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TAVI for aortic regurgitation in high surgical risk: outcomes in 700 patients from ALIGN-AR

12 Feb 2026 – From PCR London Valves 2025

Christopher Allen and Raj Makkar sit down to review the ALIGN-AR trial and its implications for treating native aortic regurgitation. 

ALIGN-AR was a pivotal, single-arm, multicenter investigational study designed to evaluate a dedicated transcatheter solution in patients with moderate-to-severe native AR who were considered high risk for...

Outcomes in 700 patients from ALIGN-AR regarding TAVI for AR in high surgical risk

The D-PACE scoring system Prediction of high-grade conduction disturbances after TAVI

16 Nov 2025 – From PCR London Valves 2025

Michael Joner and Francesco Saia discuss the newly developed D-PACE Score, a tool designed to predict delayed AV block occurring more than 24 hours after TAVI—an unmet clinical need given that current risk models focus mainly on early events. The next steps aim to refine the...

The D-PACE scoring system - Can we predict high-grade conduction disturbances after TAVI?

Why is TAVI a different procedure in patient with pure aortic regurgitation?

15 Nov 2025 – From PCR London Valves 2025

In this video, Juan Granada, Michael Borger and Joao Cavalcante highlight that aortic insufficiency differs from aortic stenosis and is often underestimated. Early, comprehensive evaluation and imaging are crucial. Surgery is standard for severe cases, while TAVI with dedicated devices is an option for high-risk patients.

This...

Why is TAVI a different procedure in patient with pure aortic regurgitation?

What are the key considerations for transcatheter mitral paravalvular leak management?

18 Nov 2025 – From PCR London Valves 2025

Nina Wunderlich and Patrick Calvert discuss mitral paravalvular leaks, which are relatively common. Percutaneous closure is now the default approach, and imaging is central to success: detailed pre-procedural assessment, 3D TOE during the procedure, and careful planning of transseptal puncture. 

This interview was filmed at PCR London...

What are the key considerations for transcatheter mitral paravalvular leak management?

What are the key steps in pre procedural assessment for successful LAA closure?

17 Nov 2025 – From PCR London Valves 2025

Lorenz Räber and Kasper Korsholm highlight why pre-procedural imaging—particularly cardiac CT—has become essential for successful left atrial appendage occlusion (LAAO). They explain that the LAA is highly variable between patients, making detailed planning crucial for safety, device selection, and optimal procedural results.

This interview was filmed at...

What are the key steps in pre procedural assessment for successful LAA closure?

Featured research: advances in TAVI for aortic regurgitation and severe stenosis

16 Nov 2025 – From PCR London Valves 2025

This session delivers an in-depth analysis of innovative research in transcatheter aortic valve implantation (TAVI). It includes pivotal studies such as the LANDMARK trial subanalysis on cardiac damage in severe aortic stenosis patients, long-term efficacy comparisons of balloon- and self-expanding valves, and evaluations of valve performance...

Featured research: advances in TAVI for aortic regurgitation and severe stenosis

How to manage patients with aortic stenosis and coronary artery disease?

04 Mar 2026 – From PCR London Valves 2025

Tiffany Patterson and Davide Capodanno address the increasingly common scenario of managing coronary artery disease (CAD) in patients undergoing TAVI. With up to half of TAVI candidates presenting with CAD, they highlight new evidence from NOTION-3 showing that revascularization reduces major adverse cardiac events. The takeaway:...

How to manage patients with aortic stenosis and coronary artery disease?

TAVI: high coronary risk

16 Nov 2025 – From PCR London Valves 2025

This session addresses the complexities and innovative approaches to managing high coronary risk during TAVI procedures. It features advanced techniques such as the double chimney-stent method, valve-in-valve strategies to prevent coronary obstruction, and challenging cases involving TAVI-in-TAVI. These insights provide practical guidance for interventionalists navigating high-risk...

When the first TAVI fails: no panic, just planning

19 Jan 2026

An 81-year-old man with history of severe aortic stenosis previously treated with a balloon-expandable transcatheter valve was referred for progressive exertional dyspnea due to bioprosthetic valve degeneration.

How would you treat this patient?

