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TAV in TAVI with coronary protection - LIVE Case

18 Nov 2025 – From PCR London Valves 2025

Watch a LIVE case followed by a recorded case, regarding a 78-year-old female, with a previous TAVI in 2014 (Sapien 3 26) and sarcoidosis, who presented with symptomatic TAVI stenosis. There was a mis-commissural alignment, with the neoskirt plane above the coronary plane. Under general anesthesia,...

TAV in TAVI with coronary protection -  LIVE Case

Paravalvular leak closure - Part 4

18 Nov 2025 – From PCR London Valves 2025

This session delves into the complexities of paravalvular leak closure with a focus on challenging scenarios including unusual TAVI complications in the mitral position, management of mega paravalvular leaks using jumbo devices, and strategies when closure itself poses an obstacle. It also covers acute peri-operative aortic...

Curious TAVI scenarios - Part 3

18 Nov 2025 – From PCR London Valves 2025

This session examines unusual and challenging clinical scenarios following TAVI, including presentations of cyanosis, evolving valvular defects such as growing paravalvular holes, atypical imaging findings, paradoxical transvalvular gradients switching from aortic regurgitation to stenosis resolved by postdilatation, and bicoronary protection techniques in patients with low coronary...

Featured research - TAVI - Part 14

18 Nov 2025 – From PCR London Valves 2025

This featured research session presents pivotal findings on transcatheter aortic valve implantation (TAVI), including 30-day and one-year outcomes from the VANTAGE trial, novel concepts for assessing aortic stenosis severity, and the influence of mitral annular calcification on conduction disturbances. Additional topics cover the role of clinical...

TAVI - Haemodynamic performance and valve durability

18 Nov 2025 – From PCR London Valves 2025

This session provides an in-depth exploration of haemodynamic performance and valve durability following transcatheter aortic valve implantation (TAVI). Attendees will gain a comprehensive understanding of the differences between invasive and echocardiographic gradients post-TAVI, evaluate the haemodynamic profiles of various transcatheter valve platforms, and appreciate their implications...

TAVI - Haemodynamic performance and valve durability

Complex combined transcatheter interventions

18 Nov 2025 – From PCR London Valves 2025

This session addresses complex combined transcatheter interventions for multivalvular heart disease. It covers integrated transcatheter strategies for multiple valve pathologies, solutions for combined severe aortic stenosis and mitral regurgitation with heavy calcification, and approaches to concomitant atrial functional mitral and tricuspid regurgitation. The session also discusses...

TAVI: complex vascular access - Part 3

18 Nov 2025 – From PCR London Valves 2025

This session focuses on managing complex vascular access challenges in TAVI procedures. It includes case discussions on non-crossable aortic valve stenosis, transseptal TAVI for severe aortic regurgitation with porcelain aorta, and percutaneous implantation in patients with unconventional anatomy or conditions like shaggy syndrome. Strategies for severe...

Complications of paravalvular leak closure

18 Nov 2025 – From PCR London Valves 2025

This session addresses the complexities and risks associated with paravalvular leak (PVL) closure. It offers detailed analysis of principal complications, prevention techniques, and practical management strategies shared by experienced operators. Case studies illustrate complications such as device embolisation, prosthetic valve disc impingement, and delivery failures, along...

SWISS-APERO: a randomized trial of the amulet versus watchman FLX devices for left atrial appendage closure

04 Nov 2021

The SWISS-APERO is a prospective, investigator-initiated, randomized, multi-center, and clinical trial designed to compare the Amulet and Watchman (2.5 and FLX) devices in a head-to-head fashion.

Francesco Costa

Author

Francesco Costa
SWISS-APERO: a randomized trial of the amulet versus watchman FLX devices for left atrial appendage closure

Coronary arteries

30 Oct 2017

The coronary arteries arise from the aortic sinuses. Read more...

 Coronary arteries

The PASCAL IID Registry: A prospective registry for transcatheter edge-to-edge repair in prohibitive risk patients with degenerative mitral regurgitation and complex mitral valve anatomy

17 Sep 2022

Alex Sticchi provides his take on the PASCAL IID Registry and an initial comparison with the CLASP IID. The trial was presented by Jörg Hausleiter during TCT Congress 2022.

Alessandro Sticchi

Author

Alessandro Sticchi
The PASCAL IID Registry: A Prospective Registry for Transcatheter Edge-to-Edge Repair in Prohibitive Risk Patients With Degenerative MR and Complex Mitral Valve Anatomy

CHOICE-CLOSURE: a randomized trial of plug-based versus suture-based large-bore vascular closure

06 Nov 2021

TCT 2021: Radoslaw Parma reviews the CHOICE-CLOSURE multicentre, randomized, controlled, open-label clinical trial presented by Mohamed Abdel-Wahab. The study compared outcomes of percutaneous femoral artery closure using a plug-based and a primary suture-based strategy in patients undergoing TAVI.

Author

Radoslaw Parma
CHOICE-CLOSURE: a randomized trial of plug-based versus suture-based large-bore vascular closure

Meril presents successful LANDMARK RCT one-year results at prestigious EuroPCR 2025

21 May 2025

Best of #AHA21 Scientific Sessions: coronary and valvular heart disease trials

14 Nov 2021

Vijay Kunadian provides summaries of study designs and findings in Interventional Cardiology released at the 2021 virtual edition of the American Heart Association Congress. View an infographic of the AVATAR late-breaking trial by Ali Nazmi Calik.

Vijay Kunadian

Author

Vijay Kunadian
Best of #AHA21 Scientific sessions

A large-scale, randomized trial of orbital atherectomy vs. conventional balloon angioplasty in severely calcified coronary arteries prior to DES implantation (ECLIPSE)

30 Oct 2024

Nicola Ryan provides her take on the ECLIPSE trial presented by Ajay J. Kirtane at TCT 2024 in Washington.

Nicola Ryan

Author

Nicola Ryan
A large-scale, randomized trial of orbital atherectomy vs. conventional balloon angioplasty in severely calcified coronary arteries prior to DES implantation (ECLIPSE)

Percutaneous transseptal transcatheter mitral valve replacement using a dedicated balloon-expandable valve: 1-year outcomes from the ENCIRCLE trial using the SAPIEN M3

27 Oct 2025

Jonathan Curio provides his take on the ENCIRCLE Trial presented by David Daniels at TCT 2025 in San Francisco.

Jonathan Curio

Author

Jonathan Curio
Percutaneous transseptal transcatheter mitral valve replacement using a dedicated balloon expandable valve: 1 year outcomes from the ENCIRCLE trial using the SAPIEN M3

Early intervention in patients with asymptomatic severe aortic stenosis and left ventricular myocardial fibrosis (EVOLVED)

30 Oct 2024

Ali Nazmi Calik provides his take on the EVOLVED trial presented by Marc Dweck at TCT 2024 in Washington.

Author

Ali Nazmi Calik
Early intervention in patients with asymptomatic severe aortic stenosis and left ventricular myocardial fibrosis (EVOLVED)

NOTION-3 - Percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation

01 Sep 2024

Make the most of the insights from Jacob Thomsen Loenborg’s interview with Chiara De Biase and Ali Nazmi Calik’s article to capture the key takeaways from this trial, simultaneously published in the NEJM, presented at the ESC Congress 2024 in London.

Author

Chiara De Biase
Jacob Lønborg

Author

Jacob Lønborg

Author

Ali Nazmi Calik
NOTION 3
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