Jonathan Byrne

Jonathan Byrne

Interventional cardiologist / Cardiologist
King's College Hospital NHS Foundation Trust - London, United Kingdom

Latest contributions

Paravalvular leak closure: challenges and percutaneous solutions

21 May 2025 – From EuroPCR 2025

This session addresses the challenges and percutaneous techniques for paravalvular leak closure following valve replacement. Through complex case studies, it explores managing unexpected anatomical defects, dealing with failed closure attempts, and strategies in malpositioned valves, providing practical guidance for successful intervention in difficult scenarios.

Paravalvular leak closure: challenges and percutaneous solutions

Cathlab harmony: building high-performance teams

21 May 2025 – From EuroPCR 2025

Discover strategies to build and maintain high-performance teams in the cathlab environment. This session outlines how to foster a collaborative culture, address toxic behaviors, and effectively train and integrate team members to enhance teamwork and procedural success in cardiovascular interventions.

Cathlab harmony: building high-performance teams

Pioneering innovation in the treatment of mitral and tricuspid regurgitation

20 May 2025 – From EuroPCR 2025

This interventional session explores therapeutic strategies for mitral and tricuspid regurgitation, focusing on the clinical decision-making process between repair and replacement. Through two clinical cases, a 78-year-old male patient with severe degenerative mitral regurgitation and an 88-year-old female patient with atrial functional mitral regurgitation, experts review available...

Pioneering innovation in the treatment of mitral and tricuspid regurgitation

Advanced imaging in tricuspid TEER - LIVE case

26 Nov 2024 – From PCR London Valves 2024

Watch a LIVE case followed by a recorded case on how to use imaging in tricuspid TEER:

  • A 64-year-old male with a history of CABG and COPD, ICD implantation (2013) mitraclip (2018) and poor LV function (25%), presented a torrential functional tricuspid regurgitation. The operators implanted 2...
Advanced imaging in tricuspid TEER - LIVE case

Featured cases - Non-transfemoral TAVI access

26 Nov 2024 – From PCR London Valves 2024

Delve into this session showcasing a range of non-transfemoral TAVI access techniques from PCR London Valves 2024. Discover alternative approaches such as transiliac, transsubclavian, and transcaval access, employed to overcome complex anatomical challenges. Learn how to navigate tortuous vasculature, snare-assisted TAVR, and transform access when traditional...

Featured cases - Non-transfemoral TAVI access

Insights from real-world and post-market evidence on Tricuspid TEER

26 Nov 2024 – From PCR London Valves 2024

In this video, Mirjam Wild, Tobias Kister, and Jonathan Byrne discuss real-world evidence from transcatheter edge-to-edge repair, focusing on the TriCLASP and PACE registries. These studies evaluate the PASCAL Precision system for tricuspid regurgitation and its impact on clinical practice.

This interview was filmed at PCR London...

Insights from real-world and post-market evidence on Tricuspid TEER

Minimally invasive mitral valve surgery - Staying ahead of the game

25 Nov 2024 – From PCR London Valves 2024

Ready to stay ahead in minimally invasive mitral valve surgery? Don't miss this video!

You’ll explore advanced surgical treatment options for valve diseases, learn how the pathophysiology of mitral and tricuspid regurgitation impacts surgical repair techniques, weigh the pros and cons of interventional and surgical approaches for...

Minimally invasive mitral valve surgery - Staying ahead of the game

Featured cases - Paravalvular leak closure

24 Nov 2024 – From PCR London Valves 2024

Dive into a captivating session showcasing selected PCR London Valves 2024 clinical cases on paravalvular leak closure. Witness the use of a hybrid approach for aortic paravalvular leaks, the management of infective endocarditis complications, and the percutaneous treatment of complex malpositioned valves. Explore interventions to address...

Featured cases - Paravalvular leak closure

Tricuspid valve intervention - Current devices and future perspectives

24 Nov 2024 – From PCR London Valves 2024

Curious about how to tackle the challenges of tricuspid valve interventions? This video dives into the latest devices and strategies, showing you how to select the right approach for each patient.

Watch experienced practitioners treat real-world cases, from atrial functional regurgitation to large annulus gaps and complex...

