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Left main and multivessel disease

Find all the latest content on left main and multivessel disease published on this website.

The left main coronary artery provides the primary source of blood flow to the left ventricle. Diseases affecting the left main, by itself or in combination with multivessel disease, place the patient at significant risk for life-threatening cardiovascular events. Treatment requires an understanding of all available tools, devices and techniques, like those employed in invasive imaging and functional assessment, as well as taking into account underlying comorbidities such as diabetes. Advances in imaging techniques, as well as the use of adjunctive pharmacotherapy, vascular access or invasive interventions such as bypass surgery, are important, as are understanding bleeding risks. Use the filters below to access PCRonline resources.

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Left main and multivessel disease

422 results

MULTISTARS AMI: Multivessel immediate versus staged revascularization in STEMI

28 Aug 2023

Aaysha Cader interviews Barbara Elisabeth Stahli on the study design and results that she presented during the ESC Congress 2023 in Amsterdam. 

Immediate multivessel PCI was non-inferior to staged multivessel PCI for reducing death and ischemic events in patients with STEMI and multivessel coronary artery disease.

Author

Aaysha Cader
Barbara Stähli

Author

Barbara Stähli
MULTISTARS AMI

FIRE trial: physiology-guided complete PCI in older MI patients

27 Aug 2023

Luis Ortega-Paz interviews Simone Biscaglia and Gianluca Campo about the FIRE trial.
Results showed elderly patients presenting with either STEMI or NSTEMI benefit from complete revascularization, reducing cardiovascular events risk at 1 year compared to culprit lesion-only PCI.

Published simultaneously in the New England Journal of Medicine

Luis Ortega-Paz

Author

Luis Ortega-Paz
Simone Biscaglia

Author

Simone Biscaglia
Gianluca Campo

Author

Gianluca Campo
FIRE trial: physiology-guided complete PCI in older MI patient

Percutaneous coronary intervention vs coronary artery bypass graft surgery for left main disease in patients with and without acute coronary syndromes: a pooled analysis of 4 randomized clinical trials

05 Jul 2023

This patient-level analysis of randomized trials comparing PCI vs CABG for the treatment of low-to-intermediate CAD involving the LM confirms the absence of long-term differences in mortality between revascularization techniques, regardless of the clinical presentation.

Giovanni Occhipinti

Reviewer

Giovanni Occhipinti
Daniele Giacoppo

Reviewer

Daniele Giacoppo
PCI vs CABG surgery for LM disease in patients with and without ACS: a pooled analysis of 4 randomized clinical trials

PCI or CABG for left main coronary artery disease: the SWEDEHEART registry

28 Jun 2023

While the choice between PCI and CABG for LMCA disease continues to be one of the most controversial topics, patient characteristics & comorbidities must be taken into account, as must the external validity of the results of RCTs in the real world, as the SWEDEHEART registry does.

Panagiotis Xaplanteris

Reviewer

Panagiotis Xaplanteris

Reviewer

Leonidas Koliastasis
PCI or CABG for left main coronary artery disease: the SWEDEHEART registry

Die Hard: high-risk PCI in calcified LM and severe LV dysfunction

14 Jun 2023

How would you treat an extremely calcified sub-occluded LM in a 72-year-old man presenting on "dependent stability and sliding on inotropes"(*), refused by surgery?

(*) INTERMACS III to II

Author

Flavio Luciano Ribichini
Gabriele Pesarini

Author

Gabriele Pesarini
Mattia Lunardi

Author

Mattia Lunardi
Die Hard: high-risk PCI in calcified LM and severe LV dysfunction

When it’s (really) tight

23 Jun 2023

A 71-year-old woman was referred for coronary angiography. She underwent SAVR for AS related to bicuspidia 6 months before, and subsequently suffered from angina and increasing dyspnea 4 months after the intervention...

Author

Vincent Balmette
Nicolas Amabile

Author

Nicolas Amabile

Author

Aurélie Veugeois
When it’s (really) tight

Multivessel disease PCI guided by physiology and intracoronary imaging - LIVE case

19 May 2023 – From EuroPCR 2023

A 68-year-old non-diabetic male patient presented with recent exertional chest pain and good LV function. Baseline angiography revealed severe stenosis of the proximal RCA, mid-stenosis of the proximal and mid-CX, and mid-stenosis of the proximal and mid-LAD.

Physiology revealed significant stenosis of proximal CX and proximal LAD.

IVUS...

Multivessel disease PCI guided by physiology and intracoronary imaging - LIVE case

Multivessel disease, which patients for PCI, CABG or medical treatment?

17 May 2023 – From EuroPCR 2023

Because multivessel disease raises many challenges, cardiac surgeon Lenard Conradi and interventional cardiologist Davide Capodanno discuss the biggest ones.

Is invasive coronary angiography really necessary? If revascularisation is required, which patient should be given a PCI rather than a CABG, and vice versa? What is state-of-the-art in surgery in...

Multivessel disease, which patients for PCI, CABG or medical treatment?

Calcified distal left main stenosis - LIVE case

18 May 2023 – From EuroPCR 2023

Watch the case of a 62-year-old non-diabetic male patient with history of stroke and peripheral artery disease, normal ECG and left ventricular function, referred for CT scan and angiography. He presented with calcified distal LM stenosis and calcified proximal LAD stenosis.

Provisional left main stenting was performed,...

Calcified distal left main stenosis - LIVE case

Intracoronary imaging in left main - Part 1

18 May 2023 – From EuroPCR 2023

Explore the world of intracoronary imaging in left main interventions in this session: discover a fascinating case report on overcoming left main stent pop-up, delve into the application of OCT-guided nano crush technique for left main bifurcation lesions, uncover the management of stent failure involving the...

Intracoronary imaging in left main - Part 1