NSTEMI (Non-ST-segment elevation myocardial infarction)

Find all the latest content on NSTEMI published on this website.

NSTEMI is considered one of the leading causes of morbidity and mortality and its definition and treatment remains challenging requiring specific, adapted responses. Understanding different biomarkers, becoming aware of emerging new agents used in adjunctive pharmacotherapy, keeping abreast of advances in imaging techniques as well as the use of invasive imaging and functional assessment is critical. Tools, devices and techniques, and complications such as different types of vascular access or bleeding risks, can also be found here…

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NSTEMI

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Managing ischaemic and bleeding risk of NSTEMI patients

22 May 2025 – From EuroPCR 2025

Gain valuable insights into managing ischemic and bleeding risks in NSTEMI patients. This session reviews optimal timing for invasive strategies, variability in care processes, radial access approaches, and innovative antithrombotic strategies such as aspirin omission and prasugrel monotherapy to minimize bleeding while optimizing outcomes.

Managing ischaemic and bleeding risk of NSTEMI patients

Risk stratification of NSTEMI patients

22 May 2025 – From EuroPCR 2025

Explore the latest insights on risk stratification in NSTEMI patients through comparative analysis of established risk scores such as GRACE, HEART, and TIMI in predicting coronary artery disease severity. This session also reviews outcomes based on diabetes status and left ventricular ejection fraction, prospective validation of...

Risk stratification of NSTEMI patients

Spotlight on major Late-Breaking Trials presented at EuroPCR 2025

21 May 2025

These trials were selected because of their design, results, and potential to impact practice: Discover the key findings of the 4D-ACS and FAITAVI randomised clinical trials and a meta-analysis of PROTECTED TAVR and BHF PROTECT TAVI.

Selection of top Late-breaking Trials presented at #EuroPCR

Complications management in NSTEMI patients

21 May 2025 – From EuroPCR 2025

Explore effective management strategies for complications in NSTEMI patients through real-life complex cases. Topics include saphenous vein graft stenting challenges, dislodged stents, rare coronary bifurcation perforations, and solutions for graft blockage with covered stents.

Complications management in NSTEMI patients

How to deal with left main culprit in NSTEMI

21 May 2025 – From EuroPCR 2025

This session offers a cross-geographic exchange on managing left main culprit lesions in NSTEMI patients. Learn different interventional approaches, risk evaluation for periprocedural complications, and diverse PCI management strategies tailored to this complex subgroup.

How to deal with left main culprit in NSTEMI

Improving outcomes of NSTEMI patients

21 May 2025 – From EuroPCR 2025

Review contemporary evidence on improving outcomes for NSTEMI patients. Topics include the effects of evolocumab on stent coverage, impact of left ventricular function with kidney disease, GRACE score-based outcomes, PCI timing, and early initiation of Tafolecimab.

Improving outcomes of NSTEMI patients

Imaging-guided management of PCI pitfalls in NSTEMI

21 May 2025 – From EuroPCR 2025

Dive into the imaging-guided management of PCI pitfalls in NSTEMI patients. This session highlights critical cases such as complications from missed PCI, crushed stents, multiple coronary lumens, and migrating thrombus, emphasizing the role of advanced intracoronary imaging for precise diagnosis and optimized interventional outcomes.

Imaging-guided management of PCI pitfalls in NSTEMI

Overcoming resistant lesions in NSTEMI

21 May 2025 – From EuroPCR 2025

Address the challenges of resistant lesions in NSTEMI with this focused session. Learn from complex cases involving thrombus management using Penumbra systems and Guideliner, as well as strategies to overcome extensive calcification through multiple interventional tools, illustrating a stepwise approach to tackling difficult coronary lesions.

Overcoming resistant lesions in NSTEMI

EuroPCR 2025 – One-month dual antiplatelet therapy followed by prasugrel monotherapy at a reduced dose: the 4D-ACS randomised trial

21 May 2025

Paris, France, 20-23 May 2025. The EuroPCR Course Directors have selected 3 major late-breaking trials that will be presented for the first time during the 2025 edition of EuroPCR. These trials were selected because of their design, results, and potential to impact practice, among them is the...

EuroPCR 2025 – One-month dual antiplatelet therapy followed by prasugrel monotherapy at a reduced dose: the 4D-ACS randomised trial

PCR's Got Talent Round 1 - Session 1

20 May 2025 – From EuroPCR 2025

Experience a diverse range of cutting-edge interventional cardiology topics in PCR's Got Talent Round 1. This session features presentations on PFO closure outcomes, plaque morphology, vascular injury treatments, microvascular disease assessment, TAVI-related coronary obstruction prediction, novel FFR surrogates, and more.

