NSTEMI (Non-ST-segment elevation myocardial infarction)

Find all the latest content on NSTEMI published on this website.

NSTEMI is considered one of the leading causes of morbidity and mortality and its definition and treatment remains challenging requiring specific, adapted responses. Understanding different biomarkers, becoming aware of emerging new agents used in adjunctive pharmacotherapy, keeping abreast of advances in imaging techniques as well as the use of invasive imaging and functional assessment is critical. Tools, devices and techniques, and complications such as different types of vascular access or bleeding risks, can also be found here…

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NSTEMI

293 results

Ten trials from AHA 2025

12 Nov 2025

Alessandro Sticchi provides us with a curated overview of the late-breaking trials he found most relevant for interventional cardiologists from AHA 2025.

Alessandro Sticchi

Author

Alessandro Sticchi
Ten trials from AHA 2025

Renal, inflammation and protection strategies in PCI

11 Oct 2025 – From AICT-AsiaPCR 2025

Delve into renal protection and inflammation management strategies in PCI, with a focus on renal blood flow indicators in chronic heart failure, the protective role of exosomes in myocardial ischemia, and efficacy of renal guard devices against contrast-induced nephropathy. The session also examines radial artery occlusion...

STEMI, thrombus and emergencies

10 Oct 2025 – From AICT-AsiaPCR 2025

Focused on STEMI and acute thrombotic emergencies, this session presents a series of challenging cases involving heavy thrombus burden, acute total occlusions, and complex primary angioplasty scenarios. It explores innovative approaches beyond stenting, the role of drug-coated balloons in plaque erosion, and strategic decision-making in managing...

Complex coronary challenges and anomalies

10 Oct 2025 – From AICT-AsiaPCR 2025

This session explores complex coronary challenges and anatomical anomalies encountered in clinical practice. Topics include management of thrombus showers from unexpected culprits, ultra-low contrast angioplasty in mesenteric ischemia, advanced bifurcation PCI techniques with IVUS guidance, and troubleshooting difficult stent delivery scenarios in calcified lesions and challenging...

Coronary interventions: access, devices and outcomes

10 Oct 2025 – From AICT-AsiaPCR 2025

This session delves into the latest developments in coronary interventions, highlighting advances in vascular access techniques, innovative devices, and clinical outcomes. Topics include endothelial progenitor cell dysfunction in restenosis, the efficacy of distal radial artery (DRA) puncture and sheathless catheters in underserved areas, the use of...

NSTEMI, complex ACS and anatomy

10 Oct 2025 – From AICT-AsiaPCR 2025

This session focuses on complex cases involving non-ST elevation myocardial infarction (NSTEMI), acute coronary syndromes (ACS), and challenging coronary anatomy. It presents unique clinical scenarios such as pediatric rescue PCI, management of significant distal lesions with proximal PCI, anatomical variations complicating interventions, mixed cardiovascular disease management,...

Calcium nodule in circumflex ostium: a complex problem

31 Oct 2025

Analyse this case of an 83-year-old male patient, hypertensive, ex-smoker, with severe COPD and peripheral arterial disease with unstable angina. Coronary angiography revealed a severely calcified lesion in a complex anatomical area, making revascularisation a therapeutic challenge.

Jorge Perea

Author

Jorge Perea
Javier Suarez de Lezo

Author

Javier Suarez de Lezo
Soledad Ojeda

Author

Soledad Ojeda
Prof. Manuel Pan

Author

Manuel Pan
Calcium nodule in circumflex ostium: a complex problem

DAPT-SHOCK-AMI trial: Cangrelor in cardiogenic shock

03 Sep 2025

Kalaivani Mahadevan and Fizzah Choudry provide their take on DAPT-SHOCK-MI presented by Zuzana Motovska at ESC Congress 2025 in Madrid.

Fizzah Choudry

Author

Fizzah Choudry
Kalaivani Mahadevan

Author

Kalaivani Mahadevan
DAPT-SHOCK-AMI trial: Cangrelor in cardiogenic shock

Optical coherence tomography- vs angiography-guided coronary stent implantation in calcified lesions: the ILUMIEN IV trial

28 Aug 2025

In the overall population (n = 2,114), there was a significant interaction between the effect of randomisation to OCT guidance vs angiography guidance in lesions with moderate/severe calcification (n = 1,082) vs no/mild calcification (n = 1,032) on the 2-year rate of TVF (Pinteraction = 0.01).

Reviewer

Salvatore Brugaletta
OCT- vs angiography-guided coronary stent implantation in calcified lesions: the ILUMIEN IV trial

TACSI: Dual or single antiplatelet therapy after CABG in patients with acute coronary syndrome

03 Sep 2025

Aaysha Cader provides her take on TACSI presented by Anders Jeppsson at ESC Congress 2025 in Madrid.

