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Clinical and echocardiographic outcomes among the first 500 patients treated with a dedicated transcatheter aortic valve for pure aortic regurgitation in the Align-AR clinical trial

31 Mar 2025

Jonathan Curio interviews Raj Makkar about the results of the Align-AR trial which he presented during the ACC.25 in Chicago.

Jonathan Curio

Author

Jonathan Curio
Raj Makkar

Author

Raj Makkar
Clinical and echocardiographic outcomes among the first 500 patients treated with a dedicated transcatheter aortic valve for pure aortic regurgitation in the Align-AR clinical trial

PCR London Valves 2022 was an incredible success, with over 3,500 participants!

View great snapshots, opening and closing videos, key facts and figures on valvular community!
Best of PCR London Valves 2022

The 2023 top Japanese abstracts

18 Feb 2023 – From PCR Tokyo Valves 2023

Explore the cutting-edge research showcased in the top Japenese abstracts of PCR Tokyo Valves 2023. Uncover profound insights, including a detailed examination of three-year outcomes in 500 patients treated with MitraClip, a comparative analysis of outcomes between COMBO therapy and transcatheter edge-to-edge repair for severe mitral...

Hotline - ACURATE neo2 under-expansion in the ACURATE IDE study: a post-hoc analysis

21 May 2025 – From EuroPCR 2025

Howard Herrmann and Raj Makkar discuss a sub-study of the ACURATE IDE trial, which examined valve under-expansion detected by fluoroscopy. Among 1,500 patients with aortic stenosis, 22 % of ACURATE neo2 valves showed under-expansion, often linked to heavy valve calcification.

Patients with under-expanded valves faced higher risks...

ACURATE neo2 under-expansion in the ACURATE IDE study: a post-hoc analysis

Triluminate trial: deep dive into the outcomes

In this video, members of the PCR Tricuspid Focus Group Nicole Karam and Ralph Stephan von Bardeleben talk with David Adams and Paul Sorajja about the first landmark trial in the field of tricuspid valve disease, Triluminate. Together they discuss the results presented during the ACC.23/WCC...

Triluminate trial: deep dive into the outcomes

Tricuspid TEER: learnings from the 2-year outcomes of TRILUMINATE Pivotal trial & bRIGHT study

20 May 2025 – From EuroPCR 2025

At EuroPCR 2025, Marianna Adamo and Ralph Stephan von Bardeleben discussed the latest findings on tricuspid valve repair using transcatheter edge-to-edge repair (TEER).

The 2-year results from the TRILUMINATE Pivotal trial showed a significant reduction in tricuspid regurgitation, lasting improvements in quality of life, and a notable...

Tricuspid TEER: learnings from the 2-year outcomes of TRILUMINATE Pivotal trial & bRIGHT study

GulfPCR-GIM 2019 Award and Closing Ceremony

19 Dec 2019 – From GulfPCR-GIM 2019

Consult this session to see the slides presented during GulfPCR-GIM 2019 Award and Closing Ceremony, which gathered 832 active participants, and discover who the best clinical case award winner was that year.

GulfPCR-GIM 2019 Award and Closing Ceremony

Minimally invasive mitral valve repair case - Session with LIVE case

23 Nov 2020 – From PCR Valves e-Course

View this virtual LIVE case surgery recorded in Leipzig Heart Center, Germany – followed by LIVE call-ins from different city pods around the globe.

This session was originally presented during PCR Valves e-Course 2020.

Minimally invasive mitral valve repair case - Session with LIVE case

PCR Valves e-Course 2020 closing ceremony

24 Nov 2020 – From PCR Valves e-Course 2020

On behalf of the Core Team, Bernard Prendergast thanks those who participated and contributed to PCR Valves e-Course 2020. During three days, imaging specialists, interventionists, cardiac surgeons and Heart Valve Teams from all across the world shared their knowledge, experience and practice, contributing to reinventing education and...

