3340 results

The CLEAR SYNERGY (OASIS 9) Trial: A 2x2 factorial randomized controlled trial of colchicine versus placebo and spironolactone versus placebo in patients with myocardial infarction

18 Nov 2024

Mirvat Alasnag provides her take on the CLEAR SYNERGY trial presented by Sanjit S Jolly at AHA 2024 in Chicago.

Author

Mirvat Alasnag

TRILUMINATE pivotal: A landmark randomized clinical trial of transcatheter tricuspid valve edge-to-edge repair for tricuspid regurgitation

04 Mar 2023

Jonathan Curio and Alex Sticchi provide their take on this clinical trial which was presented by Paul Sorajja at the American College of Cardiology Scientific Session (ACC.23/WCC).

Author

Alessandro Sticchi

Author

Jonathan Curio

Long-term beta-blocker treatment after acute myocardial infarction and preserved left ventricular ejection fraction: The REDUCE-AMI Trial

07 Apr 2024

REDUCE-AMI is a multicentre, registry-based, prospective open-label parallel-group randomised clinical trial evaluating the benefit of beta-blocker treatment in patients with acute MI and an ejection fraction >50% treated with a contemporary reperfusion strategy.

Nicola Ryan and Ali Nazmi Calik provide their take on the results which were presented...

Author

Nicola Ryan

Author

Ali Nazmi Calik

Simultaneous high-risk PCI and TAVI with hemodynamic support: a stepwise approach using Impella CP SmartAssist

26 Jun 2025

What’s the safest approach when surgical options are off the table? This real-life case shows how complex coronary revascularsation and TAVI were performed in a single session, supported by Impella.

Explore the rationale behind the sequence, the device choices, and the outcome in a high-risk patient with...

Percutaneous transseptal transcatheter mitral valve replacement using a dedicated balloon-expandable valve: 1-year outcomes from the ENCIRCLE trial using the SAPIEN M3

27 Oct 2025

Jonathan Curio provides his take on the ENCIRCLE Trial presented by David Daniels at TCT 2025 in San Francisco.

Author

Jonathan Curio

iFR versus angiography-guided CABG: 3-year results of the iCABG randomised trial

31 Oct 2025

Alex Sticchi provides his take on the iCABG trial presented by Rasa Ordiene at TCT 2025, in San Francisco.

Author

Alessandro Sticchi

TAILORED-CHIP: Tailored antiplatelet therapy for complex high-risk PCI

29 Aug 2025

Nicola Ryan provides her take on the results of TAILORED-CHIP presented by Duk-Woo Park at the ESC Congress 2025 in Madrid.

Author

Nicola Ryan

TACSI: Dual or single antiplatelet therapy after CABG in patients with acute coronary syndrome

03 Sep 2025

Aaysha Cader provides her take on TACSI presented by Anders Jeppsson at ESC Congress 2025 in Madrid.

Author

Aaysha Cader

Evidence base: A description of the key, so far published, studies in the space of drug coated balloons

23 Jan 2025

Authored by Hector Garcia-Garcia and Jorge Sanz-Sanchez, this article examines pivotal randomized clinical trials on drug-coated balloons in coronary artery disease. It highlights their role in managing in-stent restenosis, de novo small vessel lesions, and large vessel lesions while exploring future directions through ongoing trials.

Author

Hector Garcia-Garcia

Author

Jorge Sanz-Sanchez

Transcatheter edge-to-edge repair in patients with severe mitral regurgitation and cardiogenic shock: Insights from the TVT Registry

17 Sep 2022

Mirvat Alasnag provides her take on the TEER Shock study which was presented at TCT 2022 by Mohamad A. Alkhouli.

Author

Mirvat Alasnag

Drug-coated balloon (DCB) technology: A pioneer’s view of the historical evolution and future directions

08 Jan 2025

In this article, Bruno Scheller explores advances in local drug delivery, from drug-coated balloons to novel antiproliferative agents. These innovations aim to reduce restenosis, minimize permanent implants, and pave the way for patient-specific coronary artery disease treatments.

Author

Bruno Scheller

Future directions of drug-coated balloon angioplasty

06 Feb 2025

Fernando Alfonso and Javier Cuesta discuss the growing role of drug-coated balloons as an alternative to stents in percutaneous coronary interventions. Highlighting advantages like reduced in-stent restenosis, they emphasize the need for robust clinical studies to refine DCB use.

Author

Fernando Alfonso

Author

Javier Cuesta

Implantation of the Portico With FlexNav TAVI System in a patient with aortic stenosis, severe renal impairment, and diffuse iliac atherosclerosis

12 May 2020

Real-world case report illustrating the benefits of the Portico with FlexNav TAVI system.

How to choose a snare and create a snare to enhance device trackability in structural interventions

19 Dec 2023

Transcatheter structural procedures are dramatically increasing in daily practice. Approaching hostile cardiac anatomy may increase the risk of device dislodgment and/or malposition. In such situations, the use of a snare catheter is pivotal to enhance device trackability.

Author

Andrea Buono

Author

Damiano Regazzoli

Author

Diego Maffeo

Author

Gabriele Gasparini

Percutaneous coronary intervention of native coronary artery versus saphenous vein graft in patients with prior coronary artery bypass graft surgery (PROCTOR)

03 Nov 2025

Kalaivani Mahadevan and Trisha Singh provide their take on the PROCTOR study presented by Ruben de Winter at TCT 2025, in San Francisco.

Author

Kalaivani Mahadevan

Author

Trish Singh

OPTION-STEMI: Immediate versus staged complete revascularisation during index admission in patients with STEMI and multivessel disease

02 Sep 2025

Mirvat Alasnag provides her take on OPTION-STEMI, presented by Youngkeun Ahn at ESC Congress 2025 in Madrid.

Author

Mirvat Alasnag

Comparison of a precision care strategy with usual testing to guide management of stable patients with suspected CAD: the PRECISE randomized trial

09 Nov 2022

Alex Sticchi provides his take on PRECISE, which was presented during AHA 2022 in Chicago.

Author

Alessandro Sticchi

Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes: The multicenter, randomized, blinded, IVUS-ACS Trial

09 Apr 2024

Marco Spagnolo and Daniele Giacoppo report the main results of the IVUS-ACS trial presented by Shao-Liang Chen, from the Nanjing First Hospital, Nanjing Medical University, Nanjing, in a Featured Clinical Research session at ACC.24 in Atlanta and simultaneously published in The Lancet.(1)

Author

Daniele Giacoppo

Author

Marco Spagnolo

ILUMIEN IV: OPTIMAL PCI - Optical Coherence Tomography Guided Coronary Stent Implantation Compared with Angiography: A Multicenter Randomized Trial in Percutaneous Coronary Intervention

29 Aug 2023

Claudio Laudani and Daniele Giacoppo report the main results of the ILUMIEN IV trial presented by Ziad Ali, from the St. Francis Hospital, Roslyn, and Clinical Trials Center, Cardiovascular Research Foundation, New York, in a Hot Line session at the European Society of Cardiology congress 2023...

Author

Claudio Laudani

Author

Daniele Giacoppo

NEO-MINDSET: Early withdrawal of aspirin after percutaneous coronary intervention for acute coronary syndrome

02 Sep 2025

Daniele Giacoppo reports and provides his perspective on the main results of the ambitious NEOMINDSET trial, presented by Pedro Lemos from the Hospital Israelita Albert Einstein, São Paulo, Brazil, during a Late Breaking Trials session at the ESC Congress 2025 in Madrid, and simultaneously published in the New...

Author

Daniele Giacoppo