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Featured research - Mitral valve interventions: Physiology & device innovation

17 Nov 2025 – From PCR London Valves 2025

This session highlights groundbreaking research on mitral valve interventions featuring advanced transcatheter techniques. Topics include coronary physiology assessment with vFFR in severe mitral regurgitation, predictive versus actual outcomes in TMVR, innovative devices like Epygon and INNOVALVE, and novel approaches such as the ReNiva posterior leaflet replacement...

Featured research - Mitral valve interventions: Physiology & device innovation

Left atrial appendage occlusion

17 Nov 2025 – From PCR London Valves 2025

This session focuses on the complexities and innovations in left atrial appendage occlusion (LAAO) procedures. It covers transesophageal ICE monitoring, challenges posed by existing atrial septal occluders, combined surgical and percutaneous approaches, and the practical experience with the Ultraseal device. These insights advance understanding of procedural...

TAVI: complex vascular access

17 Nov 2025 – From PCR London Valves 2025

This session addresses the challenges of complex vascular access in transcatheter aortic valve implantation (TAVI). It discusses strategies for navigating difficult thoraco-abdominal aortic anatomies, managing double aortic arches, and overcoming hostile femoral access. Case studies illustrate meticulous planning and innovative solutions essential for successful TAVI in...

Mitral TEER and LAA closure - LIVE Case

17 Nov 2025 – From PCR London Valves 2025

Watch a LIVE case followed by a recorded case regarding a 91-year-old female with permanent AF, LAD PCI three months earlier, and recurrent GID bleeding who presented with symptomatic severe primary mitral regurgitation due to P2 prolapse and flail. CT imaging showed a LAA with a...

Mitral TEER and LAA closure -  LIVE Case

TAVI: nightmare in the cathlab - Annular perforation, coronary obstruction & balloon rupture

17 Nov 2025 – From PCR London Valves 2025

This session presents critical case analyses of complicated TAVI procedures, highlighting unexpected and severe intra-procedural events such as annular perforation, leaflet modification complications, coronary obstructions, and device failures. It emphasizes prevention strategies, bailout techniques, and acute management to prepare clinicians for handling TAVI-related emergencies effectively.

TAVI: nightmare in the cathlab - Annular perforation, coronary obstruction & balloon rupture

TAVI in patients with concomitant valve and coronary artery disease

17 Nov 2025 – From PCR London Valves 2025

Focused on patients with concomitant valve and coronary artery disease, this session examines evaluation strategies for aortic stenosis burden, integrates recent trial data on combined TAVI and PCI, and discusses optimal management approaches in complex multi-valve disease scenarios through detailed case presentations and clinical outcomes.

TAVI in patients with concomitant valve and coronary artery disease

Challenging mitral TEER: Barlow's disease, fibro-elastic deficiency & abnormal valve morphology

17 Nov 2025 – From PCR London Valves 2025

This session examines the feasibility and technical considerations of mitral transcatheter edge-to-edge repair (TEER) in complex anatomical and pathological scenarios. Topics include applications in Barlow's disease, fibro-elastic deficiency, congenital heart anomalies, Anderson-Fabry disease, and post-cardiac transplantation, providing valuable insights into expanding TEER indications and overcoming anatomical...

Challenging mitral TEER: Barlow's disease, fibro-elastic deficiency & abnormal valve morphology

Pulmonary valve interventions

17 Nov 2025 – From PCR London Valves 2025

This session presents complex cases and innovative solutions in pulmonary valve interventions. It highlights a novel balloon-expandable valve for the right ventricular outflow tract, management of severe prosthetic pulmonary valve stenosis in congenital heart disease, approaches to residual lesions in Fallot's anomaly, treatment of double outlet...

Pulmonary valve interventions

SWISS-APERO: a randomized trial of the amulet versus watchman FLX devices for left atrial appendage closure

04 Nov 2021

The SWISS-APERO is a prospective, investigator-initiated, randomized, multi-center, and clinical trial designed to compare the Amulet and Watchman (2.5 and FLX) devices in a head-to-head fashion.