Closing ceremony

Minimally invasive tricuspid valve repair and MAZE case from Leipzig Heart Center - Leipzig, Germany

24 Nov 2020 – From PCR Valves e-Course 2020

View this virtual LIVE case surgery recorded in Leipzig Heart Center, Germany – followed by LIVE call-ins from different city pods around the globe.

A 67-year-old low-risk active lady with severe tricuspid regurgitation, persistent atrial fibrillation with dilated atria and moderate RV dilatation but preserved RVEF.

This session...

Minimally invasive tricuspid

PCR e-Course 2020 Closing Ceremony: reinventing education in interventional cardiovascular medicine!

28 Jun 2020 – From PCR e-Course 2020

On behalf of the Core Team and the 271 e-Faculty members, Davide Capodanno, Jean Fajadet and William Wijns thank those who attended and participated in - as well as contributed to - PCR e-Course 2020. At a time when exchange with peers and extended networks like...

PCR e-Course 2020 Closing Ceremony:

PCR Valves e-Course 2020: Opening Ceremony

22 Nov 2020 – From PCR Valves e-Course 2020

Get a feel of the positive vibrations at #PCRvalves by watching a recording of the Opening ceremony, which was broadcast live from 3 TV studios in London, Paris and Toulouse! It shares how the comprehensive and innovative 3-day e-Course on the 3 valves – aortic, mitral...

PCR Valves e-Course 2020: Opening Ceremony

TAVI in bicuspid case from London Bridge Hospital, London, United Kingdom - Session with LIVE case

22 Nov 2020 – From PCR Valves e-Course 2020

A 77-year-old low-risk female patient with symptomatic aortic stenosis and bicuspid valve, suitable for TF access...

View this virtual LIVE case transcatheter intervention recorded in London Bridge Hospital, London, United Kingdom – followed by LIVE call-ins from different city pods around the globe.

This session was originally presented during...

Virtual LIVE - TAVI in bicuspid case

Minimally invasive aortic valve and ascending aortic replacement case from Leipzig Heart Center - Leipzig, Germany - Session with LIVE case

22 Nov 2020 – From PCR Valves e-Course 2020

A 62-year-old active male with severe stenosis of bicuspid aortic valve, ascending aortic aneurysm and obesity…

View this virtual LIVE case surgery recorded in Leipzig Heart Center, Germany – followed by LIVE call-ins from different city pods around the globe.

This session was originally presented during PCR Valves...

Virtual LIVE - Minimally invasive aortic valve and ascending aortic replacement

LAD/D1 bifurcation disease

06 Jul 2019 – From AICT-AsiaPCR 2019

Consult this session to discover the key clinical data and angiographic reference of a patient presenting with LAD/D1 bifurcation disease.

LAD/D1 bifurcation disease

A patient with LAD-diagonal bifurcation lesion

22 May 2019 – From EuroPCR 2019

A patient with LAD-diagonal

TAVI device selection for severe aortic stenosis - Session with LIVE case

18 Nov 2019 – From PCR London Valves 2019

Watch this session with a LIVE demonstration from University Hospital of Zurich (Zurich, Switzerland) to learn more about TAVI device selection and « Best practice » implantation of the Portico Valve.

TAVI device selection

Transcatheter mitral valve-in-valve for a patient with a degenerating bioprosthesis - Session with LIVE case

18 Nov 2019 – From PCR London Valves 2019

Watch this session with a LIVE demonstration from St Thomas' Hospital - London, United Kingdom

Transcatheter mitral

Calcified lesions

05 Jul 2019 – From AICT-AsiaPCR 2019

Watch this LIVE demonstration from National University Heart Centre (Singapore) to discover how they managed the case of a 69 years-old male with diabetes, hypertension and hyperlipidemia suffering from a calcified triple vessel disease.

Calcified lesions

Diffuse multivessel disease

05 Jul 2019 – From AICT-AsiaPCR 2019

Diffuse multivessel disease
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