Controlled trial of high-risk coronary intervention with percutaneous left ventricular unloading (CHIP-BCIS3)

Reported from ACC.26

Aaysha Cader interviews Divaka Perera on the CHIP-BCIS3 randomised trial, which evaluated whether elective left ventricular (LV) unloading during high-risk PCI improves outcomes in patients with severe LV dysfunction, extensive coronary disease, and complex procedures, as presented at ACC.26 in New Orleans.

The results of CHIP-BCIS 3 showed that in elective high-risk PCI, an LV unloading strategy with a microaxial flow pump did not reduce MACE compared to standard of care. Overall, the study concludes that routine elective LV unloading in this population does not improve outcomes and may be harmful, highlighting the importance of procedural strategy (e.g., staged PCI) over systematic device use.