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TAV in TAVI with coronary protection - LIVE Case

18 Nov 2025 – From PCR London Valves 2025

Watch a LIVE case followed by a recorded case, regarding a 78-year-old female, with a previous TAVI in 2014 (Sapien 3 26) and sarcoidosis, who presented with symptomatic TAVI stenosis. There was a mis-commissural alignment, with the neoskirt plane above the coronary plane. Under general anesthesia,...

TAV in TAVI with coronary protection -  LIVE Case

Paravalvular leak closure - Part 4

18 Nov 2025 – From PCR London Valves 2025

This session delves into the complexities of paravalvular leak closure with a focus on challenging scenarios including unusual TAVI complications in the mitral position, management of mega paravalvular leaks using jumbo devices, and strategies when closure itself poses an obstacle. It also covers acute peri-operative aortic...

Curious TAVI scenarios - Part 3

18 Nov 2025 – From PCR London Valves 2025

This session examines unusual and challenging clinical scenarios following TAVI, including presentations of cyanosis, evolving valvular defects such as growing paravalvular holes, atypical imaging findings, paradoxical transvalvular gradients switching from aortic regurgitation to stenosis resolved by postdilatation, and bicoronary protection techniques in patients with low coronary...

Featured research - TAVI - Part 14

18 Nov 2025 – From PCR London Valves 2025

This featured research session presents pivotal findings on transcatheter aortic valve implantation (TAVI), including 30-day and one-year outcomes from the VANTAGE trial, novel concepts for assessing aortic stenosis severity, and the influence of mitral annular calcification on conduction disturbances. Additional topics cover the role of clinical...

TAVI - Haemodynamic performance and valve durability

18 Nov 2025 – From PCR London Valves 2025

This session provides an in-depth exploration of haemodynamic performance and valve durability following transcatheter aortic valve implantation (TAVI). Attendees will gain a comprehensive understanding of the differences between invasive and echocardiographic gradients post-TAVI, evaluate the haemodynamic profiles of various transcatheter valve platforms, and appreciate their implications...

TAVI - Haemodynamic performance and valve durability

Complex combined transcatheter interventions

18 Nov 2025 – From PCR London Valves 2025

This session addresses complex combined transcatheter interventions for multivalvular heart disease. It covers integrated transcatheter strategies for multiple valve pathologies, solutions for combined severe aortic stenosis and mitral regurgitation with heavy calcification, and approaches to concomitant atrial functional mitral and tricuspid regurgitation. The session also discusses...

TAVI: complex vascular access - Part 3

18 Nov 2025 – From PCR London Valves 2025

This session focuses on managing complex vascular access challenges in TAVI procedures. It includes case discussions on non-crossable aortic valve stenosis, transseptal TAVI for severe aortic regurgitation with porcelain aorta, and percutaneous implantation in patients with unconventional anatomy or conditions like shaggy syndrome. Strategies for severe...

Complications of paravalvular leak closure

18 Nov 2025 – From PCR London Valves 2025

This session addresses the complexities and risks associated with paravalvular leak (PVL) closure. It offers detailed analysis of principal complications, prevention techniques, and practical management strategies shared by experienced operators. Case studies illustrate complications such as device embolisation, prosthetic valve disc impingement, and delivery failures, along...

PACMAN AMI: Effects of Alirocumab on Coronary Atherosclerosis Assessed by Serial Multimodality Intracoronary Imaging in Patients With Acute Myocardial Infarction

03 Apr 2022

Nicola Ryan provides a PICOT analysis of PACMAN AMI: a double-blind, placebo-controlled, randomized trial presented at ACC 2022 and simultaneously published in JAMA.

Nicola Ryan

Author

Nicola Ryan
PACMAN AMI: Effects of Alirocumab on Coronary Atherosclerosis Assessed by Serial Multimodality Intracoronary Imaging in Patients With Acute Myocardial Infarction: A Double-blind, Placebo-controlled, Randomized Trial

Impact of intravascular imaging guidance on percutaneous coronary intervention of severely calcified lesions: The ECLIPSE trial

29 Mar 2025

Aaysha Cader provides her take on the ECLIPSE trial presented by Gregg W. Stone at ACC.25 in Chicago.

Author

Aaysha Cader
Impact of intravascular imaging guidance on percutaneous coronary intervention of severely calcified lesions: The ECLIPSE trial

BRIGHT-4 – Bivalirudin plus a high-dose infusion versus heparin monotherapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a randomised trial

07 Nov 2022

Nicola Ryan provides her take on the BRIGHT-4 study, which was presented during AHA 2022 in Chicago, & simultaneously published in the Lancet.

This study was a randomised control trial designed to assess if bivalirudin plus a high dose infusion for 2-4 hours post PPCI was superior to unfractionated...

Nicola Ryan

Author

Nicola Ryan
BRIGHT-4 – Bivalirudin plus a high-dose infusion versus heparin monotherapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a randomised trial

Comparison of a precision care strategy with usual testing to guide management of stable patients with suspected CAD: the PRECISE randomized trial

09 Nov 2022

Alex Sticchi provides his take on PRECISE, which was presented during AHA 2022 in Chicago.

Alessandro Sticchi

Author

Alessandro Sticchi
Comparison of a precision care strategy with usual testing to guide management of stable patients with suspected coronary artery disease: the PRECISE randomized trial
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