Left main and multivessel disease

Latest left main and multivessel disease content in interventional cardiology - research, practice, and education

The left main coronary artery provides the primary source of blood flow to the left ventricle. Diseases affecting the left main, by itself or in combination with multivessel disease, place the patient at significant risk for life-threatening cardiovascular events. Treatment requires an understanding of all available tools, devices and techniques, like those employed in invasive imaging and functional assessment, as well as taking into account underlying comorbidities such as diabetes. Advances in imaging techniques, as well as the use of adjunctive pharmacotherapy, vascular access or invasive interventions such as bypass surgery, are important, as are understanding bleeding risks. Use the filters below to access PCRonline resources.

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Left main and multivessel disease

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Through decisions in complex left main PCI – Left main trifurcation

22 May 2025 – From EuroPCR 2025

This session offers an in-depth analysis of complex left main trifurcation PCI, covering evaluation through imaging and physiology, lesion preparation strategies, and treatment options including stepwise provisional approaches, upfront two-stent techniques, and drug-coated balloons.

Through decisions in complex left main PCI – Left main trifurcation

How to correct incomplete crush and how to prevent lack of carina coverage

  • Differentiating between complete and incomplete crush
  • The importance of sequential crush and bigger balloons, adequately sized according to proximal vessel diameter

Commented by Goran Stankovic and William Wijns

Part 2 of a 3-part series:  
Previous episode: DK Crush like you’ve never seen it before
Coming up next: Main vessel stenting in DK-Crush, lessons...

How to correct incomplete crush and how to prevent lack of carina coverage

How to perform DK-Crush for left main bifurcation stenting

22 May 2025 – From EuroPCR 2025

Including: A clinical case performed live in Poznan, Poland, showing conventional guidance with angiography and intravascular imaging
Modern technology: machine learning, AI and 3D (multiple simulation techniques)

A series of 3 episodes

How to perform DK-Crush for left main bifurcation stenting

PCI for complex calcific coronary artery disease - LIVE Case

22 May 2025 – From EuroPCR 2025

An 87-year-old female patient, at high bleeding risk and with preserved LV function, presented 2 months ago with an inferior STEMI and multivessel disease. She initially underwent RCA PCI followed by staged LCx PCI. She was now referred for PCI of a long, heavily calcified lesion...

PCI for complex calcific coronary artery disease - LIVE Case

Complex multivessel disease - LIVE Case

21 May 2025 – From EuroPCR 2025

An 89-year-old male patient presented with stable angina, preserved LV function and some risk factors such as hypertension and diabetes. CT scan and angiography revealed occlusion of proximal RCA and bifurcation lesions on LAD and circumflex (medina 1,1,1). Operators treated the bifurcation lesions with provisional stenting.
Regarding...

Complex multivessel disease - LIVE Case

First guidelines for the treatment of LM disease issued by SOLACI and SIAC

22 May 2025 – From EuroPCR 2025

During EuroPCR 2025, Cleverson Zukowski and Pablo Lamelas introduce a landmark initiative: the first clinical guidelines for left main disease specifically developed for Latin America.

Published by the Latin American Society of Interventional Cardiology (SOLACI) and the Interamerican Society of Cardiology (SIAC), these recommendations aim to support...

First guidelines for the treatment of LM disease issued by SOLACI and SIAC

How to manage treatment dilemmas in STEMI patients with multivessel disease?

20 May 2025 – From EuroPCR 2025

Managing STEMI patients with multivessel disease is a complex challenge evolving rapidly thanks to new clinical evidence. Angela Mcinerney, Natalia Pinilla, and Matthias Götberg explore how findings from the COMPLETE trial and its intracoronary imaging substudy are reshaping treatment strategies.

Their discussion highlights the role of intracoronary...

How to manage treatment dilemmas in STEMI patients with multivessel disease?

How to efficiently and safely manage calcified left main disease?

21 May 2025 – From EuroPCR 2025

Nicola Ryan and Flavio Ribichini explore the complexities of calcified left main stem disease, emphasizing the critical role of intracoronary imaging in improving patient outcomes. They discuss the practical use of mechanical circulatory support and debate stenting strategies, offering expert insights on when single or dual...

How to efficiently and safely manage calcified left main disease?

Feasibility of sheathless Impella for protected percutaneous coronary intervention: a single-center experience

02 May 2025

Impella CP microaxial flow pump supports complete revascularisation during high-risk PCI, but standard implantation often leads to vascular complications. This article explores an initial experience with a sheathless implantation technique, which shows promise as a feasible and safe alternative.

Sheathless Impella PCI

How should I treat a left main disease with multivessel diffuse CAD? Stenting only the necessary...

28 Feb 2025

A 71-year-old male patient with a clinicial history of hypertension, dyslipidemia and active smoking was admitted for NSTEMI.

Coronary angiography showed a left main (LM) stenosis involving the bifurcation and proximal parts of the left anterior descending (LAD) and left circumflex (LCx) arteries. Right coronary artery (RCA) showed a severe...

Eva Rumiz

Author

Eva Rumiz
How should I treat a left main disease with multivessel diffuse CAD? Stenting only the necessary