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Mitral valve replacement and repair

Find all the latest content on mitral valve replacement and repair published on this website.

Building on the years of experience with TAVI, mitral valve replacement and repair is now beginning to take-off with a vast array of new techniques and options. Certain devices, for instance in mitral repair, are now widely used. To understand this complex field a knowledge and mastery is required covering the latest research, emerging tools, devices and techniques, vascular access; the role of adjunctive pharmacotherapy; imaging techniques such as echocardiography as well as understanding bleeding risks or patient selection. Find out more…

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Mitral valve replacement and repair

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Cardiogenic shock: transcatheter solutions

17 Nov 2025 – From PCR London Valves 2025

This session focuses on transcatheter solutions for cardiogenic shock, highlighting rescue therapies such as mitral clip intervention in hypertrophic obstructive cardiomyopathy, valve-in-valve TAVI during CPR, and sequential mechanical circulatory support. It presents complex clinical cases illustrating stepwise approaches combining mechanical support and percutaneous valve repair to...

New transcatheter mitral valve devices

17 Nov 2025 – From PCR London Valves 2025

This session reviews emerging transcatheter mitral valve devices and their clinical applications. Topics include managing recurrent mitral regurgitation with combined ELASTA-Clip and TMVR approaches, TMVR use in elderly patients, surgical perspectives on device selection, multimodal percutaneous strategies for functional mitral regurgitation, and TMVR as a novel...

Featured research - Mitral valve interventions: Physiology & device innovation

17 Nov 2025 – From PCR London Valves 2025

This session highlights groundbreaking research on mitral valve interventions featuring advanced transcatheter techniques. Topics include coronary physiology assessment with vFFR in severe mitral regurgitation, predictive versus actual outcomes in TMVR, innovative devices like Epygon and INNOVALVE, and novel approaches such as the ReNiva posterior leaflet replacement...

Featured research - Mitral valve interventions: Physiology & device innovation

Interventions in shock

17 Nov 2025 – From PCR London Valves 2025

This session addresses critical interventions in cardiogenic shock, highlighting innovative approaches such as combined valve procedures, management of acute functional mitral regurgitation in STEMI, and advanced transcatheter edge-to-edge repair techniques in refractory heart failure. It offers a comprehensive exploration of strategies to navigate complex hemodynamic instability...

Best clinical cases & Early Career Research Award

17 Nov 2025 – From PCR London Valves 2025

Explore a series of innovative clinical cases highlighting the integration of advanced expertise and AI in managing complex structural heart interventions. This session includes compelling cases such as the use of ANCHOR BASILICA to prevent coronary obstruction, the Lithotripsy-BATMAN technique for mitral valve interventions in calcified...

Best clinical cases & Early Career Research Award

What are the key considerations for transcatheter mitral paravalvular leak management?

18 Nov 2025 – From PCR London Valves 2025

Nina Wunderlich and Patrick Calvert discuss mitral paravalvular leaks, which are relatively common. Percutaneous closure is now the default approach, and imaging is central to success: detailed pre-procedural assessment, 3D TOE during the procedure, and careful planning of transseptal puncture. 

This interview was filmed at PCR London...

What are the key considerations for transcatheter mitral paravalvular leak management?

TAVI for aortic regurgitation in high surgical risk: outcomes in 700 patients from ALIGN-AR

16 Nov 2025 – From PCR London Valves 2025

Christopher Allen and Raj Makkar sit down to review the ALIGN-AR trial and its implications for treating native aortic regurgitation. 

ALIGN-AR was a pivotal, single-arm, multicenter investigational study designed to evaluate a dedicated transcatheter solution in patients with moderate-to-severe native AR who were considered high risk for...

Outcomes in 700 patients from ALIGN-AR regarding TAVI for AR in high surgical risk

Is iatrogenic atrial septum defect closure a necessary procedure?

17 Nov 2025 – From PCR London Valves 2025

Philipp Lurz and Saibal Kar discuss iatrogenic atrial septal defects from transseptal procedures. Small ones usually close on their own, while large defects causing significant shunting need closure to prevent right heart overload. Some moderate defects may be beneficial by decompressing the left atrium, so closure...

Is iatrogenic atrial septum defect closure a necessary procedure?

What are the key considerations when managing combined mitral and tricuspid regurgitation?

17 Nov 2025 – From PCR London Valves 2025

Fabien Praz and Neil Fam talk about the management of patients with combined mitral and tricuspid regurgitation, who are often elderly with heart failure and multiple comorbidities. Careful assessment—including echocardiography, hemodynamics, and sometimes CT—is crucial to identify the dominant lesion. Surgery is preferred if feasible, but...

What are the key considerations when managing combined mitral and tricuspid regurgitation?

How do we meet the needs of women with heart valve disease?

17 Nov 2025 – From PCR London Valves 2025

In this interview, Ellen Ross and Marta Sitges discuss a recent initiative from Global Heart Hub - a patient association - which examined the realities faced by women living with heart valve disease. They outline the gaps identified, the call to action that followed, and how...

How do we meet the needs of women with heart valve disease?