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Hotline - TAVI - Part 1

16 Nov 2025 – From PCR London Valves 2025

This comprehensive session examines the latest evidence and clinical trial data on TAVI, including comparisons of balloon-expandable versus self-expanding valves in failed bioprostheses, techniques to reduce coronary obstruction risk, and real-world outcomes across diverse populations. Cost-effectiveness analyses and longitudinal studies further inform best practices for optimizing...

Breakout session on Simul-Imaging

16 Nov 2025 – From PCR London Valves 2025

This session focuses on the evolution and impact of simul-imaging in interventional cardiology. It reviews historical perspectives on the FIM procedure, the role of simulation in accelerating the learning curve, and innovative approaches to simulation-based training. Additionally, the session highlights cutting-edge imaging innovations from major industry...

Valve interventions in congenital heart disease

16 Nov 2025 – From PCR London Valves 2025

This session presents complex valve interventions in congenital heart disease, highlighting challenging cases such as positional hypoxaemia due to iatrogenic atrial defects, navigating residual shunts after PFO closure, and transcatheter pulmonary valve replacement in native right ventricular outflow tracts without pre-stenting. It also examines an intriguing...

TAVI in aortic regurgitation

16 Nov 2025 – From PCR London Valves 2025

This session addresses the challenges and innovations in transcatheter aortic valve implantation (TAVI) for aortic regurgitation. It covers complex clinical scenarios such as severe regurgitation post-endocarditis, alternative access routes complicated by prosthesis embolisation, and the use of dedicated TAVI devices in non-tricuspid valves. The session also...

TAVI-in-TAVI

16 Nov 2025 – From PCR London Valves 2025

This session explores the nuanced field of TAVI-in-TAVI procedures, focusing on valve durability considerations between bovine and porcine valves, strategies for redo TAVI post valve-in-valve, and advanced interventions to secure coronary flow such as inter-valvular stenting. It highlights complex anatomical challenges including aberrant coronary origins and...

Advancing structural heart with 3D ICE and device guidance

17 Nov 2025 – From PCR London Valves 2025

This PCR London Valves 2025 session explores how 3D TEE, 3D intracardiac echocardiography (ICE), and DeviceGuide technology sharpen procedural accuracy, strengthen operator confidence, and streamline decision-making in real time.

You’ll see how clearly defined team roles enhance both safety and efficiency, and how thoughtful workflow integration can reduce...

Advancing structural heart with 3D ICE and device guidance

Curious mitral and tricuspid scenarios

16 Nov 2025 – From PCR London Valves 2025

This session presents a series of challenging and unusual clinical scenarios involving mitral and tricuspid valve disease. Topics include management of acute primary mitral regurgitation in high-surgical-risk patients, technical challenges in transcatheter mitral valve replacement (TMVR), and complex cases where cardiac rhythm disturbances interplay with valvular...

Align for the future with next gen Myval transcatheter heart valve series

16 Nov 2025 – From PCR London Valves 2025

Discover how the latest Myval transcatheter heart valve (THV) innovations are shaping TAVI outcomes. This PCR London Valves 2025 session highlights the clinical evidence behind the next-gen Myval THV series, best practices for implantation, and upcoming innovations set to improve patient care. Learn step-by-step techniques for deploying Myval...

Align for the future with next gen Myval transcatheter heart valve series

Day case TAVI - The future standard of care for most TAVI patients

16 Nov 2025 – From PCR London Valves 2025

Examining the UK experience, this session discusses the emerging standard of day case TAVI and its potential application across Europe. It evaluates patient-centered risks and benefits, operational requirements, and the evolving role of clinical valve coordinators to facilitate safe and efficient day case pathways for TAVI...

Day case TAVI - The future standard of care for most TAVI patients

Exceptional engineering, predictable outcomes - Latest development of the VitaFlow TAVI device

17 Nov 2025 – From PCR London Valves 2025

Discover the latest advancements in the VitaFlow transcatheter aortic valve implantation (TAVI) device. This session highlights the electronically enabled VitaFlow Liberty system, delivering consistent immediate and mid-term clinical results. Watch real-world demonstrations of complex cases, including heavily calcified aortas and pure aortic regurgitation, and get a...

