Nicola Ryan

In-stent restenosis remains the Achilles heel of PCI. Drug-eluting balloons offer a potential strategy for the treatment of in-stent restenosis. To date, implantation of a further drug-eluting stent provide better long-term outcomes compared to paclitaxel drug-eluting balloons.

In this trial, the authors compare the safety and efficacy...

This session offers an in-depth examination of potential complications during routine primary PCI, focusing on prevention and management strategies. Key learning points include understanding no-reflow phenomena, managing STEMI in post-CABG patients, and handling thrombus burden effectively. Real-world cases illustrate decision-making processes and therapeutic approaches to optimize...

This session presents new data on intracoronary imaging-guided interventions, comparing outcomes of angiography-derived FFR and IVUS-guided PCI over two years, as well as OCT versus IVUS for intermediate left main stenosis. It further evaluates high-risk non-culprit lesions post-myocardial infarction, the role of coronary lipid burden in...

Nicola Ryan provides her take on the 10-year follow-up of the HOST-EXAM, which was presented by Hyo-Soo Kim at ACC.26 in New Orleans.

The TICO1 and T-PASS2 trials evaluated abbreviated DAPT followed by ticagrelor monotherapy compared to DAPT in patients with ACS undergoing PCI. Both trials demonstrated the safety and efficacy of abbreviated DAPT however, the optimal timing of aspirin discontinuation remains uncertain. This post hoc analysis compares the...

Nicola Ryan provides her take on DKCRUSH-VIII, a randomised controlled trial comparing IVUS versus angiography guidance for PCI, predominantly using the DKCRUSH technique in patients with complex bifurcation lesions, as presented by Shaoliang Chen at ACC.26 in New Orleans.

Nicola Ryan provides her take on the trial evaluating multi-modality imaging to determine underlying causes of MINOCA in women and men. The trial results were presented by Harmony R. Reynolds at ACC.26 in New Orleans and simultaneously published in Circulation.

Live updates on a selection of major Late Breaking Clinical Trials of interest in interventional cardiology presented at the American College of Cardiology 2026 Scientific Sessions #ACC26

In patients with severely calcified coronary lesions undergoing PCI, the BALI trial evaluated the benefit of the addition of intravascular lithotripsy to conventional lesion preparation on the composite endpoint of procedural failure and target vessel failure.

While FFR traditionally reflects the severity of a lesion at a fixed location, PPG incorporates the pullback profile, enabling a more comprehensive understanding of disease distribution.

This individual patient data analysis of the three largest RCTs evaluating IVUS-guided stent optimisation showed that an MSA > 5.5 mm2 was associated with reduced TVF at one year. 

Nicola Ryan provides her take on the PROMISE trial presented by Rocco Antonio Montone at TCT 2025, in San Francisco.

Thanks to the contribution of a team of interventional cardiologists from around the globe, get the international perspective on Late-breaking Clinical Trials and Science released at TCT 2025 - check out the list below.

Nicola Ryan provides her take on the results of TAILORED-CHIP presented by Duk-Woo Park at the ESC Congress 2025 in Madrid.

Stay updated with the latest in interventional cardiology at #ESCCongress 2025!

This analysis from the XIENCE Short DAPT programme compared the safety and efficacy of one-month versus three-month DAPT in high-bleeding risk patients with and without diabetes mellitus (DM) following PCI with everolimus eluting stents (EES).

This prespecified analysis of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME 3) trial examined the impact on cardiovascular outcomes of treatment by CABG versus FFR-guided PCI in patients with three vessel disease (3-VD), stratified by acute (NSTEMI) or chronic coronary syndrome (CCS) presentation.

This exploratory analysis from the MASTER DAPT trial evaluates the effect of abbreviated versus prolonged DAPT on total ischaemic and bleeding events in high-bleeding-risk patients from the MASTER DAPT trial.

This large retrospective analysis using data from the Republic of Korea’s Nationwide Health Claims database showed that co-prescription of a PPI in patients treated with DAPT following an AMI was associated with reduced major GI bleeding as well as reduced minor GI bleeding requiring hospitalisation, regardless...

An 87-year-old female patient, at high bleeding risk and with preserved LV function, presented 2 months ago with an inferior STEMI and multivessel disease. She initially underwent RCA PCI followed by staged LCx PCI. She was now referred for PCI of a long, heavily calcified lesion...

This session addresses the management of high thrombus burden in STEMI patients. It reviews available tools and strategies for thrombus management, presents multiple case-based discussions illustrating treatment decisions, and explores the evolving role of thrombus aspiration in contemporary practice.

Examine coronary stent loss complications and retrieval techniques in this session. Review innovative approaches such as retrieval of dislodged stents from unusual locations like the renal artery, and discussions on navigating stent-related struggles, including the mechanical journey and consequences of stent loss during PCI.

This session highlights the power of multimodality imaging and physiology in diagnosing MINOCA. Topics include detecting hidden plaque vulnerability, managing unexpected diagnoses beyond MINOCA, decision-making on stenting, AI's added value, and lessons from recurrent cases.

Nicola Ryan and Flavio Ribichini explore the complexities of calcified left main stem disease, emphasizing the critical role of intracoronary imaging in improving patient outcomes. They discuss the practical use of mechanical circulatory support and debate stenting strategies, offering expert insights on when single or dual...

Nicola Ryan explores the fundamentals of an upfront two-stent strategy in bifurcation PCI with Dejan Milasinovic. When the side branch shows significant, high-grade stenosis or extensive disease, direct treatment - via POBA, DCB, or a second stent - may be preferred. Anatomy guides the decision between...

Nicola Ryan provides her take on the WARRIOR trial which was presented by Eileen Handberg at ACC.25 in Chicago.

The manuscript for this trial has not been published and all assumptions are based upon the presentation.

The authors hypothesized that enriching invasive coronary angiography (ICA) with an advanced invasive diagnosis (AID) strategy would increase the diagnostic yield of obstructive and non-obstructive coronary artery disease (INOCA).

Live updates on a selection of major Late Breaking Clinical Trials of interest in interventional cardiology presented at the American College of Cardiology 2025 Scientific Sessions #ACC25

NIRS-IVUS offers precise assessment of coronary artery pathology but is invasive and limited in scope, while CCTA is emerging as a non-invasive alternative for comprehensive plaque evaluation.

The AD-HOC Registry aimed to evaluate procedural success and clinical outcomes of current-generation BEVs and SEVs in treating stenotic Sievers type 1 BAV.