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Mitral valve replacement and repair

Find all the latest content on mitral valve replacement and repair published on this website.

Building on the years of experience with TAVI, mitral valve replacement and repair is now beginning to take-off with a vast array of new techniques and options. Certain devices, for instance in mitral repair, are now widely used. To understand this complex field a knowledge and mastery is required covering the latest research, emerging tools, devices and techniques, vascular access; the role of adjunctive pharmacotherapy; imaging techniques such as echocardiography as well as understanding bleeding risks or patient selection. Find out more…

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Mitral valve replacement and repair

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Early Career Research Award Final

17 Nov 2025 – From PCR London Valves 2025

Highlighting pioneering research in structural heart interventions, this session presents studies on the impact of transcatheter tricuspid valve replacement (TTVR) on left ventricular geometry and function, myocardial remodeling in aortic stenosis, physiological responses after mitral and tricuspid edge-to-edge repairs, advancing the understanding of device effects on...

Percutaneous mitral balloon commissurotomy in unusual scenarios

17 Nov 2025 – From PCR London Valves 2025

This session examines percutaneous mitral balloon commissurotomy applied in unusual and challenging scenarios. It covers advanced techniques such as wire-guided Inoue balloon valvuloplasty post annuloplasty, strategies for severe mitral calcification, and innovative simplifications of established methods, emphasizing the ongoing relevance of this procedure in complex mitral...

Challenging transcatheter mitral valve replacement

17 Nov 2025 – From PCR London Valves 2025

Explore the complexities of transcatheter mitral valve replacement (TMVR) with discussions on managing mitral annular calcification, preventing paravalvular leaks in mitral valve-in-ring procedures, strategies for larger valve deployment in large mitral rings, and the evolution of transseptal TMVR providing durable relief for previously untreatable cases.

Transcatheter solutions in young and congenital heart disease patients

17 Nov 2025 – From PCR London Valves 2025

This session focuses on transcatheter solutions tailored for young and congenital heart disease patients, featuring challenging edge-to-edge repair in extracardiac Fontan physiology, systemic AV valve TEER in congenital anomalies, multidisciplinary management of repaired tetralogy of Fallot with tricuspid regurgitation, innovative TAVI in young congenital patients, and...

What are the key considerations for transcatheter mitral paravalvular leak management?

18 Nov 2025 – From PCR London Valves 2025

Nina Wunderlich and Patrick Calvert discuss mitral paravalvular leaks, which are relatively common. Percutaneous closure is now the default approach, and imaging is central to success: detailed pre-procedural assessment, 3D TOE during the procedure, and careful planning of transseptal puncture. 

This interview was filmed at PCR London...

What are the key considerations for transcatheter mitral paravalvular leak management?

TAVI for aortic regurgitation in high surgical risk: outcomes in 700 patients from ALIGN-AR

16 Nov 2025 – From PCR London Valves 2025

Christopher Allen and Raj Makkar sit down to review the ALIGN-AR trial and its implications for treating native aortic regurgitation. 

ALIGN-AR was a pivotal, single-arm, multicenter investigational study designed to evaluate a dedicated transcatheter solution in patients with moderate-to-severe native AR who were considered high risk for...

Outcomes in 700 patients from ALIGN-AR regarding TAVI for AR in high surgical risk

Is iatrogenic atrial septum defect closure a necessary procedure?

17 Nov 2025 – From PCR London Valves 2025

Philipp Lurz and Saibal Kar discuss iatrogenic atrial septal defects from transseptal procedures. Small ones usually close on their own, while large defects causing significant shunting need closure to prevent right heart overload. Some moderate defects may be beneficial by decompressing the left atrium, so closure...

Is iatrogenic atrial septum defect closure a necessary procedure?

What are the key considerations when managing combined mitral and tricuspid regurgitation?

17 Nov 2025 – From PCR London Valves 2025

Fabien Praz and Neil Fam talk about the management of patients with combined mitral and tricuspid regurgitation, who are often elderly with heart failure and multiple comorbidities. Careful assessment—including echocardiography, hemodynamics, and sometimes CT—is crucial to identify the dominant lesion. Surgery is preferred if feasible, but...

What are the key considerations when managing combined mitral and tricuspid regurgitation?

How do we meet the needs of women with heart valve disease?

17 Nov 2025 – From PCR London Valves 2025

In this interview, Ellen Ross and Marta Sitges discuss a recent initiative from Global Heart Hub - a patient association - which examined the realities faced by women living with heart valve disease. They outline the gaps identified, the call to action that followed, and how...

How do we meet the needs of women with heart valve disease?

How are the new ESC/EACTS valvular guidelines going to impact my mitral programme?

17 Nov 2025 – From PCR London Valves 2025

Francesco Maisano interviews Michael Borger, co-chair of the 2025 ESC/EACS valvular heart disease guidelines, on their practical impact. The updated guidelines emphasize earlier intervention in primary mitral regurgitation, especially for asymptomatic patients with risk factors, while surgery remains preferred for low-risk patients. Michael Borger stresses the...

How are the 2025 ESC/EACTS valvular guidelines going to impact my mitral programme?