What are the challenges for TAVI in bicuspid disease?

PCR Perspectives

Summary

Raj Makkar and Didier Tchétché address the complexities of bicuspid aortic valve disease, defining ideal candidates for TAVI or replacement and reviewing the NOTION-2 trial, which randomized younger, low-risk patients—including a significant number with bicuspid valves—to TAVI versus surgery. They highlight the importance of embolic protection devices, and share insights from the SHORT-CUT pivotal trial on leaflet modification therapy, suggesting its potential future role. Lastly, they consider the need for comparative studies of devices for bicuspid aortic valves, akin to the SMART trial.

This interview was filmed at EuroPCR 2024: see more videos here.