PCRonline @ ACC 2026 Scientific Sessions

The Interventional Cardiology perspective!

Live updates on a selection of major Late Breaking Clinical Trials of interest in interventional cardiology presented at the American College of Cardiology 2026 Scientific Sessions #ACC26

Mirvat Alasnag, Elad Asher, Luigi Biasco, Aaysha Cader, Ali Nazmi Calik, Jonathan Curio, Chiara De Biase, Daniele Giacoppo, Kalaivani Mahadevan, Yohei Ohno, Nicola Ryan and Alex Sticchi will provide their take on what's new and what's hot in the field of interventional cardiology at ACC.26 and offer you condensed take-home messages, live from the congress. Discover the topics covered below!

Late-breaking Clinical Trials and Science to be covered:

Outcomes in patients with atrial fibrillation randomized to receive left atrial appendage closure or oral anticoagulation: Primary results of the CHAMPION-AF clinical trial
Primary left ventricular unloading in anterior ST-Segment Elevation Myocardial Infarction (STEMI) without cardiogenic shock: Results from the STEMI-Door to Unload randomized clinical trial
A prospective multicenter registry to define coronary vasomotor disorders in ischemia with nonobstructive coronary arteries: Primary results of DISCOVER INOCA
Coronary optical coherence tomography and cardiac magnetic resonance imaging to determine sex differences in underlying causes of myocardial infarction with no obstructive coronary arteries
10-year follow-up of clopidogrel vs aspirin monotherapy in stable coronary artery disease after percutaneous coronary intervention with drug-eluting stent (HOST-EXAM)
Controlled trial of high-risk coronary intervention with percutaneous left ventricular unloading (CHIP-BCIS3)
A large-scale, global randomized trial of coronary physiology derived from conventional angiography compared with an invasive pressure wire-based approach to guide percutaneous coronary intervention (ALL-RISE)
A randomized, placebo-controlled trial of chronic total occlusion percutaneous coronary intervention in stable angina - ORBITA-CTO trial
Fractional flow reserve or 3d-quantitative coronary angiography-based vessel-ffr guided revascularisation – The FAST III Trial
Redo-surgery versus transcatheter valve-in-valve for mitral bioprosthetic dysfunction: The SURVIV trial
Transcatheter aortic valve implantation without routine percutaneous coronary intervention: PRO-TAVI randomized controlled trial
Protect the head to head trial: Randomized comparison of emboliner embolic protection catheter vs. sentinel cerebral protection system during transcatheter aortic valve replacement
Two-year outcomes after transcatheter tricuspid repair without cross-over in the randomized Tri-fr trial
Two-year outcomes of transcatheter tricuspid valve replacement for severe tricuspid regurgitation: The TRISCEND II randomized trial
Intravascular ultrasound guidance for complex high-risk indicated procedures – The IVUS Chip trial
Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in unprotected left main coronary artery disease – The OPTIMAL trial
Ivus or angiography guidance for PCI in complex coronary bifurcation lesions (DKCRUSH VIII)