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20 May 2026

First-in-human studies in cardiovascular devices: from first 10 patients to global innovation — How efficient early studies advance emerging technologies

in partnership with Clinical Accelerator

Anchorperson: N. NIKITIN
Discussants: A. Latib, T. Modine, A. Kaplan, D. Burkhoff
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Summary

Understand the pivotal role of first-in-human studies in advancing cardiovascular device innovation through operational insights from early patient experiences. This session reviews cutting-edge technologies including percutaneous left ventricular assist devices, transcatheter leaflet augmentation, physiology-guided PCI, synchronized diaphragmatic stimulation, pulmonary artery denervation, and perspectives on translating early clinical experience into broader clinical momentum.

Presentations available when logged in:

  • Why the first 10 patients matter: operational lessons from early device studies
  • Early experience from the first-in-human study of a novel transcatheter leaflet augmentation device for functional mitral regurgitation.
  • First experience with physiology-guided PCI using real-time coronary flow velocity measurement.
  • Synchronized diaphragmatic stimulation for chronic heart failure with reduced ejection fraction: a first-in-patient experience
  • First experience with pulmonary artery denervation technology for pulmonary hypertension due to left heart disease
  • A physician’s perspective: turning first-in-human experience into clinical momentum