Francesco Costa

Author

Francesco Costa
SWISS-APERO: a randomized trial of the amulet versus watchman FLX devices for left atrial appendage closure

Coronary arteries

30 Oct 2017

The coronary arteries arise from the aortic sinuses. Read more...

 Coronary arteries

CHOICE-CLOSURE: a randomized trial of plug-based versus suture-based large-bore vascular closure

06 Nov 2021

TCT 2021: Radoslaw Parma reviews the CHOICE-CLOSURE multicentre, randomized, controlled, open-label clinical trial presented by Mohamed Abdel-Wahab. The study compared outcomes of percutaneous femoral artery closure using a plug-based and a primary suture-based strategy in patients undergoing TAVI.

Author

Radoslaw Parma
CHOICE-CLOSURE: a randomized trial of plug-based versus suture-based large-bore vascular closure

The PASCAL IID Registry: A prospective registry for transcatheter edge-to-edge repair in prohibitive risk patients with degenerative mitral regurgitation and complex mitral valve anatomy

17 Sep 2022

Alex Sticchi provides his take on the PASCAL IID Registry and an initial comparison with the CLASP IID. The trial was presented by Jörg Hausleiter during TCT Congress 2022.

Alessandro Sticchi

Author

Alessandro Sticchi
The PASCAL IID Registry: A Prospective Registry for Transcatheter Edge-to-Edge Repair in Prohibitive Risk Patients With Degenerative MR and Complex Mitral Valve Anatomy

Meril presents successful LANDMARK RCT one-year results at prestigious EuroPCR 2025

21 May 2025

Best of #AHA21 Scientific Sessions: coronary and valvular heart disease trials

14 Nov 2021

Vijay Kunadian provides summaries of study designs and findings in Interventional Cardiology released at the 2021 virtual edition of the American Heart Association Congress. View an infographic of the AVATAR late-breaking trial by Ali Nazmi Calik.

Vijay Kunadian

Author

Vijay Kunadian
Best of #AHA21 Scientific sessions

A large-scale, randomized trial of orbital atherectomy vs. conventional balloon angioplasty in severely calcified coronary arteries prior to DES implantation (ECLIPSE)

30 Oct 2024

Nicola Ryan provides her take on the ECLIPSE trial presented by Ajay J. Kirtane at TCT 2024 in Washington.

Nicola Ryan

Author

Nicola Ryan
A large-scale, randomized trial of orbital atherectomy vs. conventional balloon angioplasty in severely calcified coronary arteries prior to DES implantation (ECLIPSE)

Percutaneous transseptal transcatheter mitral valve replacement using a dedicated balloon-expandable valve: 1-year outcomes from the ENCIRCLE trial using the SAPIEN M3

27 Oct 2025

Jonathan Curio provides his take on the ENCIRCLE Trial presented by David Daniels at TCT 2025 in San Francisco.

Jonathan Curio

Author

Jonathan Curio
Percutaneous transseptal transcatheter mitral valve replacement using a dedicated balloon expandable valve: 1 year outcomes from the ENCIRCLE trial using the SAPIEN M3

Early intervention in patients with asymptomatic severe aortic stenosis and left ventricular myocardial fibrosis (EVOLVED)

30 Oct 2024

Ali Nazmi Calik provides his take on the EVOLVED trial presented by Marc Dweck at TCT 2024 in Washington.

Author

Ali Nazmi Calik
Early intervention in patients with asymptomatic severe aortic stenosis and left ventricular myocardial fibrosis (EVOLVED)

NOTION-3 - Percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation

01 Sep 2024

Make the most of the insights from Jacob Thomsen Loenborg’s interview with Chiara De Biase and Ali Nazmi Calik’s article to capture the key takeaways from this trial, simultaneously published in the NEJM, presented at the ESC Congress 2024 in London.

Author

Chiara De Biase
Jacob Lønborg

Author

Jacob Lønborg

Author

Ali Nazmi Calik
NOTION 3
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