Christopher Cook

Christopher Cook

Interventional cardiologist / Cardiologist
The Essex Cardiothoracic Centre - Basildon, United Kingdom

Member of the Editorial Team, PCRonline Editorial Board

Declaration of interest

FunctionCompany
HonorariumPhillips Healthcare

Latest contributions

Latest learnings on the treatment of asymptomatic severe aortic stenosis from the EARLY TAVR

22 May 2025 – From EuroPCR 2025

At EuroPCR 2025, Christopher Cook, Philippe Genereux, and Victoria Delgado discuss key results from the EARLY TAVR study.

In asymptomatic patients with severe aortic stenosis, early intervention was associated with significantly less cardiac damage at 2 years, compared to a surveillance strategy that led to extensive damage...

Latest learnings on the treatment of asymptomatic severe aortic stenosis from the EARLY TAVR

Structural and Valvular Interventions: EuroPCR 2025 highlights

22 May 2025 – From EuroPCR 2025

Christopher Cook, Nicolas Dumonteil, and Bernard Prendergast share their top EuroPCR 2025 highlights in structural heart interventions. Challenging cases like re-do TAVI, coronary re-access difficulties, and leaflet modification took center stage in case-based and LIVE sessions. Cutting-edge research was featured too, including a meta-analysis combining the...

Structural: EuroPCR 2025 highlights

Complex PCI in a TAVI patient - LIVE case

20 May 2025 – From EuroPCR 2025

An 84-year-old patient with a history of ischemic stroke in 2017, hypertension, diabetes, dyslipidemia, and a preserved LV function (63 %) presented with a severe symptomatic aortic stenosis. The coronary angiography revealed a severe and calcified stenosis of the distal left main.
Operators implanted an Edwards Sapien...

Complex PCI in a TAVI patient - LIVE case

TAVI in patients with a small annulus

20 May 2025 – From EuroPCR 2025

Address the unique challenges of transcatheter aortic valve implantation (TAVI) in patients with small aortic annuli. This session discusses comparative outcomes of balloon-expandable versus self-expandable valves, size prediction methodologies, and management of paravalvular regurgitation in low-flow, low-gradient aortic stenosis cases.

TAVI in patients with a small annulus

Clinical impact of TAVI frame under-expansion and optimisation strategies

07 Mar 2025

Watch this replay with C. Cook, M. Grygier, A. Khokhar and W-K. Kim to learn about the clinical importance of TAVI frame under-expansion, and so much more!

Heart to Heart Conversations podcasts – expert insights in interventional cardiology, anytime, anywhere

06 Feb 2025

Stay ahead in interventional cardiology with Heart-to-heart podcasts, the audio companion to our acclaimed webinar series.

Focus on Fundamentals in TAVI and mitral - PCR London Valves 2024

Christopher Cook interviews Nicole Karam about the Fundamentals Course, a key component of the PCR London Valves programme that continues to expand each year. Designed for beginners in TAVI or mitral interventions, the course guides participants through every step of a procedure, starting with the basics...

Focus on Fundamentals in TAVI and mitral - PCR London Valves 2024

How to improve TAVI durability - LIVE case

26 Nov 2024 – From PCR London Valves 2024

Explore two fascinating cases tackling severe aortic valve challenges with innovative approaches:

  • LIVE Case: An 84-year-old woman with a history of breast cancer and TAVI (Evolut Pro 29) in 2016, presenting with symptomatic severe TAVI stenosis. CT revealed a true ID of 19 mm. The team implanted...
TAVI durability and treatment options

Tricuspid valve disease: PCR London Valves 2024 highlights

26 Nov 2024 – From PCR London Valves 2024

Nicolo Piazza and Fabien Praz join Christopher Cook to highlight the key takeaways from the latest presentations on the tricuspid valve.They evoke the new research and scientific evidence that will have an impact on clinical practice, the rapidly evolving technical innovations and the challenges facing tricuspid...

Tricuspid valve disease: PCR London Valves 2024 highlights

Aortic valve: PCR London Valves 2024 highlights

26 Nov 2024 – From PCR London Valves 2024

Chris Cook interviews Hélène Eltchaninoff and Bernard Prendergast to discuss the highlights of PCR London Valves 2024, focusing on aortic valve disease. They explore how groundbreaking research, including the EARLY TAVR and COMPARE TAVI trials, is shaping and transforming clinical practice.

