Nicolas Van Mieghem
Latest contributions
Redo TAVI - How to treat different TAVI platforms when they fail
22 May 2025 – From EuroPCR 2025
Understand the complexities of redo TAVI procedures with emphasis on planning, valve platform characteristics, and tailored procedural strategies. This session features cases of redo TAVI for failed short-frame and tall-frame valves, alongside discussions on current evidence gaps guiding optimal management.
Successful finale - Latest best practices and technologies for large hole arterial and venous closure
22 May 2025 – From EuroPCR 2025
This session covers the latest best practices and technologies for large hole arterial and venous closure, focusing on minimising vascular complications.
Learn about a novel patch-based closure system with encouraging early results in TAVI cases, highlighting the importance of deployment angle and ultrasound guidance.
The venous case presentation...
Emerging indications for TAVI in 2025
22 May 2025 – From EuroPCR 2025
Prepare for emerging TAVI indications anticipated in 2025. This session reviews clinical cases including asymptomatic severe aortic stenosis, moderate aortic stenosis with heart failure, and severe aortic regurgitation. It discusses supporting evidence from clinical trials, evolving transcatheter technologies, and practical treatment approaches for these novel indications.
Innovation to address unmet clinical needs in transcatheter valve therapies
22 May 2025 – From EuroPCR 2025
Discover innovations addressing unmet clinical needs in transcatheter valve therapies. This session shares case-based experiences including young aortic stenosis patients, mitral regurgitation with annular calcification, and severe tricuspid regurgitation with right ventricular dysfunction, alongside the latest advances in TAVI, TMVR, and tricuspid interventions.
Innovations in TMVR and Intrepid trial updates
21 May 2025 – From EuroPCR 2025
This EuroPCR 2025 session highlights the evolving role of transcatheter mitral valve replacement, focusing on the clinical potential of mitral regurgitation elimination. Get an overview of the current status of the Intrepid TMVR programme, learn about the transition to the 29Fr transfemoral system, and explore how...
Challenges and solutions in an expanding TAVI world
20 May 2025 – From EuroPCR 2025
This EuroPCR 2025 session addresses key challenges and emerging solutions in today’s rapidly evolving TAVI landscape. It presents the latest evidence on valve replacement in low-risk patients with aortic stenosis, alongside strategies for navigating the complexities of lifetime management in TAVI candidates. The programme features a...
What are the emerging indications for TAVI in 2025?
22 May 2025 – From EuroPCR 2025
Tiffany Patterson, Nicolas Van Mieghem, and Philippe Généreux discuss emerging indications for TAVI in 2025. They review recent evidence on asymptomatic severe aortic stenosis, highlighting four randomised trials—RECOVERY, AVATAR, ONLY TAVR, and EVoLVeD—that show TAVI or surgical AVR reduces hospitalisations for heart failure and trends toward...
Transcatheter mitral valve replacement - Are we there yet?
25 Nov 2024 – From PCR London Valves 2024
Are we ready to embrace transcatheter mitral valve replacement (TMVR) as the next big step in mitral interventions? Find out in this must-watch video!
Discover the key anatomical factors that favor TMVR over TEER, get acquainted with cutting-edge TMVR platforms like Tioga, Cephea and Intrepid, and master...
TAVI for pure aortic regurgitation - LIVE case
25 Nov 2024 – From PCR London Valves 2024
Watch a LIVE case followed by a recorded case on aortic regurgitation:
- An 86-year-old male with a history of stroke and prostate cancer presenting acute heart failure due to severe pure aortic regurgitation and LV dysfunction (EF 39%). A 27 mm JenaValve Trilogy prosthesis was implanted without...
TAVI for aortic regurgitation
25 Nov 2024 – From PCR London Valves 2024
Curious about advancing your knowledge in TAVI for aortic regurgitation? Don’t miss this video!
You'll dive into the diagnostic and treatment strategies to optimize outcomes in patients with aortic regurgitation, explore groundbreaking technologies like the Jenavalve Trilogy THV system and gain insights from the latest clinical evidence and...
Electrosurgery and leaflet modification: addressing an unmet need for transcatheter valve interventions
24 Nov 2024 – From PCR London Valves 2024
Electrosurgery and leaflet modification are revolutionizing transcatheter valve interventions, addressing unmet needs for patients who lack conventional treatment options. This video offers a deep dive into the clinical applications of these advanced techniques and equips you with the knowledge to implement them effectively.
You’ll discover:
- How electrosurgical tools,...
Leading innovation for patients with valvular heart disease
24 Nov 2024 – From PCR London Valves 2024
Discover the newest advancements in transcatheter heart valves and their role in modern lifetime management of valvular heart disease. Review the latest clinical outcomes demonstrating improved patient care and explore how a diverse device portfolio addresses a wide range of valve anatomies.
Featured research - Aortic valve (Part 1)
24 Nov 2024 – From PCR London Valves 2024
Dive into the latest research on aortic valve interventions in this two-part featured research session. Explore a wide range of topics, including the safety and efficacy of novel transcatheter aortic valve systems, hemodynamic outcomes, risk scoring, and peri-procedural considerations.
Transcatheter aortic valve replacement in patients with systolic heart failure and moderate aortic stenosis (TAVR UNLOAD)
28 Oct 2024
Mirvat Alasnag interviews Nicolas M. Van Mieghem about the results of the TAVR UNLOAD trial he presented at the TCT Conference 2024.
Author
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Transformative imaging in the clinical pathway of transcatheter tricuspid valve interventions
16 May 2024 – From EuroPCR 2024
Explore this EuroPCR 2024 session for a comprehensive understanding of the imaging pathway in transcatheter tricuspid valve interventions, including diagnosis, therapy, and post-procedural follow-up, discover innovative, transformative imaging techniques such as 4D intracardiac echocardiography and dual-source photon-counting CT, and learn how these innovations can be applied in...
