Major LBTs from EuroPCR 2025 - Meta-Analysis of individual patient data from the PROTECTED TAVR and BHF PROTECT-TAVI studies

Stroke remains one of the most feared complications of TAVI—for both patients and physicians. In this EuroPCR 2025 video interview, Bernard Prendergast and Rajesh Kharbanda examine the role of cerebral protection during TAVI procedures, in light of two randomised trials: PROTECTED TAVR and BHF PROTECT-TAVI. While neither trial showed a benefit from cerebral protection devices in isolation, a newly presented patient-level meta-analysis offers a more nuanced view. By aligning endpoints and patient characteristics across studies, this combined analysis reveals signals that could refine our understanding of cerebral protection strategies. Tune in for a focused update on this evolving topic.

This interview was filmed at EuroPCR 2025: see more videos here.