This interview was filmed at PCR...

Aortic valve: PCR London Valves 2024 highlights

From index procedure to re-valving with a novel self-expanding valve

25 Nov 2024 – From PCR London Valves 2024

Watch this simulation-based symposium to explore the value of the Index Procedure in achieving optimal outcomes during the initial implant, crucial for preventing paravalvular leak, pacemaker dependency, and ensuring precise commissural alignment for coronary access. Discover how the ACURATE neo2/PRIME offers excellent coronary access with its...

From index procedure to re-valving with a novel self-expanding valve

How to establish a mitral TEER programme

24 Nov 2024 – From PCR London Valves 2024

Ready to start your journey toward establishing a mitral TEER programme? This video covers everything you need to know—from understanding the contemporary role of TEER in managing mitral regurgitation to building a Heart Team and referral network.

Learn how to find your first cases, select the right...

How to establish a mitral TEER programme

TAVI and coronary artery disease

24 Nov 2024 – From PCR London Valves 2024

How does coronary artery disease shape outcomes in TAVI patients, and when should revascularization come into play? This video explores these critical questions, offering a deep dive into the latest evidence and strategies for managing combined aortic stenosis and coronary artery disease.

From understanding revascularization timing to...

TAVI and coronary artery disease

TAVI - Step by step

16 May 2024 – From EuroPCR 2024

This interactive session provides a step-by-step guide on performing minimalist TAVI procedures. Attendees will learn how to optimize TAVI for speed and safety, with a deep dive on the safest techniques for large-bore arterial access and vessel closure. Key topics include femoral access, fluoroscopic projections, crossing...

TAVI - Step by step

Interventions for valvular disease: Highlights of EuroPCR 2024

16 May 2024 – From EuroPCR 2024

Christopher Cook hosts Nicolas Dumonteil and Bernard Prendergast as they share EuroPCR 2024 insights on valve disease interventions. Nicolas Dumonteil highlights record-breaking abstracts and cases, demonstrating expertise in TAVI, mitral, and tricuspid procedures. Bernard Prendergast emphasizes LIVE cases, especially in complex TAVI scenarios, reflecting everyday practice. Both stress...

Interventions for valvular disease

NOTION-2: first TAVI vs. SAVR randomised trial in younger low-risk patients with severe tricuspid or bicuspid aortic valve stenosis

15 May 2024 – From EuroPCR 2024

Christopher Cook interviews Ole de Backer about this study he presented at EuroPCR 2024: It provides further data concerning the 1-year outcome of younger AS patients with tricuspid valve anatomy treated with TAVI compared to SAVR. TAVI and SAVR showed similar rates of the primary endpoint...

NOTION-2: first TAVI vs. SAVR randomised trial in younger low-risk patients with severe tricuspid or bicuspid aortic valve stenosis

First report of an IDE pivotal study of a dedicated splitting device during TAVR

15 May 2024 – From EuroPCR 2024

Watch this interview in which Christopher Cook hosts Martin Leon to discuss pivotal study data on the ShortCut dedicated leaflet splitting device. They revisit the unmet clinical need for leaflet splitting during TAVR: transcatheter valve failures, noting that transcatheter valve failures could surpass surgical bioprosthetic valve failures...

First report of an IDE pivotal study of a dedicated splitting device during TAVR

The LANDMARK trial: early outcomes of a randomised non-inferiority trial comparing TAVI devices

15 May 2024 – From EuroPCR 2024

In this video, Christopher Cook interviews Patrick Serruys about the late-breaking clinical trial data from the LANDMARK RCT. Patrick Serruys begins by explaining the LANDMARK trial, which compares TAVI devices, and emphasizes the complexity of applying VARC-3 criteria. He highlights that the 30-day outcomes confirm the...

The LANDMARK trial: early outcomes of a randomised non-inferiority trial comparing TAVI devices

PCR Teaching Assessment Board: innovation in medical education via peer review feedback

15 May 2024 – From EuroPCR 2024

Victoria Jenkins, William Wijns, and Christopher Cook introduce the Teaching Assessment Board, similar to the peer review process in scientific literature. This group provides structured feedback to teachers and participants, inspired by manuscript evaluation methods to enhance educational quality. The aim is to help faculty improve...