Identification and treatment of (sub)clinical transcatheter valve thrombosis
16 May 2024 – From EuroPCR 2024
This session offers a practical guide to CT diagnosis of HALT/RLM, highlighting the importance of taking HALT/RLM seriously and providing insights into approaching HALT/HAM and the potential impact of pharmacotherapy. Gain knowledge on determining leaflet thickening and mobility through MSCT, receive updates on antithrombotic treatment strategies...
Align for the future with next-generation balloon expandable THV technology
15 May 2024 – From EuroPCR 2024
In this session, explore the next-generation balloon-expandable Myval Octacor THV, focusing on its key features, procedural impact, and potential clinical benefits. Understand the procedural steps for planning and implanting it, especially for intermediate and extra-large sizes, using the Octalign technique. Learn about the unmet clinical need...
TAVI hotline: long-term registry data
15 May 2024 – From EuroPCR 2024
This session presents and discusses long-term registry data on various aspects of transcatheter aortic valve implantation (TAVI). It covers topics such as the surgical versus transcatheter approach in combined coronary and aortic valve disease, long-term outcomes of TAVI versus surgical aortic valve replacement, and registry data...
Innovation and strategies in TAVI: design, data and directions for clinical practice
15 May 2024 – From EuroPCR 2024
Watch this session to explore considerations for TAVI implantation in small annuli, gain insights into future lifetime management, learn about the benefits of FX technology and clinical evidence beyond small annuli, and witness a live case procedure showcasing the innovation of FX plus. This session is...
Crossing the finishing line - Latest best practices and technologies for large hole arterial and venous closure
14 May 2024 – From EuroPCR 2024
Tune in to this session for insights on optimizing vascular access and closure techniques. Explore steps like thorough CT analysis, ultrasound-guided puncture, and contingency plans for alternative access methods to minimize complications. Discover a novel patch-based closure approach offering immediate hemostasis and simplified usage, addressing issues...
Clinical experience with DurAVR THV: a new class, biomimetic TAVI
16 May 2024 – From EuroPCR 2024
Join Azeem Latib, Christopher Meduri, and Nicolas Van Mieghem as they explore the history of cutting-edge tissue science in the TAVI space. Learn about the development of a biomimetic aortic valve design and insights from the DurAVR FIH study on this balloon-expandable platform. Discover the link...
Finishing strong - Latest best practices and technologies for large hole arterial and venous closure
21 Nov 2023 – From PCR London Valves 2023
Consult this session to grasp the current landscape of techniques for closing large holes in both arterial and venous contexts. Acquire valuable tips and tricks aimed at minimizing vascular complications, and learn about the innovative patch-based closure approach for a comprehensive understanding.
An intrepid solution for transfemoral treatment of mitral regurgitation
21 Nov 2023 – From PCR London Valves 2023
In this session, get insights into the APOLLO EU trial and its current progress, obtain a comprehensive understanding of the latest data from the Early Feasibility TF trial, and discern which patients stand to benefit the most from this treatment.
TAVI in complex scenarios - Valve-in-valve TAVI (TAV-in-SAV) - A tailored approach
20 Nov 2023 – From PCR London Valves 2023
This session is designed for those seeking an understanding of critical imaging principles in planning successful TAV-in-SAV procedures. Gain insights into the latest tools for pre-procedural imaging and learn how to develop customized algorithms for selecting transcatheter heart valves in individual patients undergoing TAV-in-SAV interventions.
Transcatheter mitral valve replacement - The wait will be worth it
20 Nov 2023 – From PCR London Valves 2023
Reflect on the past decade of Transcatheter Mitral Valve Replacement (TMVR) to uncover technical and clinical challenges and the lessons they've taught. Explore innovative technologies addressing persistent issues, offering solutions and anticipated timelines. Additionally, delve into the present and future trial designs, exploring the evidence required for...
Valve performance and durability - Main considerations in selecting the right TAVI valve
20 Nov 2023 – From PCR London Valves 2023
In this session with LIVE case, participants discuss the critical role of valve selection in influencing patient outcomes. The focus includes understanding the latest clinical outcomes of supra-annular TAVI and SAVR, exploring their practical implications. The session also highlights the contribution of novel technology Evolut FX, in...
Transcatheter mitral repair and replacement for primary mitral regurgitation - LIVE case
19 Nov 2023 – From PCR London Valves 2023
This session aims to highlight the remarkable advancements achieved in transcatheter mitral valve intervention over the past two decades, since its inception. Follow two TEER cases which illustrate this rapidly growing field:
- Transcatheter edge-edge mitral valve repair
A 77-year-old male with a history of SAVR (bioprothesis) + LIM-LAD/Diag, normal...
TAVI and beyond: tackling coronary challenges
19 Nov 2023 – From PCR London Valves 2023
Consult this session to gain a comprehensive understanding of the crucial role of coronary access post-TAVI, and the impact of TAV design and implantation technique on coronary access. Gain some insights into the intricacies of coronary accessibility from extensive bench test work and the impact of TAV design in...
TAVI: haemodynamic considerations
19 Nov 2023 – From PCR London Valves 2023
Consult this session to gain a comprehensive understanding of the hemodynamic considerations in TAVI: delve into the comparative analysis of invasive and echocardiographic assessments to discern transvalvular pressure gradients post-TAVI, witness the validation of non-invasive volume-pressure loop analysis as an effective tool for patients with aortic...
Innovations in TMVR and Intrepid trial updates
18 May 2023 – From EuroPCR 2023
This session explores the innovations in Transcatheter Mitral Valve replacement, with a special focus on the updates from the INTREPID and APOLLO EU trial, as well as patient benefits through case studies.