Tricuspid valve intervention - Current devices and future perspectives

TEER for primary mitral regurgitation - LIVE case

15 May 2024 – From EuroPCR 2024

A 76-year-old male, with previous CABG in 2015, hypertension, diabetes, and pulmonary hypertension (WHO2), presented with severe symptomatic primary MR (P3 flail).
The operators implanted 1 MitraClip (XTW) step-by-step, from the transseptal puncture to the closure, guided by TEE echo and under general anaesthesia, via the venous...

Mitral TEER

When the pulmonary valve is the problem

14 May 2024 – From EuroPCR 2024

This session will feature a series of selected clinical case submissions from EuroPCR 2024, focusing on the management of pulmonary valve-related issues. Attendees will have the opportunity to explore various scenarios, including pulmonary balloon valvotomy in dextrocardia, transcatheter pulmonary valve implantation in dilated right ventricular outflow...

When the pulmonary valve is the problem

Mitral valve intervention in complex scenarios - Transcatheter paravalvular leak closure

21 Nov 2023 – From PCR London Valves 2023

Everything you need to know about mitral PVL and transcatheter closure is outlined in this session: clinical implications, indications for transcatheter closure, role of imaging, necessary access and equipment, and even tips for difficult anatomies.

Mitral valve intervention in complex scenarios - Transcatheter paravalvular leak closure

Contemporary surgical and transcatheter approaches for multivalve disease

21 Nov 2023 – From PCR London Valves 2023

Explore modern surgical and transcatheter strategies for addressing multivalve disease in this session:  gain in-depth knowledge about the current approaches in both surgical and transcatheter management of multivalve disease, develop a profound understanding of algorithms guiding the identification of the dominant valve lesion and shaping procedural...

Contemporary surgical and transcatheter approaches for multivalve disease

How to treat my patient with primary mitral regurgitation?

20 Nov 2023 – From PCR London Valves 2023

In this session, study the different cases of primary mitral regurgitation in detail, with diagrams, videos and even recommendations, to find out when to opt for replacement rather than repair, how to better manage transcatheter mitral replacement, and how to get to grips with endoscopic mitral...

How to treat my patient with primary mitral regurgitation?

Key questions in tricuspid valve intervention - How does the role of the right heart and pulmonary vasculature influence patient selection?

19 Nov 2023 – From PCR London Valves 2023

Explore insights from an 86-year-old female patient's case with TAVR since end-2022 who presented with permanent AF, moderate MR and TR regurgitation, and learn more about right heart catheterisation for patient selection, CT and CMR in tricuspid interventions, criteria for atrial secondary TR, and more!

How does the role of the right heart and pulmonary vasculature influence patient selection?

Valve-in-valve - LIVE case

17 May 2023 – From EuroPCR 2023

Study the case of a 76-year-old female patient with BMI 32, atrial fibrillation, diabetes, mid chronic kidney disease and history of aortic stenosis, whose Perimount Magna Ease 21 (mismatch) surgical bioprosthesis, implanted in 2016, degenerated, with preserved left ventricular function. 

An Evolut Pro 26 was implanted in...

Valve-in-valve - LIVE case

AfricaPCR 2023: Closing Ceremony

04 Mar 2023 – From AfricaPCR 2023

Beyond all the thanks that should naturally be expressed at the time of closing this new edition of AfricaPCR, this closing ceremony is also an opportunity to remind that the contents of this course remain available on our platforms and social networks, and that the appointment...

AfricaPCR 2023: Closing Ceremony

How should I treat a patient with bifurcation coronary disease - A patient's journey

04 Mar 2023 – From AfricaPCR 2023

Consider the case of a 66-year-old male patient with no previous cardiac history, but HTN for 20 years, presenting after a successfully thrombolysed inferior STEMI within the 12 hours, no other immediately obvious risk factor for IHD, good baseline functional capacity and normal bio-profile, and compare...

How should I treat a patient with bifurcation coronary disease - A patient's journey

Intervention makes a difference

04 Mar 2023 – From AfricaPCR 2023

This AfricaPCR 2023 session includes presentations of 5 cases highlighting the importance of percutaneous interventions, which often have a considerable impact on the patients who undergo them.

Intervention makes a difference

TAVI for bicuspid aortic valve - LIVE case

03 Mar 2023 – From AfricaPCR 2023

Watch how this 80-year-old man with severe, symptomatic, heavily calcified bicuspid aortic stenosis, who initially presented with NSTEMI, was treated, and learn about a simplified step-by-step TAVI procedure.