PCR Teaching Assessment Board: innovation in medical education via peer review feedback

Strengthening cardiovascular care resilience for healthier hearts: the RESIL-Card project

15 May 2024 – From EuroPCR 2024

In this interview at EuroPCR 2024, William Wijns, Niek Klazinga, and Christopher Cook discuss the RESIL-Card initiative, which emerged from the disruption to cardiovascular care during COVID-19. The initiative aims to use this experience to develop a readiness test for future crises. Extensive data has been collected,...

Strengthening cardiovascular care resilience for healthier hearts: the RESIL-Card project

AID-ANGIO study: performing ad hoc microvascular assessment during diagnostic coronary angiography

14 May 2024 – From EuroPCR 2024

Christopher Cook interviews Javier Escaned to unravel the AID-ANGIO study, probing its purpose, methodology, and key outcomes. This study aimed to showcase the viability, safety, and diagnostic benefits of performing invasive functional testing ad hoc in managing patients with chronic coronary syndromes.

This interview was filmed at...

AID-ANGIO study: performing ad hoc microvascular assessment during diagnostic coronary angiography

Focus on aortic valves

22 Nov 2023 – From PCR London Valves 2023

Simon Redwood and Christopher Cook cover the top three highlights of the aortic track at #PCRLV 2023:

  • LIVE and recorded cases showcasing procedures from simple to highly complex.
  • Engaging discussions on TAV in TAV procedures to enhance our ability to effectively treat patients.
  • Long-term data and late trial results...
Highlights from PCR London Valves 2023 - Focus on aortic valves

Focus on mitral valves

22 Nov 2023 – From PCR London Valves 2023

Didier Tchétché and Christopher Cook have selected three key highlights from the mitral learning at #PCRLV 2023:

  • The celebration of the 20th anniversary of the first TEER, marked by an emotional moment and illustrated with a challenging LIVE case of mitral TEER,
  • Imaging at the core of this...
Highlights from PCR London Valves 2023 - Focus on mitral valves

TAVI unleashed: optimisation of immediate and long-term outcomes

20 Nov 2023 – From PCR London Valves 2023

Consult this session if you want to gain insights into the effects of paravalvular leak, conduction disturbances, stroke, and permanent pacemaker issues following transcatheter aortic valve implantation. The discussion also delves into the design of transcatheter heart valves and its implications for selecting the initial valve...

TAVI unleashed: optimisation of immediate and long-term outcomes

TAVI: From simple to complex - LIVE case

20 Nov 2023 – From PCR London Valves 2023

This session explores two clinical cases, providing valuable insights into the essential components of a straightforward and efficient TAVI procedure. Find out more about the application of innovative devices to broaden the scope of aortic valve intervention, facilitating their integration into Heart Team discussions and daily...

TAVI - from simple to complex - LIVE case

Cerebral embolic protection during TAVI: evidence meets practice

11 Nov 2023

Watch the replay of this webinar with D. Mylotte, C. Cook and R. Kharbanda to know more about the incidence and impact of TAVI associated stroke and much more!

EuroPCR 2023 Highlights: Interventions for Valvular Disease

20 May 2023 – From EuroPCR 2023

Nicolas Dumonteil and Bernard Prendergast join Christopher Cook in the PCR recording studio to talk about their personal highlights from another fantastic edition of EuroPCR. From the simulation programme - a key activity of PCR Courses - to the traditional learning sessions by and for the...

EuroPCR 2023 Highlights on interventions for valvular disease

Transcatheter bicuspid valve replacement: LIVE Case from Institut Cardiovasculaire Paris Sud, Massy - France

18 May 2023 – From EuroPCR 2023

Discover tips for TAVI and analyse CT findings to optimise procedural outcomes in bicuspid anatomy.

Transcatheter bicuspid valve replacement: LIVE Case from Institut Cardiovasculaire Paris Sud, Massy - France

Artificial intelligence: current applications in coronary image analysis in its potential in treatment planning

18 May 2023 – From EuroPCR 2023

What should cardiologists be aware of regarding artificial intelligence? How will artificial intelligence impact interventional cardiology? If you share these questions, absolutely watch this presentation.

Artificial intelligence: current applications in coronary image analysis in its potential in treatment planning

How achieving optimal index procedural outcomes can positively influence future TAVI treatment options

23 Feb 2023

Watch the replay of this webinar to understand the impact of procedural outcomes on future TAVI treatment options, and much more!