Author

Aaysha Cader
TACSI: Dual or single antiplatelet therapy after CABG in patients with acute coronary syndrome

NEO-MINDSET: Early withdrawal of aspirin after percutaneous coronary intervention for acute coronary syndrome

02 Sep 2025

Daniele Giacoppo reports and provides his perspective on the main results of the ambitious NEOMINDSET trial, presented by Pedro Lemos from the Hospital Israelita Albert Einstein, São Paulo, Brazil, during a Late Breaking Trials session at the ESC Congress 2025 in Madrid, and simultaneously published in the New...

Daniele Giacoppo

Author

Daniele Giacoppo
NEO-MINDSET: Early withdrawal of aspirin after percutaneous coronary intervention for acute coronary syndrome

Duration of DAPT in ACS: The DUAL-ACS Trial

31 Aug 2025

Ali Nazmi Calik interviews David Newby on the landmark DUAL-ACS trial results he presented at ESC Congress 2025 in Madrid.

The trial compared 3 months versus 12 months of dual antiplatelet therapy (DAPT) after myocardial infarction in an all-comer population. Findings suggest that shorter therapy may offer better...

Author

Ali Nazmi Calik
David Newby

Author

David Newby
The DUAL-ACS Trial:

One- versus three-month DAPT after everolimus-eluting stent implantation in diabetic patients at high-bleeding risk: results from the XIENCE Short DAPT programme

17 Jun 2025

This analysis from the XIENCE Short DAPT programme compared the safety and efficacy of one-month versus three-month DAPT in high-bleeding risk patients with and without diabetes mellitus (DM) following PCI with everolimus eluting stents (EES).

Nicola Ryan

Reviewer

Nicola Ryan
1- versus 3-month DAPT after EES implantation in HBR diabetic patients: results from the XIENCE Short DAPT programme

Outcomes after CABG compared with FFR-guided PCI in patients presenting with acute coronary syndrome

10 Jun 2025

This prespecified analysis of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME 3) trial examined the impact on cardiovascular outcomes of treatment by CABG versus FFR-guided PCI in patients with three vessel disease (3-VD), stratified by acute (NSTEMI) or chronic coronary syndrome (CCS) presentation.

Ruxandra Sava

Reviewer

Ruxandra Sava
Nicola Ryan

Reviewer

Nicola Ryan
Outcomes after CABG compared with FFR-guided PCI in patients presenting with ACS

Recurrent events analysis of MASTER DAPT: total ischemic and bleeding events after abbreviated vs prolonged DAPT in HBR patient

04 Jun 2025

This exploratory analysis from the MASTER DAPT trial evaluates the effect of abbreviated versus prolonged DAPT on total ischaemic and bleeding events in high-bleeding-risk patients from the MASTER DAPT trial.

Nicola Ryan

Reviewer

Nicola Ryan
Recurrent events analysis of MASTER DAPT: total ischemic and bleeding events after abbreviated vs prolonged DAPT in HBR patient

Overcoming complex anatomy in NSTEMI

23 May 2025 – From EuroPCR 2025

Explore advanced interventional strategies addressing complex anatomy in NSTEMI patients. This session presents challenging cases including unusual STEMI presentations with cardiogenic shock in Takayasu arteritis, subtotal aorto-ostial lesions in young patients, and management of giant coronary artery aneurysms, emphasizing tailored approaches to optimize outcomes.

Overcoming complex anatomy in NSTEMI

How coronary physiology may help in guiding treatment of NSTEMI

23 May 2025 – From EuroPCR 2025

This session explores the utility of coronary physiology in guiding NSTEMI treatment. Topics include ischemia with non-obstructive arteries, QFR quality assessment, FFR-CT impact, revascularization deferral, and sex differences in FFR-guided strategies for acute myocardial infarction with multivessel disease.

How coronary physiology may help in guiding treatment of NSTEMI

Calcified un-dilatable lesions in ACS: what should I do?

22 May 2025 – From EuroPCR 2025

Address the challenges of severely calcified undilatable lesions during acute coronary syndrome PCI. This session reviews the impact of coronary calcification on PCI strategy, highlights pitfalls in lesion preparation, and presents detailed case studies demonstrating effective treatment approaches.

Calcified un-dilatable lesions in ACS: what should I do?

Bifurcation CAD: presentation and PCI strategies

22 May 2025 – From EuroPCR 2025

Navigate the complexities of coronary bifurcation disease with a comprehensive session covering decision-making, imaging applications, and PCI strategies. Review clinical scenarios involving left main disease, calcifications, and acute presentations. Understand the pivotal role of intracoronary imaging and explore provisional and two-stent techniques through detailed case discussions...

Bifurcation CAD: presentation and PCI strategies

Challenging left main PCI in NSTEMI patients

22 May 2025 – From EuroPCR 2025

Address the complexities of left main PCI in NSTEMI patients with challenging clinical presentations. This session discusses management of complex left main bifurcation disease, early graft failure guided by imaging and physiology, revascularization strategies for coronary left main occlusion, PCI complications requiring CTO techniques, and acute...

Challenging left main PCI in NSTEMI patients