38 results
Percutaneous coronary intervention versus coronary artery bypass grafting in patients with left main disease with and without diabetes: findings from a pooled analysis of 4 randomized clinical trials
30 Apr 2024
This analysis shows that diabetic patients undergoing revascularization face substantially higher 5-year rates of all-cause mortality, myocardial infarction, repeat revascularizations, and stroke compared to non-diabetic patients.

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Bifurcation left main stenting with or without intracoronary imaging: Outcomes from the EBC MAIN trial
08 Aug 2023
This sub-analysis of EBC MAIN aimed to determine if intracoronary imaging use during LM bifurcation PCI was associated with fewer MACE, for patients treated with a planned dual‐stenting strategy versus provisional strategy.

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Percutaneous coronary intervention vs coronary artery bypass graft surgery for left main disease in patients with and without acute coronary syndromes: a pooled analysis of 4 randomized clinical trials
05 Jul 2023
This patient-level analysis of randomized trials comparing PCI vs CABG for the treatment of low-to-intermediate CAD involving the LM confirms the absence of long-term differences in mortality between revascularization techniques, regardless of the clinical presentation.

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PCI or CABG for left main coronary artery disease: the SWEDEHEART registry
28 Jun 2023
While the choice between PCI and CABG for LMCA disease continues to be one of the most controversial topics, patient characteristics & comorbidities must be taken into account, as must the external validity of the results of RCTs in the real world, as the SWEDEHEART registry does.

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Reviewer
Stepwise provisional versus systematic culotte for stenting of true coronary bifurcation lesions: five-year follow-up of the multicentre randomised EBC TWO Trial
16 Jun 2023
The investigator initiated, multicentre, randomised, EBC TWO trial compared a provisional strategy with a systematic culotte technique in patients with true non-LMS bifurcation disease. At one year, there was no difference between the groups in terms of the composite endpoint of all-cause mortality, MI or TVR....

Reviewer
The 17th expert consensus document of the European Bifurcation Club – techniques to preserve access to the side branch during stepwise provisional stenting
15 Jun 2023
Provisional stenting (PS) is the default approach for treating most coronary bifurcation lesions (CBL). The side branch (SB) can be compromised after main vessel (MV) stenting in up to 6-18 % of cases. The 17th Expert consensus document of the European Bifurcation Club details strategies for...

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Outcomes of medical therapy plus PCI for multivessel or left main CAD ineligible for surgery
09 Mar 2023
The OPTIMUM study evaluates the outcomes in patients with complex CAD, including significant LM disease, its equivalent, or MVD CAD, undergoing percutaneous revascularization in addition to guideline directed medical therapy (GDMT) versus GDMT alone.

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Left main stem percutaneous coronary intervention: does on-site surgical cover make a difference?
28 Oct 2022
The current analysis examines patient characteristics and outcomes following LM PCI performed in NSC in England and Wales.

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A large, prospective, multicentre study of left main PCI using a latest-generation zotarolimus-eluting stent: the ROLEX study
24 Oct 2022
The purpose of the ROLEX Registry (Revascularization Of LEft main with resolute onyX) was to explore outcomes using a more contemporary drug eluting stent platform which is more suitable for LM PCI.

Reviewer
Durable polymer vs. biodegradable polymer DES in patients with ACS undergoing complex PCI: A post hoc analysis of the HOST-REDUCE-POLYTECH-ACS trial
30 Aug 2022
The HOST-REDUCE-POLYTECH-ACS trial was a randomised, parallel-group multicentre trial with a 2x2 factorial design testing two independent hypotheses, one of which was the non-inferiority of durable polymer drug-eluting stents (DP-DES) to biodegradable polymer drug-eluting stents (BP-DES) in patients with ACS. In this post-hoc analysis, the authors...

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