Exceptional engineering, predictable outcomes - Latest development of the VitaFlow TAVI device

Featured research: latest advances in mitral TEER and valve repair technologies

16 Nov 2025 – From PCR London Valves 2025

This session presents featured research on mitral valve interventions, including two-year outcomes from the MitraClip G4 EXPAND study, comparative data of mitral TEER versus redo surgery in failed surgical repair, evidence from novel TEER programs in non-surgical centers, and safety and efficacy results of the NeoNova...

Featured research: latest advances in mitral TEER and valve repair technologies

Beyond TAVI

16 Nov 2025 – From PCR London Valves 2025

This session offers a glimpse into cutting-edge structural heart interventions beyond TAVI. It introduces novel devices in early development stages targeting aortic valve stenosis and leaflet modification, discusses strategies to facilitate or defer TAVI, and provides opportunities for engagement with early-stage start-up partners innovating in structural...

Hot topics in structural heart: addressing patients' unmet needs with EVOQUE TTVR and SAPIEN THV-in-THV

17 Nov 2025 – From PCR London Valves 2025

This session addresses emerging topics in structural heart disease by examining patient-centered solutions such as EVOQUE transcatheter tricuspid valve replacement (TTVR) and SAPIEN transcatheter heart valve-in-heart valve (THV-in-THV) procedures. It covers the latest data from Europe on redo TAVI, lifetime management strategies beginning with initial prosthesis...

Hot topics in structural heart: addressing patients' unmet needs with EVOQUE TTVR and SAPIEN THV-in-THV

TAVI: nightmare in the cathlab - Cardiac arrest, aortic root rupture & duct occluder

16 Nov 2025 – From PCR London Valves 2025

Explore critical complications encountered during TAVI procedures in this session, which highlights urgent scenarios such as cardiac arrest from calcific leaflet shift, aortic root rupture, and embolisation events. It also covers salvage techniques like TAVR-in-TAVR-in-SAVR in cardiogenic shock and management of acute left main occlusion with...

TAVI: nightmare in the cathlab - Cardiac arrest, aortic root rupture & duct occluder

TAVI: high coronary risk

16 Nov 2025 – From PCR London Valves 2025

This session addresses the complexities and innovative approaches to managing high coronary risk during TAVI procedures. It features advanced techniques such as the double chimney-stent method, valve-in-valve strategies to prevent coronary obstruction, and challenging cases involving TAVI-in-TAVI. These insights provide practical guidance for interventionalists navigating high-risk...

LAA closure is evolving: are you ready?

17 Nov 2025 – From PCR London Valves 2025

This session addresses the evolving landscape of left atrial appendage (LAA) closure in stroke prevention for atrial fibrillation patients. It reviews unmet clinical needs, evaluates the latest evidence and guideline recommendations, and identifies patient populations that benefit most from LAA closure, with discussions on balancing efficacy...

LAA closure is evolving: are you ready?

Complex combined interventions

16 Nov 2025 – From PCR London Valves 2025

This session presents complex combined interventions tackling multiple valvular and structural heart challenges simultaneously. It highlights innovative procedural approaches such as the 'super combo' techniques, strategies for managing deteriorative mitral regurgitation post-tricuspid valve replacement, and comprehensive management of torrential tricuspid regurgitation within rheumatic multivalvular disease contexts,...

Mastering complex TAVI: overcoming key clinical challenges and achieving optimal outcomes with the Evolut FX+

17 Nov 2025 – From PCR London Valves 2025

This session offers an in-depth review of complex TAVI cases, focusing on overcoming clinical challenges and achieving optimal outcomes with the Evolut FX+ device. Participants will learn about recent advances in TAVI indications for younger and asymptomatic patients, strategies for managing TAV in surgical aortic valve...

Mastering complex TAVI: overcoming key clinical challenges and achieving optimal outcomes with the Evolut FX+

PACMAN AMI: Effects of Alirocumab on Coronary Atherosclerosis Assessed by Serial Multimodality Intracoronary Imaging in Patients With Acute Myocardial Infarction

03 Apr 2022

Nicola Ryan provides a PICOT analysis of PACMAN AMI: a double-blind, placebo-controlled, randomized trial presented at ACC 2022 and simultaneously published in JAMA.

Nicola Ryan

Author

Nicola Ryan
PACMAN AMI: Effects of Alirocumab on Coronary Atherosclerosis Assessed by Serial Multimodality Intracoronary Imaging in Patients With Acute Myocardial Infarction: A Double-blind, Placebo-controlled, Randomized Trial
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