NSTEMI (Non-ST-segment elevation myocardial infarction)

Latest NSTEMI content in interventional cardiology - research, practice, and education

NSTEMI is considered one of the leading causes of morbidity and mortality and its definition and treatment remains challenging requiring specific, adapted responses. Understanding different biomarkers, becoming aware of emerging new agents used in adjunctive pharmacotherapy, keeping abreast of advances in imaging techniques as well as the use of invasive imaging and functional assessment is critical. Tools, devices and techniques, and complications such as different types of vascular access or bleeding risks, can also be found here…

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NSTEMI

259 results

Modern approach to tackle rocky roads

02 Jun 2026

Complex PCI of a calcified vessel in a 72-year-old gentleman with NSTEACS and markedly reduced LV function.

This case highlights how to tackle a challenging access and a difficult coronary lesion in a patient with scarce hemodynamic reserve.

Author

Ivan Vosko

Author

Otar Kvavadze

Author

Gabor G Toth
 Modern approach to tackle rocky roads

Clinical decision making for CTO PCI strategy

22 May 2026 – From EuroPCR 2026

This session explores clinical decision-making in CTO PCI strategy through complex scenarios including multivessel CTO in ischemic cardiomyopathy, high-risk NSTEMI post-vein graft failure, and challenges in elderly patients. It emphasizes strategic planning and individualized approaches to optimize outcomes.

Atypical NSTEMI culprit lesions

22 May 2026 – From EuroPCR 2026

Focusing on atypical NSTEMI culprit lesions, this session examines rare presentations such as calcific emboli, coronary anomalies, and unusual routes to revascularisation. It provides clinical insights into diagnosing and managing uncommon acute coronary syndromes effectively.

NSTEMI: when everything does not go as planned

21 May 2026 – From EuroPCR 2026

This session presents complex cases of NSTEMI where unexpected challenges arise during intervention. It provides a comprehensive review of complication management strategies, including coronary perforation techniques. Through detailed case analyses from diverse centers, attendees gain practical insights into troubleshooting and treatment adaptations essential for managing difficult...

Refining management of NSTEMI

21 May 2026 – From EuroPCR 2026

This session refines NSTEMI management by exploring advanced diagnostic tools, risk stratification, and tailored revascularization strategies, including bleeding risk assessment and dual antiplatelet therapy considerations.

All you need to know of DAPT in ACS

21 May 2026 – From EuroPCR 2026

This session provides an in-depth review of dual antiplatelet therapy (DAPT) in acute coronary syndrome (ACS), focusing on strategies for safe de-escalation and P2Y12 inhibitor monotherapy to reduce bleeding risk without compromising ischemic protection. It also covers optimizing antithrombotic therapy in patients on oral anticoagulation and...

Various NSTEMI cases

21 May 2026 – From EuroPCR 2026

This session presents diverse NSTEMI case studies addressing complex diagnostic and interventional challenges, including coronary dissections, intramural hematomas, ischemic complications, and functional lesion assessment.

Complication two: PCI complications occurring during PCI for NSTEMI

21 May 2026 – From EuroPCR 2026

This session addresses the spectrum of PCI complications encountered during NSTEMI interventions, including coronary perforations, challenges with unexpanded covered stents, IVUS-related issues, giant coronary aneurysms at bifurcations, and distal wire perforations, providing critical lessons in complication management and operator coordination.

Innovative strategy in ACS

20 May 2026 – From EuroPCR 2026

Focusing on innovative strategies in acute coronary syndrome (ACS), this session reviews recent advances including drug-coated balloons in STEMI, early discharge safety guided by microcirculatory resistance indices, intravascular lithotripsy for coronary calcification in ACS, and novel stenting protocols demonstrated in randomized trials, providing a comprehensive update...

Complication one: PCI complications occuring during urgent PCI for NSTEMI

20 May 2026 – From EuroPCR 2026

Examine real-world PCI complications encountered during urgent interventions for NSTEMI patients. This session presents a series of complex cases illustrating management strategies for adverse events such as coronary perforations, device issues, and imaging challenges to inform safer procedural practice.

