What are the fundamentals of an upfront two-stent strategy for bifurcation PCI?

Nicola Ryan explores the fundamentals of an upfront two-stent strategy in bifurcation PCI with Dejan Milasinovic. When the side branch shows significant, high-grade stenosis or extensive disease, direct treatment—via POBA, DCB, or a second stent—may be preferred. Anatomy guides the decision between provisional and two-stent strategies, and intracoronary imaging is key, as it helps identify stent distortion or abluminal wiring, as seen in the OCTOBER trial, and ensures optimal rewiring.

Watch the full exchange to refine your approach and improve long-term outcomes in complex bifurcations.

This interview was filmed at EuroPCR 2025: see more videos here.