the durability of contemporary valves, and how anatomy — especially in women and patients with small annuli — shapes long-term strategy.
From index TAVI with Evolut FX+...
Complex valve-in-valve leaflet modification - LIVE Case
17 Nov 2025 – From PCR London Valves 2025
Watch this LIVE case followed by a recorded case, regarding a 79-year-old male with permanent AF and a history of surgical aortic valve replacement in 2010 (Magna Ease 25) who presented with symptomatic bioprosthetic valve stenosis, normal LV function, and no CAD. A Sapien 3 Ultra...
TAVI for pure aortic regurgitation: different animal, different challenges, different approaches
17 Nov 2025 – From PCR London Valves 2025
This session delves into the unique anatomical and pathophysiological challenges posed by pure aortic regurgitation and their impact on treatment strategies. It reviews clinical outcomes with established and new transcatheter devices, and presents emerging technologies that promise to advance therapeutic options for this distinct patient population.
Featured research: latest advances in mitral TEER and valve repair technologies
16 Nov 2025 – From PCR London Valves 2025
This session presents featured research on mitral valve interventions, including two-year outcomes from the MitraClip G4 EXPAND study, comparative data of mitral TEER versus redo surgery in failed surgical repair, evidence from novel TEER programs in non-surgical centers, and safety and efficacy results of the NeoNova...
Meet the masters: complex TAVI
16 Nov 2025 – From PCR London Valves 2025
This session offers an in-depth exploration of complex Transcatheter Aortic Valve Implantation (TAVI) procedures, emphasizing practical aspects crucial for daily clinical practice. Expert TAVI operators share their extensive experience, providing valuable tips and tricks on case selection, procedural strategies, and managing complications to optimize patient outcomes.
Late-breaking evidence in structural and coronary interventions - Part 2
16 Nov 2025 – From PCR London Valves 2025
This session presents the latest data from pivotal late-breaking trials in interventional cardiology. Highlights include one-year results from the ADALA trial, first-in-man use of the Vivasure PerQseal Elite for large hole arterial closure, two-year outcomes of the DragonFly system in China, six-month European outcomes, and insights...
Innovation to address unmet clinical needs in transcatheter valve therapies
22 May 2025 – From EuroPCR 2025
Discover innovations addressing unmet clinical needs in transcatheter valve therapies. This session shares case-based experiences including young aortic stenosis patients, mitral regurgitation with annular calcification, and severe tricuspid regurgitation with right ventricular dysfunction, alongside the latest advances in TAVI, TMVR, and tricuspid interventions.
Emerging indications for TAVI in 2025
22 May 2025 – From EuroPCR 2025
Prepare for emerging TAVI indications anticipated in 2025. This session reviews clinical cases including asymptomatic severe aortic stenosis, moderate aortic stenosis with heart failure, and severe aortic regurgitation. It discusses supporting evidence from clinical trials, evolving transcatheter technologies, and practical treatment approaches for these novel indications.
Redo TAVI - How to treat different TAVI platforms when they fail
22 May 2025 – From EuroPCR 2025
Understand the complexities of redo TAVI procedures with emphasis on planning, valve platform characteristics, and tailored procedural strategies. This session features cases of redo TAVI for failed short-frame and tall-frame valves, alongside discussions on current evidence gaps guiding optimal management.
Successful finale - Latest best practices and technologies for large hole arterial and venous closure
22 May 2025 – From EuroPCR 2025
This session covers the latest best practices and technologies for large hole arterial and venous closure, focusing on minimising vascular complications.
Learn about a novel patch-based closure system with encouraging early results in TAVI cases, highlighting the importance of deployment angle and ultrasound guidance.
The venous case presentation...
Innovations in TMVR and Intrepid trial updates
21 May 2025 – From EuroPCR 2025
This EuroPCR 2025 session highlights the evolving role of transcatheter mitral valve replacement, focusing on the clinical potential of mitral regurgitation elimination. Get an overview of the current status of the Intrepid TMVR programme, learn about the transition to the 29Fr transfemoral system, and explore how...
Challenges and solutions in an expanding TAVI world
20 May 2025 – From EuroPCR 2025
This EuroPCR 2025 session addresses key challenges and emerging solutions in today’s rapidly evolving TAVI landscape. It presents the latest evidence on valve replacement in low-risk patients with aortic stenosis, alongside strategies for navigating the complexities of lifetime management in TAVI candidates. The programme features a...
What are the emerging indications for TAVI in 2025?
22 May 2025 – From EuroPCR 2025
Tiffany Patterson, Nicolas Van Mieghem, and Philippe Généreux discuss emerging indications for TAVI in 2025. They review recent evidence on asymptomatic severe aortic stenosis, highlighting four randomised trials—RECOVERY, AVATAR, ONLY TAVR, and EVoLVeD—that show TAVI or surgical AVR reduces hospitalisations for heart failure and trends toward...
TAVI for pure aortic regurgitation - LIVE case
25 Nov 2024 – From PCR London Valves 2024
Watch a LIVE case followed by a recorded case on aortic regurgitation:
- An 86-year-old male with a history of stroke and prostate cancer presenting acute heart failure due to severe pure aortic regurgitation and LV dysfunction (EF 39%). A 27 mm JenaValve Trilogy prosthesis was implanted without...
