Darren Mylotte
Latest contributions
EuroIntervention Case Reports
18 Mar 2026
The first peer-reviewed Open Access journal dedicated to interventional cardiology is now accepting submissions. Contribute to the first edition of EuroIntervention Case Reports by sharing your clinical knowledge.
PCR Tokyo Valves 2026 Welcome Ceremony
14 Feb 2026 – From PCR Tokyo Valves 2026
The Welcome Ceremony marks the commencement of the conference, setting the stage for an engaging and informative program dedicated to advances in cardiology and interventional techniques. It provides attendees with an overview of the event's objectives and highlights the collaborative spirit of the cardiology community.
Procedural optimisation for enhanced acute and long-term outcomes
14 Feb 2026 – From PCR Tokyo Valves 2026
This session emphasizes procedural optimization in TAVI to enhance both acute and long-term outcomes. It highlights critical factors such as valve sizing, expansion, implantation depth, and commissural alignment. Practical techniques for pre- and post-dilatation alongside commissural alignment are demonstrated through real cath lab cases, underscoring their...
Prevention and management of TAVI complications
14 Feb 2026 – From PCR Tokyo Valves 2026
This session addresses the prevention and management of major complications associated with transcatheter aortic valve implantation (TAVI). Attendees will gain a detailed understanding of mechanisms behind cerebral infarction, haemolysis, valve infolding, pacemaker implantation, and valve migration, along with expert strategies for recognition, decision-making, and bailout techniques...
Patient-tailored treatment for bicuspid valve
14 Feb 2026 – From PCR Tokyo Valves 2026
Delve into patient-tailored treatment strategies for bicuspid aortic valve stenosis, focusing on evidence-based valve selection and sizing for TAVI candidates. This session reviews current device options, procedural planning considerations, and case studies illustrating the use of balloon-expanding and self-expanding valves, emphasizing challenges posed by unfavourable bicuspid...
Mitral and aortic transcatheter valve-in-valve intervention - LIVE case
14 Feb 2026 – From PCR Tokyo Valves 2026
Live case
An 83-year-old male with AF, CKD (stage 3A), preserved LV function, and a history of AVR (27 mm Magna Ease) and MVR (33 mm Magna) in 2014 presented with symptomatic stenosis of the mitral bioprosthesis. A Sapien 3 valve was implanted in the Magna mitral...
Mastering techniques from basic to complex - Advanced TAVI
13 Feb 2026 – From PCR Tokyo Valves 2026
Explore advanced TAVI topics including valve selection for small annuli, optimization strategies for bicuspid aortic valve interventions, and techniques ensuring safety and efficacy in valve-in-valve procedures.
Mastering techniques from basic to complex - Avoidance and management of TAVI complications
13 Feb 2026 – From PCR Tokyo Valves 2026
Address the challenges posed by complex TAVI complications through expert discussion on prevention, management, and bailout techniques. This session covers critical complications such as annulus rupture, stroke, conduction disturbances, and vascular events.
Mastering techniques from basic to complex - TAVI basics
13 Feb 2026 – From PCR Tokyo Valves 2026
This session offers a comprehensive overview of Transcatheter Aortic Valve Implantation (TAVI) fundamentals, focusing on CT scan analysis for optimal patient and valve selection, strategies to avoid procedural complications, and approaches to streamline TAVI procedures for improved outcomes.
TAV in TAVI with coronary protection - LIVE Case
18 Nov 2025 – From PCR London Valves 2025
Watch a LIVE case followed by a recorded case, regarding a 78-year-old female, with a previous TAVI in 2014 (Sapien 3 26) and sarcoidosis, who presented with symptomatic TAVI stenosis. There was a mis-commissural alignment, with the neoskirt plane above the coronary plane. Under general anesthesia,...
Exceptional engineering, predictable outcomes - Latest development of the VitaFlow TAVI device
17 Nov 2025 – From PCR London Valves 2025
Discover the latest advancements in the VitaFlow transcatheter aortic valve implantation (TAVI) device. This session highlights the electronically enabled VitaFlow Liberty system, delivering consistent immediate and mid-term clinical results. Watch real-world demonstrations of complex cases, including heavily calcified aortas and pure aortic regurgitation, and get a...
Patient-tailored TAVI in bicuspid and tricuspid aortic stenosis
16 Nov 2025 – From PCR London Valves 2025
This session focuses on patient-tailored TAVI strategies for bicuspid and tricuspid aortic stenosis. It reviews recent comparative studies of TAVI devices, discusses the development of individualized TAVI programs for tricuspid aortic stenosis patients, and provides guidance on selecting optimal devices for those with bicuspid aortic valve...
Bicuspid disease - All you need to know
16 May 2024 – From EuroPCR 2024
This session is ideal if you want to understand the anatomical features of bicuspid aortic stenosis, learn about the latest post-TAVI clinical outcomes in bicuspid aortic valves, grasp key considerations for TAVI sizing in these cases, and analyze both self-expanding and balloon-expandable TAVI procedures in bicuspid...
Planning for a lifetime starts with choosing the right valve first: from first TAVI to redo-TAVI
15 May 2024 – From EuroPCR 2024
Watch this session to learn the best practices for treating aortic stenosis, with a focus on lifetime management. Gain insights into evaluating patient anatomy and clinical presentation to anticipate the need for a second valve, understand different valve designs and their initial selection, and observe a...
Contemporary TAVI: the VISION of lifetime management
15 May 2024 – From EuroPCR 2024
In this session, discover how pre-procedural assessment is used to optimize procedural outcomes, ensuring the best possible results for patients undergoing TAVI, learn the intricacies of selecting the most suitable valve for each individual patient, considering their unique anatomical and clinical factors, and engage in discussions...
