How will the ALL‑RISE randomised trial evaluating angiography‑derived FFR impact our practice?

Rasha Al-Lamee and Margaret Mcentegart review the results of the ALL‑RISE randomised trial, evaluating angiography-derived FFR (FFRangio) compared with wire-based physiology. The study demonstrated non-inferiority in clinical outcomes at one year, while offering significant advantages in terms of workflow, including reduced procedure time, fluoroscopy, and contrast use. Beyond trial results, they highlight the growing adoption of angiography-derived physiology in daily practice, with the potential to simplify procedures and increase the use of physiological assessment in the cath lab. Looking ahead, this technology may represent the next step in coronary physiology, reducing reliance on invasive wires and expanding access to functional assessment worldwide.

This interview was filmed at EuroPCR 2026: see more videos here.