How will EARLY-TAVI and NOTION-3 impact TAVI practice?

When is the right time to perform TAVI—and how should coexisting coronary artery disease be managed? In this interview, Liesbeth Rosseel, Davide Capodanno, and Michael Joner tackle these two timely questions. They share key takeaways from the EARLY-TAVI trial, which demonstrated reduced rehospitalisation with early intervention in asymptomatic patients with severe aortic stenosis, and from NOTION-3, which compared PCI and medical management before TAVI in patients with CAD. Their insights point to a shift in clinical strategy, where earlier TAVI and proactive CAD management may redefine future practice.

This interview was filmed at EuroPCR 2025: see more videos here.