Balloon valvuloplasty was performed, followed by LAD PCI with a rotablator and stent, prior to the TAVI procedure, which...

TAVI for bicuspid aortic valve

Challenging femoral access and alternative access

03 Mar 2023 – From AfricaPCR 2023

In this session, learn about femoral artery dissection after TAVI, femoral perforation, alternative access for TAVI, and follow discussions about the safest way to perform transfemoral access, among others!

Challenging femoral access and alternative access

AfricaPCR 2023: Opening Ceremony

03 Mar 2023 – From AfricaPCR 2023

After 3 years without a physical Course, it is with great pleasure that the speakers open this new edition of AfricaPCR. They begin by recalling the values of this Course and presenting its Directors, then they unfold the programme by underlining the strong points and also...

AfricaPCR 2023: Opening Ceremony

Mitral edge-to-edge repair: challenging cases

Watch an acute papillary muscle rupture with torrential mitral regurgitation, a transcatheter mitral edge-to-edge repair in recurrent mitral regurgitation after Alfieri stitch, and several other exciting challenging cases in this PCR LV 2022 session!

Mitral edge-to-edge repair: challenging cases

Mitral edge-to-edge repair: surgical and transcatheter approaches - LIVE case

29 Nov 2022 – From PCR London Valves 2022

Learn from these 2 cases of primary mitral repair using percutaneous and surgical approaches:

  1. LIVE case - A 90-year-old male with history of LAD PCI 23 years ago and paroxysmal atrial fibrillation presents a primary mitral regurgitation (P2 prolapse) on mildly dilated LV and preserved LV function.
    The operators...
Mitral edge-to-edge repair: surgical and transcatheter approaches

Twenty years of progress - What we have achieved - LIVE case

27 Nov 2022 – From PCR London Valves 2022

  • Part 1: TAVI by axillary access (Live)
    An 80-year-old female with peripheral arterial disease presents a symptomatic severe aortic stenosis with small annulus and preserved LV function.
    The operators implant, by axillary access, an Evolut pro 26 mm, on general anaesthesia, with predilatation (Balloon 18 mm) and post-dilatation...
Twenty years of progress - What we have achieved

The Future of TAVI

19 May 2022 – From EuroPCR 2022

Consut this session if you want to appraise the originality of the TAVI concept, to learn the feasibility of minimalist procedure and fast track patient pathway and to understand the expansion of indications and the future of TAVI.

The Future of TAVI

EuroPCR 2022 Hotlines / Late-Breaking Trials in TAVI: TRANSIT-PPM, LYTEN, SCOPE 2, and more!

18 May 2022 – From EuroPCR 2022

Find out more about various studies & registries in TAVI! Balloon vs. self-expanding valves in valve-in-valve TAVI, trilogy for treatment of aortic regurgitation, management of Myocardial Revascularization in Patients with Stable Coronary Artery Disease Undergoing TAVI, SCOPE 2 subanalysis, prosthesis-patient mismatch following TAVR, and stroke complicating...

EuroPCR 2022 Hotlines / Late-Breaking Trials in TAVI: TRANSIT-PPM, LYTEN, SCOPE 2, and more!

Transcatheter mitral valve repair and replacement: optimal technique and procedural refinement

23 Nov 2021 – From PCR London Valves 2021

This PCR London Valves 2021 interactive learning session is designed to review the basics but also the more advanced and complex procedural steps of transcatheter mitral edge-to-edge repair, as this procedure requires a rigorous and standardized technique that can take time to learn.

Transcatheter mitral valve repair and replacement: optimal technique and procedural refinement

Percutaneous tricuspid valve replacement: how to perform it - Session with LIVE demonstration

19 May 2021 – From EuroPCR 2021

Watch this session if you want to learn how to select patients, to understand how to perform a percutaneous tricuspid replacement, and to gain tips and tricks.

This session was originally presented during EuroPCR 2021.

Percutaneous tricuspid valve replacement: how to perform it

Percutaneous mitral treatment: replacement

18 May 2021 – From EuroPCR 2021

Watch this session if you want to understand patient selection for percutaneous mitral treatment, to select percutaneous valve repair or replacement, and to learn tips and tricks in percutaneous valve treatment.

This session was originally presented during EuroPCR 2021.

Percutaneous mitral treatment: replacement