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Featured research: clinical outcomes and real-world evidence in modern TAVI practice

16 Nov 2025 – From PCR London Valves 2025

This session presents featured research on Transcatheter Aortic Valve Implantation (TAVI), analyzing clinical impacts of prosthesis oversizing, same-day discharge experiences, and comparative outcomes of intra-annular versus supra-annular self-expanding valves. It also reviews nationwide TAVR data from Germany and meta-analyses assessing TAVI performance in centers without on-site...

Featured research: clinical outcomes and real-world evidence in modern TAVI practice

Featured research: innovations, safety and evolving pathways in modern TAVI care

16 Nov 2025 – From PCR London Valves 2025

This session addresses contemporary challenges in TAVI, including management of acute valve syndrome through service innovations and the application of Valvosoft non-invasive ultrasound therapy in severe aortic stenosis. It also explores complications such as infective endocarditis post-TAVI, evaluates the feasibility of same-day discharge protocols, and assesses...

Featured research: innovations, safety and evolving pathways in modern TAVI care

TAVI and coronary artery disease

16 Nov 2025 – From PCR London Valves 2025

This session focuses on the interplay between TAVI and coronary artery disease, discussing high-risk TAVR cases requiring complex left main PCI with prophylactic ECMO support. It provides guidance on timing and strategies for managing concomitant coronary artery disease in TAVI patients, addressing the critical decision-making process...

Transcatheter tricuspid valve replacement - LIVE Case

18 Nov 2025 – From PCR London Valves 2025

Live case: An 86-year-old male, with a history of PPM, permanent AF, CKD stage 3, and moderately impaired LV function (50–55%), presented with symptomatic torrential mixed TR (tricuspid annular dilatation and pacing lead on the septal leaflet). An Evoque valve was implanted under fluoroscopy and TEE...

Transcatheter tricuspid valve replacement - LIVE Case

The PASCAL IID Registry: A prospective registry for transcatheter edge-to-edge repair in prohibitive risk patients with degenerative mitral regurgitation and complex mitral valve anatomy

17 Sep 2022

Alex Sticchi provides his take on the PASCAL IID Registry and an initial comparison with the CLASP IID. The trial was presented by Jörg Hausleiter during TCT Congress 2022.

Alessandro Sticchi

Author

Alessandro Sticchi
The PASCAL IID Registry: A Prospective Registry for Transcatheter Edge-to-Edge Repair in Prohibitive Risk Patients With Degenerative MR and Complex Mitral Valve Anatomy

EuroPCR 2024 – Short-term data from NOTION-2: TAVR versus SAVI for younger patients with aortic stenosis

15 May 2024

Paris, France, 14-17 May 2024. The Course Directors have selected 3 major Late Breaking Trials (LBTs) that were presented for the first time during the 2024 edition of EuroPCR. These trials were selected on account of their design, outcomes and potential to influence daily clinical practice....

Transcatheter edge-to-edge repair of functional mitral regurgitation in heart failure: Final five-year results from the COAPT Trial

06 Mar 2023

Alex Sticchi & Jonathan Curio provide their take on the clinical trial presented by Gregg W. Stone at the American College of Cardiology Scientific Sessions (ACC.23/WCC).

Jonathan Curio

Author

Jonathan Curio
Alessandro Sticchi

Author

Alessandro Sticchi
Transcatheter edge-to-edge repair of functional mitral regurgitation in heart failure: Final five-year results from the COAPT Trial

MitrAI score: machine learning models to predict mortality at 12, 24, 36 and 48 months in patients with primary and secondary MR treated by TEER

31 Aug 2024

Jonathan Curio provides his take on the MitrAI score study which was presented by Luigi Biasco at ESC Congress 2024 in London.

Jonathan Curio

Author

Jonathan Curio
MitrAI

Controlled ring expansion during aortic valve-in-valve: a proof-of-concept CT-scan analysis

24 Jun 2024

Analyze this EIJ image to see how surgical aortic bioprostheses with expandable ring technology can significantly enhance future ViV procedures.

Controlled ring expansion during aortic valve-in-valve: a proof-of-concept CT-scan analysis

The JenaValve Trilogy™ heart valve system in high surgical risk patients with symptomatic, severe aortic regurgitation: The ALIGN AR Trial

25 Oct 2023

Nicola Ryan provides her take on the ALIGN AR trial which was presented by Vinod H. Thourani at TCT Congress 2023. The Align AR trial is a prospective single-arm investigation device exemption study assessing the safety and efficacy of the Trilogy transcatheter heart valve system in patients with...

Nicola Ryan

Author

Nicola Ryan
Initial Outcomes of the JenaValve Trilogy Transcatheter Aortic Valve Replacement System in High-Risk Patients with Symptomatic Severe Native Aortic Regurgitation (ALIGN-AR)

NOTION-3 - Percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation

01 Sep 2024

Make the most of the insights from Jacob Thomsen Loenborg’s interview with Chiara De Biase and Ali Nazmi Calik’s article to capture the key takeaways from this trial, simultaneously published in the NEJM, presented at the ESC Congress 2024 in London.

Author

Chiara De Biase
Jacob Lønborg

Author

Jacob Lønborg
Ali Nazmi Calik

Author

Ali Nazmi Calik
NOTION 3

Early intervention in patients with asymptomatic severe aortic stenosis and left ventricular myocardial fibrosis (EVOLVED)

30 Oct 2024

Ali Nazmi Calik provides his take on the EVOLVED trial presented by Marc Dweck at TCT 2024 in Washington.

Ali Nazmi Calik

Author

Ali Nazmi Calik
Early intervention in patients with asymptomatic severe aortic stenosis and left ventricular myocardial fibrosis (EVOLVED)

When transfemoral TAVI is not an option: rethinking alternative access strategies

18 Jun 2026

In this article, Ulrich Schäfer explores the evolving landscape of access strategies in transcatheter aortic valve implantation (TAVI). While the transfemoral approach remains the gold standard, a significant proportion of patients are not suitable due to peripheral vascular disease or anatomical constraints.
Drawing on clinical evidence and...

Author

Ulrich Schaefer
Alternative access, if transfemoral is not working
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