Jonathan Byrne
Latest contributions
How to treat aortic regurgitation
22 May 2026 – From EuroPCR 2026
Explore cutting-edge transcatheter approaches for aortic regurgitation, including first-in-human ATLAS technique, management in LVAD patients, and off-label Myval use. This session reviews clinical challenges and innovative solutions in aortic valve interventions, offering valuable insights from complex procedural experiences.
Advancing TAVI practice
21 May 2026 – From EuroPCR 2026
Advancing TAVI practice is the focus of this session, addressing antiplatelet therapy choices, novel transcatheter treatments for pure aortic regurgitation, early hemodynamic valve deterioration as a prognostic marker, prosthesis-patient mismatch in redo-TAVI, pioneering valve-in-mechanical valve interventions, and comprehensive core-lab evaluation of implantation depth and clinical outcomes.
TAVI in aortic regurgitation and large annulus
20 May 2026 – From EuroPCR 2026
Focusing on TAVI in patients with aortic regurgitation and large annulus, this session reviews clinical outcomes and advancements including aneurysm progression slowing, device regurgitation assessment by cardiac MRI, one-year results with Ken-valve, novel retrievable self-expanding valves, staging classifications, and balloon-expandable valve performance.
Align for the future with structural heart innovations - LIVE case and major trial updates
19 May 2026 – From EuroPCR 2026
Stay abreast of structural heart innovations with expert discussions on best-in-class transcatheter aortic valve implantation (TAVI) practices, including imaging, sizing, and procedural strategies. This session with LIVE case introduces the novel Myval Octapro+ transcatheter heart valve (THV), its design philosophy, and potential clinical benefits, along with...
Beyond the angiogram: contemporary management of STEMI
19 May 2026 – From EuroPCR 2026
This session provides an in-depth review of complex STEMI cases from diverse clinical settings, emphasizing optimisation of primary PCI strategies, complication management, and individualised antithrombotic therapy. Real-world cases from Albania, Macedonia, and Slovakia illustrate diagnostic challenges and therapeutic decision-making to improve patient outcomes.
Paravalvular leaks and VSD percutaneous closure - Recorded cases
17 Nov 2025 – From PCR London Valves 2025
Recorded case 1: A 56-year-old female with a prior mechanical mitral valve replacement (Star GK, 2018), permanent AF, and normal LV function presented with recurrent HF admissions due to paravalvular leaks. She was treated with implantation of multiple plugs via a transseptal approach using a Destination...
Complications and bailout strategies in transcatheter mitral edge-to-edge repair
16 Nov 2025 – From PCR London Valves 2025
This session addresses common complications encountered during transcatheter mitral edge-to-edge repair (TEER) and outlines device-specific bailout strategies. Expert operators share essential tips and tricks to recognize and manage these challenges effectively, ensuring optimized procedural safety and success.
Cathlab harmony: building high-performance teams
21 May 2025 – From EuroPCR 2025
Discover strategies to build and maintain high-performance teams in the cathlab environment. This session outlines how to foster a collaborative culture, address toxic behaviors, and effectively train and integrate team members to enhance teamwork and procedural success in cardiovascular interventions.
Paravalvular leak closure: challenges and percutaneous solutions
21 May 2025 – From EuroPCR 2025
This session addresses the challenges and percutaneous techniques for paravalvular leak closure following valve replacement. Through complex case studies, it explores managing unexpected anatomical defects, dealing with failed closure attempts, and strategies in malpositioned valves, providing practical guidance for successful intervention in difficult scenarios.
Pioneering innovation in the treatment of mitral and tricuspid regurgitation
20 May 2025 – From EuroPCR 2025
This interventional session explores therapeutic strategies for mitral and tricuspid regurgitation, focusing on the clinical decision-making process between repair and replacement. Through two clinical cases, a 78-year-old male patient with severe degenerative mitral regurgitation and an 88-year-old female patient with atrial functional mitral regurgitation, experts review available...
Advanced imaging in tricuspid TEER - LIVE case
26 Nov 2024 – From PCR London Valves 2024
Watch a LIVE case followed by a recorded case on how to use imaging in tricuspid TEER:
- A 64-year-old male with a history of CABG and COPD, ICD implantation (2013) mitraclip (2018) and poor LV function (25%), presented a torrential functional tricuspid regurgitation. The operators implanted 2...
Featured cases - Non-transfemoral TAVI access
26 Nov 2024 – From PCR London Valves 2024
Delve into this session showcasing a range of non-transfemoral TAVI access techniques from PCR London Valves 2024. Discover alternative approaches such as transiliac, transsubclavian, and transcaval access, employed to overcome complex anatomical challenges. Learn how to navigate tortuous vasculature, snare-assisted TAVR, and transform access when traditional...
Insights from real-world and post-market evidence on Tricuspid TEER
26 Nov 2024 – From PCR London Valves 2024
In this video, Mirjam Wild, Tobias Kister, and Jonathan Byrne discuss real-world evidence from transcatheter edge-to-edge repair, focusing on the TriCLASP and PACE registries. These studies evaluate the PASCAL Precision system for tricuspid regurgitation and its impact on clinical practice.
This interview was filmed at PCR London...
Minimally invasive mitral valve surgery - Staying ahead of the game
25 Nov 2024 – From PCR London Valves 2024
Ready to stay ahead in minimally invasive mitral valve surgery? Don't miss this video!
You’ll explore advanced surgical treatment options for valve diseases, learn how the pathophysiology of mitral and tricuspid regurgitation impacts surgical repair techniques, weigh the pros and cons of interventional and surgical approaches for...
