Left main and multivessel disease

Latest left main and multivessel disease content in interventional cardiology - research, practice, and education

The left main coronary artery provides the primary source of blood flow to the left ventricle. Diseases affecting the left main, by itself or in combination with multivessel disease, place the patient at significant risk for life-threatening cardiovascular events. Treatment requires an understanding of all available tools, devices and techniques, like those employed in invasive imaging and functional assessment, as well as taking into account underlying comorbidities such as diabetes. Advances in imaging techniques, as well as the use of adjunctive pharmacotherapy, vascular access or invasive interventions such as bypass surgery, are important, as are understanding bleeding risks. Use the filters below to access PCRonline resources.

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Left main and multivessel disease

371 results

EuroPCR 2026 – Long-term mortality following revascularisation for left main disease

20 May 2026

Paris, France, 19−22 May 2026. The EuroPCR Course Directors have selected 3 major late-breaking trials that will be presented for the first time during EuroPCR 2026 and are set to impact practice worldwide. Among them is a meta-analysis of long-term data from 4 randomised trials investigating...

EuroPCR 2026 – Long-term mortality following revascularisation for left main disease

Main vessel stenting in DK-Crush: lessons from stepwise provisional strategy

  • Optimisation of side branch stenting
  • How to optimally deploy the second stent

Commented by Goran Stankovic and William Wijns

Part 3 of a 3-part series. Previous episode: How to correct incomplete crush and how to prevent lack of carina coverage

Main vessel stenting in DK-Crush: lessons from stepwise provisional strategy

DK Crush like you’ve never seen it before

  • Multi-modality simulation to unveil the hidden parts & small obstacles that can result in complications
  • Angioscopy directly inside the coronary artery to provide a better understanding of 3D stent configuration

Commented by Goran Stankovic and William Wijns

Part 1 of a 3-part series.
Next episode: How to correct incomplete crush and...

DK Crush like you’ve never seen it before

NOBLE trial: 10-year outcomes of PCI vs CABG in left main disease

13 Apr 2026

Long-term evidence comparing PCI and CABG for unprotected left main coronary disease has been limited and sometimes conflicting. The 10-year results from the NOBLE trial now provide important clarity on all-cause mortality outcomes with both revascularisation strategies.

Ruxandra Sava

Reviewer

Ruxandra Sava
PCI vs CABG in left main disease: 10-year NOBLE results

Coronary calcification versus thrombus: a deceptive ambiguity revealed in the aftermath of embolisation

07 Apr 2026

Discriminating between coronary calcification and thrombus in acute settings remains a diagnostic challenge with significant implications for interventional decision-making.

Imran Hanif Hashmi

Author

Imran Hanif Hashmi
Minahil Tariq Sheikh

Author

Minahil Tariq Sheikh
Ahmad Usama Wali

Author

Ahmad Usama Wali
Coronary calcification versus thrombus: a deceptive ambiguity revealed in the aftermath of embolisation

IVUS-guided versus angiography-guided PCI in unprotected left main coronary artery disease – The OPTIMAL trial

31 Mar 2026

Ali Nazmi Calik provides his take on the results of the OPTIMAL trial presented by Luca Testa at ACC.26 in New Orleans.

Author

Ali Nazmi Calik
Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in unprotected left main coronary artery disease – The OPTIMAL trial

It is a calcified left main: do it well, do it safely

28 Feb 2026 – From Euro4C Annual Meeting 2026

This session addresses the complexities of percutaneous coronary intervention (PCI) in calcified left main coronary artery disease. It covers comprehensive planning including mechanical circulatory support, intravascular imaging, and bifurcation strategies. Attendees will also learn to anticipate and manage potential complications and apply various tools to ensure...

It is a calcified left main: do it well, do it safely

Impact of complete revascularisation in relation to left ventricular function in patients with ST-segment elevation myocardial infarction and multivessel disease: a post hoc analysis of the COMPLETE randomised trial

05 Feb 2026

This study represents a prespecified subgroup analysis of the COMPLETE randomised trial, a large, international, randomised controlled study comparing a strategy of complete revascularisation with culprit-only percutaneous coronary intervention (PCI) in patients presenting with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease (MVD).

The present...

Murat Gökalp

Reviewer

Murat Gökalp

Reviewer

Ali Nazmi Calik
LV function after complete revascularisation in STEMI and MVD insights from the COMPLETE trial

Left main and LAD bifurcation - LIVE Case

30 Jan 2026 – From SASCI-AfricaPCR

A 59‑year‑old man with a history of STEMI in 2019 (Cx PCI), as well as hypertension and dyslipidemia, presented with CCS class III angina. Coronary angiography revealed a chronic total occlusion (CTO) of the OM2 and a calcified ostial lesion of the LAD and first diagonal...

Left main and LAD bifurcation - LIVE Case

Provisional stenting for a distal left main stenosis - LIVE Case

10 Dec 2025 – From GulfPCR-GIM 2025

A 66-year-old male with preserved LV function, type II diabetes, and hypertension, presented with CCS and anterior ischemia, with a normal ECG. Photon-counting CT revealed a significant calcified stenosis of the distal left main and proximal LAD, confirmed by coronary angiography.

A stent was implanted in the...

Provisional stenting for a distal left main stenosis - LIVE Case