TAVI for aortic regurgitation
25 Nov 2024 – From PCR London Valves 2024
Curious about advancing your knowledge in TAVI for aortic regurgitation? Don’t miss this video!
You'll dive into the diagnostic and treatment strategies to optimize outcomes in patients with aortic regurgitation, explore groundbreaking technologies like the Jenavalve Trilogy THV system and gain insights from the latest clinical evidence and...
Transcatheter mitral valve replacement - Are we there yet?
25 Nov 2024 – From PCR London Valves 2024
Are we ready to embrace transcatheter mitral valve replacement (TMVR) as the next big step in mitral interventions? Find out in this must-watch video!
Discover the key anatomical factors that favor TMVR over TEER, get acquainted with cutting-edge TMVR platforms like Tioga, Cephea and Intrepid, and master...
Electrosurgery and leaflet modification: addressing an unmet need for transcatheter valve interventions
24 Nov 2024 – From PCR London Valves 2024
Electrosurgery and leaflet modification are revolutionizing transcatheter valve interventions, addressing unmet needs for patients who lack conventional treatment options. This video offers a deep dive into the clinical applications of these advanced techniques and equips you with the knowledge to implement them effectively.
You’ll discover:
- How electrosurgical tools,...
Featured research - Aortic valve (Part 1)
24 Nov 2024 – From PCR London Valves 2024
Dive into the latest research on aortic valve interventions in this two-part featured research session. Explore a wide range of topics, including the safety and efficacy of novel transcatheter aortic valve systems, hemodynamic outcomes, risk scoring, and peri-procedural considerations.
Leading innovation for patients with valvular heart disease
24 Nov 2024 – From PCR London Valves 2024
Discover the newest advancements in transcatheter heart valves and their role in modern lifetime management of valvular heart disease. Review the latest clinical outcomes demonstrating improved patient care and explore how a diverse device portfolio addresses a wide range of valve anatomies.
Transcatheter aortic valve replacement in patients with systolic heart failure and moderate aortic stenosis (TAVR UNLOAD)
28 Oct 2024
Mirvat Alasnag interviews Nicolas M. Van Mieghem about the results of the TAVR UNLOAD trial he presented at the TCT Conference 2024.
Author
Author
Identification and treatment of (sub)clinical transcatheter valve thrombosis
16 May 2024 – From EuroPCR 2024
This session offers a practical guide to CT diagnosis of HALT/RLM, highlighting the importance of taking HALT/RLM seriously and providing insights into approaching HALT/HAM and the potential impact of pharmacotherapy. Gain knowledge on determining leaflet thickening and mobility through MSCT, receive updates on antithrombotic treatment strategies...
Transformative imaging in the clinical pathway of transcatheter tricuspid valve interventions
16 May 2024 – From EuroPCR 2024
Explore this EuroPCR 2024 session for a comprehensive understanding of the imaging pathway in transcatheter tricuspid valve interventions, including diagnosis, therapy, and post-procedural follow-up, discover innovative, transformative imaging techniques such as 4D intracardiac echocardiography and dual-source photon-counting CT, and learn how these innovations can be applied in...
Innovation and strategies in TAVI: design, data and directions for clinical practice
15 May 2024 – From EuroPCR 2024
Watch this session to explore considerations for TAVI implantation in small annuli, gain insights into future lifetime management, learn about the benefits of FX technology and clinical evidence beyond small annuli, and witness a live case procedure showcasing the innovation of FX plus. This session is...
TAVI hotline: long-term registry data
15 May 2024 – From EuroPCR 2024
This session presents and discusses long-term registry data on various aspects of transcatheter aortic valve implantation (TAVI). It covers topics such as the surgical versus transcatheter approach in combined coronary and aortic valve disease, long-term outcomes of TAVI versus surgical aortic valve replacement, and registry data...
Align for the future with next-generation balloon expandable THV technology
15 May 2024 – From EuroPCR 2024
In this session, explore the next-generation balloon-expandable Myval Octacor THV, focusing on its key features, procedural impact, and potential clinical benefits. Understand the procedural steps for planning and implanting it, especially for intermediate and extra-large sizes, using the Octalign technique. Learn about the unmet clinical need...
Crossing the finishing line - Latest best practices and technologies for large hole arterial and venous closure
14 May 2024 – From EuroPCR 2024
Tune in to this session for insights on optimizing vascular access and closure techniques. Explore steps like thorough CT analysis, ultrasound-guided puncture, and contingency plans for alternative access methods to minimize complications. Discover a novel patch-based closure approach offering immediate hemostasis and simplified usage, addressing issues...
Clinical experience with DurAVR THV: a new class, biomimetic TAVI
16 May 2024 – From EuroPCR 2024
Join Azeem Latib, Christopher Meduri, and Nicolas Van Mieghem as they explore the history of cutting-edge tissue science in the TAVI space. Learn about the development of a biomimetic aortic valve design and insights from the DurAVR FIH study on this balloon-expandable platform. Discover the link...
An intrepid solution for transfemoral treatment of mitral regurgitation
21 Nov 2023 – From PCR London Valves 2023
In this session, get insights into the APOLLO EU trial and its current progress, obtain a comprehensive understanding of the latest data from the Early Feasibility TF trial, and discern which patients stand to benefit the most from this treatment.
