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Featured research - TAVI: procedural optimization

17 Nov 2025 – From PCR London Valves 2025

Delve into comprehensive analyses of TAVI procedural outcomes and innovations in this session. Topics include the impact of intercoronary angles on coronary overlap with Evolut valves, mechanisms behind superior outcomes with the latest balloon-expandable valves, and predictive modeling of hemodynamics using physics-enhanced digital twins. Additionally, sex-specific...

Featured research - TAVI: procedural optimization

TAVI: high coronary risk - Part 2

17 Nov 2025 – From PCR London Valves 2025

This session addresses the challenges and solutions related to high coronary risk in TAVI procedures. Topics include advanced coronary protection strategies, innovative approaches to complex valve-in-valve interventions, the benefits of balloon-assisted techniques, management of right coronary cusp obstruction through UNICORN technology, and prevention of sinus sequestration...

TAVI: complex vascular access - Part 2

17 Nov 2025 – From PCR London Valves 2025

Focus on complex vascular access challenges in TAVI with this session covering strategies such as the pave and crack technique for inaccessible vessels, management of bicuspid aortic stenosis with hostile access and horizontal aorta, complex single transfemoral access procedures, and combined interventions including left atrial appendage...

Paravalvular leaks and VSD percutaneous closure - Recorded cases

17 Nov 2025 – From PCR London Valves 2025

Recorded case 1: A 56-year-old female with a prior mechanical mitral valve replacement (Star GK, 2018), permanent AF, and normal LV function presented with recurrent HF admissions due to paravalvular leaks. She was treated with implantation of multiple plugs via a transseptal approach using a Destination...

Paravalvular leaks and VSD percutaneous closure - Recorded cases

Tricuspid valve interventions in complex scenarios - Part 2

17 Nov 2025 – From PCR London Valves 2025

This session delves into transcatheter interventions for the tricuspid valve in complex clinical scenarios. It covers techniques for native annular reduction via TEER, management of lead-related regurgitation, challenging cases of torrential regurgitation with device detachment, and innovative methods facilitating valve-in-ring implantation, enhancing procedural efficacy in tricuspid...

Cardiogenic shock: transcatheter solutions

17 Nov 2025 – From PCR London Valves 2025

This session focuses on transcatheter solutions for cardiogenic shock, highlighting rescue therapies such as mitral clip intervention in hypertrophic obstructive cardiomyopathy, valve-in-valve TAVI during CPR, and sequential mechanical circulatory support. It presents complex clinical cases illustrating stepwise approaches combining mechanical support and percutaneous valve repair to...

Leaflet modification techniques: latest acronyms, concepts and best practice

17 Nov 2025 – From PCR London Valves 2025

Gain comprehensive insights into leaflet modification techniques with a focus on the latest acronyms, concepts, and best practices. This session covers step-by-step approaches to transcatheter electrosurgical leaflet modification, including BASILICA, SHORTCUT, and UNICORN, alongside troubleshooting strategies and the innovative SURPLUS surgical technique.

Leaflet modification techniques: latest acronyms, concepts and best practice

EuroPCR 2026 Closing Ceremony

22 May 2026 – From EuroPCR 2026

The EuroPCR 2026 Closing Ceremony marks the conclusion of this premier cardiology event, celebrating the latest advances and achievements in interventional cardiology. It offers an opportunity to reflect on the educational sessions, network with peers, and recognize outstanding contributions to the field.

EuroPCR 2026 Closing Ceremony

SWISS-APERO: a randomized trial of the amulet versus watchman FLX devices for left atrial appendage closure

04 Nov 2021

The SWISS-APERO is a prospective, investigator-initiated, randomized, multi-center, and clinical trial designed to compare the Amulet and Watchman (2.5 and FLX) devices in a head-to-head fashion.

Francesco Costa

Author

Francesco Costa
SWISS-APERO: a randomized trial of the amulet versus watchman FLX devices for left atrial appendage closure

Coronary arteries

30 Oct 2017

The coronary arteries arise from the aortic sinuses. Read more...

 Coronary arteries

CHOICE-CLOSURE: a randomized trial of plug-based versus suture-based large-bore vascular closure

06 Nov 2021

TCT 2021: Radoslaw Parma reviews the CHOICE-CLOSURE multicentre, randomized, controlled, open-label clinical trial presented by Mohamed Abdel-Wahab. The study compared outcomes of percutaneous femoral artery closure using a plug-based and a primary suture-based strategy in patients undergoing TAVI.

Author

Radoslaw Parma
CHOICE-CLOSURE: a randomized trial of plug-based versus suture-based large-bore vascular closure

The PASCAL IID Registry: A prospective registry for transcatheter edge-to-edge repair in prohibitive risk patients with degenerative mitral regurgitation and complex mitral valve anatomy

17 Sep 2022

Alex Sticchi provides his take on the PASCAL IID Registry and an initial comparison with the CLASP IID. The trial was presented by Jörg Hausleiter during TCT Congress 2022.

Alessandro Sticchi

Author

Alessandro Sticchi
The PASCAL IID Registry: A Prospective Registry for Transcatheter Edge-to-Edge Repair in Prohibitive Risk Patients With Degenerative MR and Complex Mitral Valve Anatomy

Meril presents successful LANDMARK RCT one-year results at prestigious EuroPCR 2025

21 May 2025

Best of #AHA21 Scientific Sessions: coronary and valvular heart disease trials

14 Nov 2021

Vijay Kunadian provides summaries of study designs and findings in Interventional Cardiology released at the 2021 virtual edition of the American Heart Association Congress. View an infographic of the AVATAR late-breaking trial by Ali Nazmi Calik.

Vijay Kunadian

Author

Vijay Kunadian
Best of #AHA21 Scientific sessions

A large-scale, randomized trial of orbital atherectomy vs. conventional balloon angioplasty in severely calcified coronary arteries prior to DES implantation (ECLIPSE)

30 Oct 2024

Nicola Ryan provides her take on the ECLIPSE trial presented by Ajay J. Kirtane at TCT 2024 in Washington.

Nicola Ryan

Author

Nicola Ryan
A large-scale, randomized trial of orbital atherectomy vs. conventional balloon angioplasty in severely calcified coronary arteries prior to DES implantation (ECLIPSE)

Percutaneous transseptal transcatheter mitral valve replacement using a dedicated balloon-expandable valve: 1-year outcomes from the ENCIRCLE trial using the SAPIEN M3

27 Oct 2025

Jonathan Curio provides his take on the ENCIRCLE Trial presented by David Daniels at TCT 2025 in San Francisco.

Jonathan Curio

Author

Jonathan Curio
Percutaneous transseptal transcatheter mitral valve replacement using a dedicated balloon expandable valve: 1 year outcomes from the ENCIRCLE trial using the SAPIEN M3

Early intervention in patients with asymptomatic severe aortic stenosis and left ventricular myocardial fibrosis (EVOLVED)

30 Oct 2024

Ali Nazmi Calik provides his take on the EVOLVED trial presented by Marc Dweck at TCT 2024 in Washington.

Author

Ali Nazmi Calik
Early intervention in patients with asymptomatic severe aortic stenosis and left ventricular myocardial fibrosis (EVOLVED)

NOTION-3 - Percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation

01 Sep 2024

Make the most of the insights from Jacob Thomsen Loenborg’s interview with Chiara De Biase and Ali Nazmi Calik’s article to capture the key takeaways from this trial, simultaneously published in the NEJM, presented at the ESC Congress 2024 in London.

Author

Chiara De Biase
Jacob Lønborg

Author

Jacob Lønborg

Author

Ali Nazmi Calik
NOTION 3
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