Simone Biscaglia
Latest contributions
CT and intracoronary imaging evaluation of coronary disease
21 May 2026 – From EuroPCR 2026
This session focuses on advanced imaging modalities for evaluating coronary artery disease, including the clinical application of CT angiography and intracoronary imaging techniques like OCT and IVUS. Topics encompass barriers to OCT usage, the impact of plaque composition on PCI outcomes, advances in photon-counting CT technology,...
Where to leave less behind: non-invasive CT and angiography-derived physiology for DCB lesion selection
20 May 2026 – From EuroPCR 2026
This session elucidates the role of non-invasive coronary CT and angiography-derived physiology in guiding lesion selection for drug-eluting balloon PCI. It emphasises integrating anatomical and physiological data to refine lesion preparation, strategy, and validation beyond angiography, and identifies scenarios where DEB PCI may not be optimal,...
Angiography-based physiology: time to change your routine clinical practice?
20 May 2026 – From EuroPCR 2026
This session offers a critical appraisal of angiography-based physiology, with a focus on virtual fractional flow reserve (vFFR) technology. It reviews the latest clinical evidence, including insights from the FAST study programme and the FAST III randomised controlled trial. Gain a clear understanding of current guideline...
Artificial intelligence-powered precision: CT-guided PCI and the future of image-guided therapy
19 May 2026 – From EuroPCR 2026
Image-guided PCI is entering a new era, driven by artificial intelligence and advanced CT technologies that are reshaping how coronary interventions are planned and performed.
This EuroPCR 2026 session explores the integration of photon-counting CT into PCI workflows, highlighting its improved spatial resolution, enhanced plaque characterisation and...
Physiology-guided PCI: LIVE Educational Case from Sant'Andrea University Hospital - Rome, Italy
19 May 2026 – From EuroPCR 2026
This educational session presents a live, physiology-guided PCI case from Sant'Andrea University Hospital, Rome. It emphasizes the role of integrated functional imaging in procedural planning, discusses treatment strategies for multivessel disease and long lesions, and demonstrates a step-by-step fractional flow reserve (FFR)-guided PCI approach.
Angiography-derived coronary physiology: will it change my practice?
11 Apr 2025
Discover what D. Milasinovic and S. Biscaglia shared on the practice of Angiography-derived coronary physiology.
Heart to Heart Conversations podcasts – expert insights in interventional cardiology, anytime, anywhere
06 Feb 2025
Stay ahead in interventional cardiology with Heart-to-heart podcasts, the audio companion to our acclaimed webinar series.
Multivessel disease in ACS - which lesions to treat and when
21 May 2024
Watch the replay of this webinar with S. Biscaglia, V. Paradies and P. Smits on how to learn about new evidence for complete revascularisation in ACS and much more!
Role of PCI in the contemporary management of patients with angina and coronary disease
17 May 2024 – From EuroPCR 2024
This session aims to generate awareness about the distinct phenotypes of coronary artery disease (focal, diffuse, serial) that can be identified through contemporary physiological tools, and the implications of these phenotypes on achieving successful functional PCI results. Participants will also discuss the considerations around using PCI...
Multivessel disease PCI guided by physiology and IVUS - LIVE case
16 May 2024 – From EuroPCR 2024
A 78-year-old woman with hypertension, dyslipidemia, and obesity, presented with angina CCS2 and preserved LV function. The coronary angiogram showed stenosis in the RCA (proximal and mid), CX, and calcified proximal and mid LAD involving D1 and D2.
The operators performed PCI on the RCA (1 stent)...
Supraflex Cruz - Improving patient outcomes: from simple to complex patients
14 May 2024 – From EuroPCR 2024
Discover the remarkable performance of Supraflex Cruz in real-world clinical settings, showcasing exceptionally low event rates and demonstrating its safety and efficacy across a spectrum of high-risk patients, including the elderly and those with high bleeding risks, and delve into the ongoing TALENT and TUDEXO II...
FIRE trial: physiology-guided complete PCI in older MI patients
27 Aug 2023
Luis Ortega-Paz interviews Simone Biscaglia and Gianluca Campo about the FIRE trial.
Results showed elderly patients presenting with either STEMI or NSTEMI benefit from complete revascularization, reducing cardiovascular events risk at 1 year compared to culprit lesion-only PCI.
Published simultaneously in the New England Journal of Medicine

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Left main and bifurcation PCI in NSTEMI
19 May 2022 – From EuroPCR 2022
View cases on OCT and jailed balloon technique, imaging-guided LMS bifurcation PCI, crossover stenting in a bifurcation coronary lesion to find out more about left main and bifurcation PCI in NSTEMI.
EuroPCR 2022 Hotlines / Late-Breaking Trials in coronary artery disease: MASTER DAPT, CRUZ-HBR, DISCO RADIAL, and more!
17 May 2022 – From EuroPCR 2022
Find out more about various studies & registries in coronary artery disease! Abbreviated DAPT after complex PCI in high bleeding risk patients, comparing conventional and haemostatic dressings in radial access, angio-based QFR virtual PCI vs. conventional angio-guided PCI, CRUZ-HBR, CT-guided invasive coronary angiography in patients with...
Contemporary adoption of invasive coronary physiology with microcatheter-based technology
19 May 2021 – From EuroPCR 2021
Watch this session presented by Emanuele Barbato, Bernard De Bruyne, Jeroen Sonck, Simone Biscaglia, Salvatore Brugaletta and Carlos Collet in order to understand the role of microcatheter-based physiology also through a critical appraisal of the available literature, to know how to correctly adopt the novel TruePhysio microcatheter, and...