Featured cases - Paravalvular leak closure
24 Nov 2024 – From PCR London Valves 2024
Dive into a captivating session showcasing selected PCR London Valves 2024 clinical cases on paravalvular leak closure. Witness the use of a hybrid approach for aortic paravalvular leaks, the management of infective endocarditis complications, and the percutaneous treatment of complex malpositioned valves. Explore interventions to address...
Tricuspid valve intervention - Current devices and future perspectives
24 Nov 2024 – From PCR London Valves 2024
Curious about how to tackle the challenges of tricuspid valve interventions? This video dives into the latest devices and strategies, showing you how to select the right approach for each patient.
Watch experienced practitioners treat real-world cases, from atrial functional regurgitation to large annulus gaps and complex...
TEER for primary mitral regurgitation - LIVE case
15 May 2024 – From EuroPCR 2024
A 76-year-old male, with previous CABG in 2015, hypertension, diabetes, and pulmonary hypertension (WHO2), presented with severe symptomatic primary MR (P3 flail).
The operators implanted 1 MitraClip (XTW) step-by-step, from the transseptal puncture to the closure, guided by TEE echo and under general anaesthesia, via the venous...
When the pulmonary valve is the problem
14 May 2024 – From EuroPCR 2024
This session will feature a series of selected clinical case submissions from EuroPCR 2024, focusing on the management of pulmonary valve-related issues. Attendees will have the opportunity to explore various scenarios, including pulmonary balloon valvotomy in dextrocardia, transcatheter pulmonary valve implantation in dilated right ventricular outflow...
Contemporary surgical and transcatheter approaches for multivalve disease
21 Nov 2023 – From PCR London Valves 2023
Explore modern surgical and transcatheter strategies for addressing multivalve disease in this session: gain in-depth knowledge about the current approaches in both surgical and transcatheter management of multivalve disease, develop a profound understanding of algorithms guiding the identification of the dominant valve lesion and shaping procedural...
Mitral valve intervention in complex scenarios - Transcatheter paravalvular leak closure
21 Nov 2023 – From PCR London Valves 2023
Everything you need to know about mitral PVL and transcatheter closure is outlined in this session: clinical implications, indications for transcatheter closure, role of imaging, necessary access and equipment, and even tips for difficult anatomies.
How to treat my patient with primary mitral regurgitation?
20 Nov 2023 – From PCR London Valves 2023
In this session, study the different cases of primary mitral regurgitation in detail, with diagrams, videos and even recommendations, to find out when to opt for replacement rather than repair, how to better manage transcatheter mitral replacement, and how to get to grips with endoscopic mitral...
Key questions in tricuspid valve intervention - How does the role of the right heart and pulmonary vasculature influence patient selection?
19 Nov 2023 – From PCR London Valves 2023
Explore insights from an 86-year-old female patient's case with TAVR since end-2022 who presented with permanent AF, moderate MR and TR regurgitation, and learn more about right heart catheterisation for patient selection, CT and CMR in tricuspid interventions, criteria for atrial secondary TR, and more!
Valve-in-valve - LIVE case
17 May 2023 – From EuroPCR 2023
Study the case of a 76-year-old female patient with BMI 32, atrial fibrillation, diabetes, mid chronic kidney disease and history of aortic stenosis, whose Perimount Magna Ease 21 (mismatch) surgical bioprosthesis, implanted in 2016, degenerated, with preserved left ventricular function.
An Evolut Pro 26 was implanted in...
AfricaPCR 2023: Closing Ceremony
04 Mar 2023 – From AfricaPCR 2023
Beyond all the thanks that should naturally be expressed at the time of closing this new edition of AfricaPCR, this closing ceremony is also an opportunity to remind that the contents of this course remain available on our platforms and social networks, and that the appointment...
How should I treat a patient with bifurcation coronary disease - A patient's journey
04 Mar 2023 – From AfricaPCR 2023
Consider the case of a 66-year-old male patient with no previous cardiac history, but HTN for 20 years, presenting after a successfully thrombolysed inferior STEMI within the 12 hours, no other immediately obvious risk factor for IHD, good baseline functional capacity and normal bio-profile, and compare...
Intervention makes a difference
04 Mar 2023 – From AfricaPCR 2023
This AfricaPCR 2023 session includes presentations of 5 cases highlighting the importance of percutaneous interventions, which often have a considerable impact on the patients who undergo them.
AfricaPCR 2023: Opening Ceremony
03 Mar 2023 – From AfricaPCR 2023
After 3 years without a physical Course, it is with great pleasure that the speakers open this new edition of AfricaPCR. They begin by recalling the values of this Course and presenting its Directors, then they unfold the programme by underlining the strong points and also...
TAVI for bicuspid aortic valve - LIVE case
03 Mar 2023 – From AfricaPCR 2023
Watch how this 80-year-old man with severe, symptomatic, heavily calcified bicuspid aortic stenosis, who initially presented with NSTEMI, was treated, and learn about a simplified step-by-step TAVI procedure.
Balloon valvuloplasty was performed, followed by LAD PCI with a rotablator and stent, prior to the TAVI procedure, which...
Challenging femoral access and alternative access
03 Mar 2023 – From AfricaPCR 2023
In this session, learn about femoral artery dissection after TAVI, femoral perforation, alternative access for TAVI, and follow discussions about the safest way to perform transfemoral access, among others!
Mitral edge-to-edge repair: surgical and transcatheter approaches - LIVE case
29 Nov 2022 – From PCR London Valves 2022
Learn from these 2 cases of primary mitral repair using percutaneous and surgical approaches:
- LIVE case - A 90-year-old male with history of LAD PCI 23 years ago and paroxysmal atrial fibrillation presents a primary mitral regurgitation (P2 prolapse) on mildly dilated LV and preserved LV function.
The operators...