Typical chest pain: atypical angiogram

20 May 2026 – From EuroPCR 2026

This session addresses the management challenges posed by acute coronary syndromes when angiographic findings are ambiguous or atypical. It highlights the role of intravascular imaging in clarifying diagnoses and discusses recent insights from clinical cases and key studies such as DISCO and the latest NSTEMI EuroIntervention...

Complex patients with NSTEMI

20 May 2026 – From EuroPCR 2026

This session addresses the complexity of managing NSTEMI patients with challenging clinical presentations, including concurrent vessel and valve disease, thrombus burden, and atypical angiographic findings. It offers practical strategies for diagnosis and intervention to optimize patient outcomes.

All we need to know about vulnerable plaque

19 May 2026 – From EuroPCR 2026

Understand the critical importance of vulnerable plaque identification and management. This session covers optimal strategies for detecting vulnerable plaques, their prognostic implications, and evidence-based treatment approaches illustrated through detailed case presentations.

Complex PCI in patients with acute coronary syndrome

19 May 2026 – From EuroPCR 2026

Explore complex PCI management in acute coronary syndrome patients through detailed case presentations illustrating complication handling and bailout techniques. Learn from challenging scenarios including graft perforation, no-flow situations, guidewire dissections, and stent dislodgement, emphasizing preparedness and strategic responses to improve clinical outcomes in high-risk interventions.

Unusual NSTEMI lesions and cases

19 May 2026 – From EuroPCR 2026

This session presents a collection of unusual NSTEMI cases characterized by atypical lesion patterns and diagnostic challenges. Topics include surprising unstable angina presentations, complex ostial lesions of the left circumflex artery, and the critical role of OCT imaging in preventing adverse outcomes.

NOBLE trial: 10-year outcomes of PCI vs CABG in left main disease

13 Apr 2026

Long-term evidence comparing PCI and CABG for unprotected left main coronary disease has been limited and sometimes conflicting. The 10-year results from the NOBLE trial now provide important clarity on all-cause mortality outcomes with both revascularisation strategies.

Ruxandra Sava

Reviewer

Ruxandra Sava
PCI vs CABG in left main disease: 10-year NOBLE results

Intravascular imaging vs angiography guided complex PCI: 5-year outcomes from a randomised trial

13 Apr 2026

The RENOVATE-COMPLEX-PCI 5-year outcomes confirm the long-term durability of benefits seen with intracoronary imaging over angiography guided PCI in complex lesions.

Angela McInerney

Reviewer

Angela McInerney

Reviewer

Nieves Gonzalo
Intravascular imaging vs angiography guided complex PCI: the RENOVATE-COMPLEX-PCI 5 year outcomes

Coronary calcification versus thrombus: a deceptive ambiguity revealed in the aftermath of embolisation

07 Apr 2026

Discriminating between coronary calcification and thrombus in acute settings remains a diagnostic challenge with significant implications for interventional decision-making.

Imran Hanif Hashmi

Author

Imran Hanif Hashmi
Minahil Tariq Sheikh

Author

Minahil Tariq Sheikh
Ahmad Usama Wali

Author

Ahmad Usama Wali
Coronary calcification versus thrombus: a deceptive ambiguity revealed in the aftermath of embolisation

Aspirin discontinuation timing with ticagrelor monotherapy in ACS: a post hoc analysis from TICO and T-PASS

11 Mar 2026

The TICO1 and T-PASS2 trials evaluated abbreviated DAPT followed by ticagrelor monotherapy compared to DAPT in patients with ACS undergoing PCI. Both trials demonstrated the safety and efficacy of abbreviated DAPT however, the optimal timing of aspirin discontinuation remains uncertain. This post hoc analysis compares the...

Nicola Ryan

Reviewer

Nicola Ryan
Optimal timing of aspirin discontinuation with ticagrelor monotherapy in ACS: insights from TICO and T-PASS

Ticagrelor vs prasugrel in patients with diabetes and multivessel coronary artery disease: the TUXEDO-2 randomised clinical trial

17 Feb 2026

The TUXEDO-2 trial sought to directly compare prasugrel versus ticagrelor in diabetic patients undergoing percutaneous coronary intervention (PCI), with the aim of clarifying whether the non-inferiority of ticagrelor could be established.

Raffaele Piccolo

Reviewer

Raffaele Piccolo
TUXEDO-2 ticagrelor vs prasugrel in patients with diabetes and MVD CAD