TAVI in TAVI - LIVE case
14 May 2024 – From EuroPCR 2024
A 74-year-old male with a history of cancer, TAVI with Evolut R 34 in 2019, COPD, obesity, and RBBB presents with a symptomatic degenerated valve (regurgitation).
It was decided to implant a Sapien 3 Ultra 26, without pre-dilatation and post-dilatation, using a temporary pacing lead (due to...
Crossing the finishing line - Latest best practices and technologies for large hole arterial and venous closure
14 May 2024 – From EuroPCR 2024
Tune in to this session for insights on optimizing vascular access and closure techniques. Explore steps like thorough CT analysis, ultrasound-guided puncture, and contingency plans for alternative access methods to minimize complications. Discover a novel patch-based closure approach offering immediate hemostasis and simplified usage, addressing issues...
What is the optimal aortic valve choice in the younger patient: transcatheter or surgery?
29 Nov 2023 – From PCR London Valves 2023
Follow the discussion between Darren Mylotte, Kentaro Hayashida and Ole De Backer to better understand the concept of "young patients" and what it exactly implies, and analyze how best to bring these specific patients to the end of their still potentially long life, by choosing the...
Finishing strong - Latest best practices and technologies for large hole arterial and venous closure
21 Nov 2023 – From PCR London Valves 2023
Consult this session to grasp the current landscape of techniques for closing large holes in both arterial and venous contexts. Acquire valuable tips and tricks aimed at minimizing vascular complications, and learn about the innovative patch-based closure approach for a comprehensive understanding.
VitaFlow - The electrically enable self-expanding TAVI valve
21 Nov 2023 – From PCR London Valves 2023
This session provides insights into the unique design and advantages of VitaFlow Liberty for TAVI. It covers techniques to minimize microdislodgement during the procedure, identifies situations and patient types most suitable for VitaFlow Liberty, and reviews early clinical results associated with this technology.
Key questions in aortic valve intervention - How to navigate valve sequencing in younger patients?
21 Nov 2023 – From PCR London Valves 2023
What are the aspects to consider when treating younger patients? In this session, get both the interventional cardiologist's and the surgeon's perspective. What do we know and what do we need to know about valve sequencing and hemodynamics? What about CT planning and execution of redo-TAVI?...
Defying complexity: achieving optimal TAVI procedural outcomes in challenging anatomies with the new Evolut FX
20 Nov 2023 – From PCR London Valves 2023
Watch this session to understand factors to consider when deciding on valve selection, recognize the significance of device choice and implantation technique in redo-TAVI, and acquire insights into anticipating challenges associated with implanting a bicuspid valve, large anatomy, and a horizontal aorta.
TAVI - stroke
20 Nov 2023 – From PCR London Valves 2023
Join this session for key perspectives on stroke management and prevention in TAVI: gain a comprehensive view of the long-term outcomes in transfemoral TAVI complicated by stroke, evaluate a novel cerebral embolic protection during TAVI through the PROTEMBO C-TRIAL, learn how TAVR debris captured by CEP...
The Top Late-Breaking Trials: TRISCEND II, TRILUMINATE at 3 years, EuroSMR score, CLASP IID, OPERA-TAVI...
19 Nov 2023 – From PCR London Valves 2023
Discover the top late-breaking trials which were presented during PCR London Valves 2023:
- TRISCEND II: A randomised trial of transcatheter tricuspid valve replacement vs medical therapy
- Percutaneous edge-to-edge repair for tricuspid regurgitation: TRILUMINATE trial three-year outcomes
- Transcatheter mitral valve-in-valve vs. redo surgical replacement for degenerated bioprostheses
- Artificial intelligence derived risk...
Challenging TAVI cases
19 Nov 2023 – From PCR London Valves 2023
This PCR London Valves 2023 session aims to analyse some of the complex aspects of TAVI by looking at challenging clinical and anatomical scenarios to enable you to learn how to manage potential complications by learning about innovative strategies and exploring different approaches.
Cerebral embolic protection during TAVI: evidence meets practice
11 Nov 2023
Watch the replay of this webinar with D. Mylotte, C. Cook and R. Kharbanda to know more about the incidence and impact of TAVI associated stroke and much more!
Transcatheter bicuspid valve replacement: LIVE Case from Institut Cardiovasculaire Paris Sud, Massy - France
18 May 2023 – From EuroPCR 2023
Discover tips for TAVI and analyse CT findings to optimise procedural outcomes in bicuspid anatomy.
Selecting the right first valve to secure lifetime management
17 May 2023 – From EuroPCR 2023
The treatment of young and less at-risk patients clearly shows that their age, life expectancy and risk factors are essential parameters to be taken into account in the choice of TAVI and therefore it is essential to think about future coronary access after TAVI. Watch the...
Cutting-edge technologies: clinical updates on TES, BRS, TAVR and LAA closure
17 May 2023 – From EuroPCR 2023
Watch this session to find out more about the three-year outcomes of the FUTURE-II Trial, the TARGET clinical trial roadmap, the TARGET IV NA Trial update, the twelve-month outcomes of the SAVE PROTECT Trial, and the quantitative aortographic assessment of regurgitation in patients treated with VitaFlow.
EuroPCR 2023 Hotlines / Late-Breaking Trials: TAVI
16 May 2023 – From EuroPCR 2023
Discover the conclusions of various studies and registries about TAVI: 5-year outcomes with the ACURATE neo2 valve: the Neo AS CE-mark study; TAVR in patients with cardiogenic shock which evaluated outcomes of consecutive TAVRs in patients with CS using contemporary SAPIEN 3 and SAPIEN 3 ultra...
