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Clinical trial design

24 Sep 2025

Randomized clinical trials (RCTs) are the cornerstone of modern evidence-based medicine. The primary objective of an RCT is to provide unbiased estimates of the comparative efficacy and safety of various treatments and/or interventions. Interventional cardiology has undoubtedly been at the forefront of clinical research, with a...

Authors :

Sergio Buccheri, Stefan James
The PCR Textbook on clinical trial design

Calcium nodule in circumflex ostium: a complex problem

31 Oct 2025

Analyse this case of an 83-year-old male patient, hypertensive, ex-smoker, with severe COPD and peripheral arterial disease with unstable angina. Coronary angiography revealed a severely calcified lesion in a complex anatomical area, making revascularisation a therapeutic challenge.

Jorge Perea

Author

Jorge Perea
Javier Suarez de Lezo

Author

Javier Suarez de Lezo
Soledad Ojeda

Author

Soledad Ojeda
Prof. Manuel Pan

Author

Manuel Pan
Calcium nodule in circumflex ostium: a complex problem

The Euro4C 2026 Annual Meeting Programme Revealed

Dive into the interactive Programme using the handy filters to find key information such as session titles and objectives related to your topics of interest, in glance or list format.

World Heart Day 2025: the Heart Team beyond the Cathlab

29 Sep 2025

September 29th marks the 25th anniversary of the creation of World Heart Day by the World Heart Federation. This day is dedicated to focusing international attention on cardiovascular disease (CVD), which remains one of the leading causes of mortality worldwide [1,2]. Today, we highlight the women...

World Heart Day 2025 - the Heart Team beyond the Cathlab

PCR @ TCT 2025 - Get the international perspective!

15 Oct 2025

Thanks to the contribution of a team of interventional cardiologists from around the globe, get the international perspective on Late-breaking Clinical Trials and Science released at TCT 2025 - check out the list below.

PCRonline @ TCT 2025 - get the international perspective!

Shanthosh Sivapathan

Kingswood, Australia

Shanthosh Sivapathan

Aadil Bashir Wasil

Kolkata, India

Aadil Bashir Wasil

Positive 3-year results from FIRE Trial demonstrate Supraflex Cruz’s safety and efficacy in elderly heart attack patients

26 Sep 2025

Best of AICT-AsiaPCR 2025

Relive the highlights of AICT-AsiaPCR 2025 in Singapore. Explore photos, videos, replays, and key figures that shaped this year’s Course.

Vinayak Vadgaonkar

Bahrain

Addressing challenges in the right heart

11 Sep 2025 – From PCR Rio Valves 2025

This session addresses complex challenges associated with right heart conditions, featuring cases such as post-infarction interventricular septal defect with right heart failure, innovative orthotopic options for tricuspid regurgitation, and advanced edge-to-edge repair using the TRICLIP device. Gain insight into therapeutic strategies for managing severe tricuspid insufficiency...

Management of aortic stenosis: what really matters before and after the procedure

11 Sep 2025 – From PCR Rio Valves 2025

Aortic stenosis management is a lifetime strategy, not a one-time procedure. This session covers key decision-making factors, compares surgical and transcatheter options, and provides guidance on post-procedural care. Learn to individualise treatment based on age, anatomy, and risk, and plan interventions with the patient’s long-term trajectory...

Management of aortic stenosis: what really matters before and after the procedure

Problem-solving in challenging TAVI cases

11 Sep 2025 – From PCR Rio Valves 2025

Explore complex and challenging TAVI cases with expert-led discussions covering redo TAVI procedures, horizontal aorta anatomy, rapid pacing protocols, lithotripsy-assisted interventions for severe calcific stenosis, and management of procedural complications including valve dislodgement.

Redefining and optimising LAA closure - LIVE Case

11 Sep 2025 – From PCR Rio Valves 2025

Supported by an unrestricted educational grant from Boston Scientific

A 78-year-old woman with atrial fibrillation and obesity (BMI 34.3), normal left ventricular function, CHADS-VASCs 5 and HAS-BLED 4, presented with severe gastrointestinal bleeding.

She underwent implantation of a Watchman FLX™ pro under local anesthesia via two right femoral...

Redefining and optimising LAA closure - LIVE Case

Mitral challenges: from paravalvular leaks to valve-in-valve

12 Sep 2025 – From PCR Rio Valves 2025

Explore complex mitral valve challenges including paravalvular leaks, valve-in-valve implantation, and comprehensive percutaneous cardiac reconstructions. This session highlights innovative percutaneous solutions for surgical no-go zones, haemolytic leaks, and multi-territory device therapies to improve patient outcomes.

TAVI in complex anatomy: high stakes and tight spaces

12 Sep 2025 – From PCR Rio Valves 2025

Address the high-stakes challenges of TAVI in complex anatomical scenarios. This session discusses high-risk valve-in-valve interventions, management of delayed coronary obstruction, procedures in small annuli, and innovative bailout strategies including carotid TAVI.

Tricuspid valve - How to evaluate?

12 Sep 2025 – From PCR Rio Valves 2025

This session offers a detailed evaluation framework for the tricuspid valve, encompassing clinical decision-making, anatomical assessment with 2D and 3D imaging, quantification of regurgitation, and differentiation of secondary and device-related tricuspid regurgitation, supported by advanced imaging software techniques.

TAVI outcomes in special clinical settings: cancer, diabetes, and frailty

12 Sep 2025 – From PCR Rio Valves 2025

Delve into the complexities of TAVI outcomes in special clinical populations including patients with cancer, diabetes, and frailty. This session reviews critical analyses and meta-analyses addressing ischemic cerebrovascular events post-TAVI, and compares mortality and post-procedural outcomes between diabetic and non-diabetic patients, providing valuable insights for personalized...

TMVR today: devices, challenges, and clinical learnings

12 Sep 2025 – From PCR Rio Valves 2025

Explore the evolving landscape of transcatheter mitral valve replacement (TMVR) with a focus on innovative devices, procedural challenges, and clinical learnings. Through a series of case reports, including novel atrial fixation prostheses, devices addressing left ventricular outflow tract obstruction, and complex MitraClip interventions, this session highlights...

Seal the deal: echocardioraphy-guided LAA closure for stroke defense

12 Sep 2025 – From PCR Rio Valves 2025

This session focuses on echocardiography-guided left atrial appendage (LAA) closure as a critical strategy for stroke prevention. Attendees will explore optimal cardiac imaging techniques tailored to evolving clinical needs and seasonal considerations. The session also includes comprehensive instruction on post-procedural echocardiographic assessment and post-processing workflows in...

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