25 Feb 2019
2-year outcome of the 3-arm BIO-RESORT randomised trial in all-comer patients treated with contemporary DES
EuroIntervention Journal
Modern biodegradable coating DES, such as the sirolimus-eluting Orsiro and everolimus-eluting Synergy stents, combine flexible thin-strut designs with thin bioresorbable drug-eluting coatings. The polymer coating of the Synergy stent is resorbed within 4 months, while the coating of the Orsiro stent degrades after >12 months, which is why the present follow-up of this randomised clinical trial beyond de primary clinical endpoint at 12 months is of great interest.
The present, large scale BIO-RESORT randomised trial has demonstrated non-inferiority of the biodegradable polymer Orsiro and Synergy stents versus the durable polymer Resolute Integrity stent at 1-year follow-up. At 1-year follow-up 85.6% of the patients were on DAPT. The aim of this study is to evaluate in all-comer PCI patients the 2-year safety and efficacy of treatment with contemporary very thin-strut biodegradable polymer Synergy and Orsiro versus thin-strut Resolute Integrity DES.
Authors
Marlies M. Kok, Paolo Zocca, Rosaly A. Buiten, Peter W. Dansen, Carl E. Schotborgh, Martijn Scholte, Marc Hartmann, Martin G. Stoel, K. Gert van Houwelingen, Gerard C.M. Linssen, Carine J. M. Doggen, Clemens von Birgelen