PCR's Got Talent Round 1 - Session 1

Role of imaging in ACS: from non-invasive to invasive investigations

20 May 2025 – From EuroPCR 2025

Explore the critical role of imaging in acute coronary syndrome (ACS) from non-invasive coronary CT angiography to invasive intracoronary imaging modalities. This session covers detection of culprit lesions, diagnostic strategies, and PCI optimization through real-world case examples.

Role of imaging in ACS: from non-invasive to invasive investigations

Multimodality imaging and physiology for MINOCA diagnosis

20 May 2025 – From EuroPCR 2025

This session highlights the power of multimodality imaging and physiology in diagnosing MINOCA. Topics include detecting hidden plaque vulnerability, managing unexpected diagnoses beyond MINOCA, decision-making on stenting, AI's added value, and lessons from recurrent cases.

Multimodality imaging and physiology for MINOCA diagnosis

Strategic decision in stent failure

20 May 2025 – From EuroPCR 2025

Explore strategic decision-making in cases of stent failure in this session presenting complex clinical scenarios. Through detailed case analyses, including challenging left main trifurcation lesions and NSTEMI in the presence of chronic total occlusions, discover treatment approaches and key learnings to optimize patient outcomes.

Strategic decision in stent failure

Difficult ACS case management and complication

20 May 2025 – From EuroPCR 2025

Learn expert strategies for managing challenging acute coronary syndrome (ACS) cases and complications. This session covers balloon-uncrossable CTO management in high-risk NSTEMI, iatrogenic coronary perforation during STEMI, spontaneous coronary artery dissection, and complex anterior STEMI interventions with key clinical learnings.

Difficult ACS case management and complication

PCR's Got Talent Round 1 - Session 2

20 May 2025 – From EuroPCR 2025

Join the dynamic PCR's Got Talent Round 1 - Session 2 featuring cutting-edge research and innovations in interventional cardiology. Highlights include complex CTO PCI strategies, valve comparisons in TAVI for small annuli, PFO closure outcomes, long-term PCI durability, CT-guided robotic PCI, pacemaker prediction post-TAVI, and much...

PCR's Got Talent Round 1 - Session 2

Rotational atherectomy, lithotripsy, or laser for calcified coronary stenosis: the ROLLER COASTR-EPIC22 trial

24 Mar 2025

Due to a lack of randomised evidence, this randomised controlled trial (RCT) aimed to compare the safety and efficacy of IVL and ELCA with RA in treating heavily calcified coronary lesions before drug-eluting stent implantation.

Reviewer

Ali Nazmi Calik

Reviewer

Aaysha Cader
Rotational atherectomy, lithotripsy, or laser for calcified coronary stenosis: the ROLLER COASTR-EPIC22 trial

Usefulness of FFR-CT to exclude haemodynamically significant lesions in high-risk NSTE-ACS

07 Mar 2025

This single-arm, double-blinded, core-laboratory adjudicated, prospective trial, conducted across four European centers between August 2019 and April 2022, investigates whether CCTA and FFR-CT are able to exclude hemodynamically significant coronary stenoses in patients with high-risk NSTE-ACS.

Reviewer

Ali Nazmi Calik

Reviewer

Murat Gökalp
Usefulness of FFR-CT to exclude haemodynamically significant lesions in high-risk NSTE-ACS

Functional or anatomical assessment of non-culprit lesions in acute myocardial infarction

06 Mar 2025

This study demonstrates that OCT-defined TCFA is a superior prognostic marker compared to μQFR for assessing NCLs in AMI patients.

Alessandro Sticchi

Reviewer

Alessandro Sticchi
Functional or anatomical assessment of non-culprit lesions in AMI

How should I treat a left main disease with multivessel diffuse CAD? Stenting only the necessary...

28 Feb 2025

A 71-year-old male patient with a clinicial history of hypertension, dyslipidemia and active smoking was admitted for NSTEMI.

Coronary angiography showed a left main (LM) stenosis involving the bifurcation and proximal parts of the left anterior descending (LAD) and left circumflex (LCx) arteries. Right coronary artery (RCA) showed a severe...

Eva Rumiz

Author

Eva Rumiz
How should I treat a left main disease with multivessel diffuse CAD? Stenting only the necessary

Comprehensive diagnosis in chronic coronary syndromes combining angiography and intracoronary testing: the AID-ANGIO study

18 Feb 2025

The authors hypothesized that enriching invasive coronary angiography (ICA) with an advanced invasive diagnosis (AID) strategy would increase the diagnostic yield of obstructive and non-obstructive coronary artery disease (INOCA).

Ruxandra Sava

Reviewer

Ruxandra Sava
Nicola Ryan

Reviewer

Nicola Ryan
Comprehensive diagnosis in CCS combining angiography and intracoronary testing AID-ANGIO study