Barbara Bellini

Author

Barbara Bellini
When the first TAVI fails: no panic, just planning

TAVI: nightmare in the cathlab - Cardiac arrest, aortic root rupture & duct occluder

16 Nov 2025 – From PCR London Valves 2025

Explore critical complications encountered during TAVI procedures in this session, which highlights urgent scenarios such as cardiac arrest from calcific leaflet shift, aortic root rupture, and embolisation events. It also covers salvage techniques like TAVR-in-TAVR-in-SAVR in cardiogenic shock and management of acute left main occlusion with...

TAVI: nightmare in the cathlab - Cardiac arrest, aortic root rupture & duct occluder

Spotlight on a selection of top Late-breaking Trials presented at PCR London Valves 2025

17 Nov 2025

View a snapshot of the results of these 4 trials in valvular and structural interventions presented in London during this year's Heart Team Course!

Selection of top Late-breaking Trials presented at #PCRLV

Validation of intravascular ultrasound-defined optimal stent expansion criteria for favorable 1-year clinical outcomes

17 Nov 2025

This individual patient data analysis of the three largest RCTs evaluating IVUS-guided stent optimisation showed that an MSA > 5.5 mm2 was associated with reduced TVF at one year. 

Ruxandra Sava

Reviewer

Ruxandra Sava
Nicola Ryan

Reviewer

Nicola Ryan
Validation of IVUS-defined optimal stent expansion criteria for favorable 1-year clinical outcomes

PCR: Collaborative, inclusive and global

15 Nov 2025 – From PCR London Valves 2025

At PCR, collaboration and inclusion are at the heart of everything we do.

Together, we create an environment where expertise is shared, talents complement each other, and diversity becomes a strength. It is this collective spirit that drives interventional cardiology forward and inspires innovation every day.

During PCR London...

PCR: Collaborative, inclusive and global

Challenging mitral TEER: overcoming access limitations and anatomical challenges

16 Nov 2025 – From PCR London Valves 2025

This session delves into the challenges of mitral transcatheter edge-to-edge repair (TEER), focusing on complex cases such as denied access, patch dehiscence-induced regurgitation, and functional mitral regurgitation due to amyloid cardiomyopathy. It also highlights innovative imaging approaches, including the use of transthoracic echocardiography as a rescue...

Challenging mitral TEER: overcoming access limitations and anatomical challenges

Meril Life Sciences presents one-year outcomes from the LANDMARK randomized controlled trial at PCR London Valves 2025

16 Nov 2025

GulfPCR-GIM 2025: the Training Programme is now available!

Check out details of the GulfPCR Workshops taking place in the Training Village
Get an overview of what’s in store!

Challenging tricuspid TEER

16 Nov 2025 – From PCR London Valves 2025

This session focuses on the intricacies of transcatheter tricuspid edge-to-edge repair (TEER) addressing iatrogenic tricuspid regurgitation, failed surgical valve repair, and approaches for patients unsuitable for valve replacement. It also examines the management of multiple clip detachments and the procedural nuances required to navigate complex tricuspid...

PCR London Valves 2025 Welcome Ceremony

16 Nov 2025 – From PCR London Valves 2025

The PCR London Valves 2025 Welcome Ceremony marks the commencement of the conference, setting the stage for an immersive exploration of the latest advances and innovations in valvular heart disease management with a focus on transcatheter interventions.

PCR London Valves 2025 Welcome Ceremony

Complex combined interventions

16 Nov 2025 – From PCR London Valves 2025

This session presents complex combined interventions tackling multiple valvular and structural heart challenges simultaneously. It highlights innovative procedural approaches such as the 'super combo' techniques, strategies for managing deteriorative mitral regurgitation post-tricuspid valve replacement, and comprehensive management of torrential tricuspid regurgitation within rheumatic multivalvular disease contexts,...

Getting the full potential of the supra-annular valve in a changing landscape

16 Nov 2025 – From PCR London Valves 2025

This session explores the evolving landscape of transcatheter aortic valve implantation (TAVI) with a focus on supra-annular valve technology. It covers techniques for achieving commissural alignment, considerations for small aortic annuli, and advantages in treating bicuspid aortic valve disease, supported by clinical data and illustrative cases.

Getting the full potential of the supra-annular valve in a changing landscape
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