NSTEMI (Non-ST-segment elevation myocardial infarction)

Find all the latest content on NSTEMI published on this website.

NSTEMI is considered one of the leading causes of morbidity and mortality and its definition and treatment remains challenging requiring specific, adapted responses. Understanding different biomarkers, becoming aware of emerging new agents used in adjunctive pharmacotherapy, keeping abreast of advances in imaging techniques as well as the use of invasive imaging and functional assessment is critical. Tools, devices and techniques, and complications such as different types of vascular access or bleeding risks, can also be found here…

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NSTEMI

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REALITY - A trial of transfusion strategies for myocardial infarction and anemia

03 Sep 2020

ESC Congress 2020: Tabassome Simon (Paris, France) discusses with Francesco Costa the results of REALITY trial which supports the use of a restrictive strategy for blood transfusion in MI patients with anemia.

Francesco Costa

Author

Francesco Costa
REALITY - A trial of transfusion strategies for myocardial infarction and anemia

Improving outcomes after PCI: what can interventionalists learn from the ATPCI trial?

02 Sep 2020

Professor Roberto Ferrari presented the results of the ATPCI trial on Sunday, August 30th, in a Hot Line session of the ESC Congress 2020 The Digital Experience. Dejan Milasinovic provides his analysis of this study.

Dejan Milasinovic

Author

Dejan Milasinovic
Improving outcomes after PCI: what can interventionalists learn from the ATPCI trial?

What’s new in the 2020 ESC Clinical Practice Guideline on the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (NSTE-ACS)?

29 Aug 2020

Majority of ischemic heart disease patients present with NSTEACS . Management of NSTEACS starts with correct diagnosis, appropriate timely initiation of the right pharmacotherapy, provision of coronary angiography/intervention procedures and secondary preventative care. 5 years on from the last ESC NSTEACS guidelines, what does the new...

Vijay Kunadian

Author

Vijay Kunadian
ESC NSTEACS guidelines 2020

Revascularisation strategies - PCR e-Course 2020 Hot lines

29 Jul 2020 – From PCR e-Course 2020

Watch a series of Hot Lines on revascularisation presented during the PCR e-Course 2020, followed by an analysis of the results and their impact on your practice: ISIS II, REDUCER-I, RINCAL, SYNTAX score II 2020.

Revascularisation strategies

PCR Trials: Ticagrelor versus Clopidogrel in ACS and invasive management (TICAKOREA)

24 Jul 2020

The objective of this study is to compare the safety and efficacy of ticagrelor with clopidogrel in patients with ACS.

Authors :

Park et al. Circulation. 2019;140:1865-77
PCR Trials: Ticagrelor versus Clopidogrel in ACS and invasive management (TICAKOREA)

Randomised comparison of the polymer-free biolimus-coated BioFreedom stent with the ultrathin strut biodegradable polymer sirolimus-eluting Orsiro stent in an all-comers population treated with PCI: the SORT OUT IX Trial

03 Jul 2020

While investigations testing differences in efficacy and safety between drug-eluting stents according to the characteristics of the coating – durable, bioresorbable, or polymer-free – have shown mixed results, several studies have highlighted the benefit of implanting a device with thinner strut.

Daniele Giacoppo

Reviewer

Daniele Giacoppo
The SORT OUT IX trial

Effect of ticagrelor monotherapy vs ticagrelor with aspirin on major bleeding and cardiovascular events in patients with acute coronary syndrome : the TICO randomised clinical trial

02 Jul 2020

The outstanding results of the TICO trial have to be interpreted in light of a number of considerations and the generalisability of its results in other contexts requires further analysis.

Daniele Giacoppo

Reviewer

Daniele Giacoppo
Effect of ticagrelor monotherapy vs ticagrelor with aspirin on major bleeding and cardiovascular events in patients with ACS : the TICO randomized clinical trial

Physiology or intracoronary imaging; or both? or none? - part 1

27 Jun 2020 – From PCR e-Course 2020

Watch a series of studies on physiology and intracoronary imaging presented during the PCR e-Course 2020, followed by an analysis of the results and their impact on your practice: SCAAR report, a sub-analysis of the FORZA trial, diagnostic accuracy of IVUS-based FFR.

Physiology or intracoronary imaging; or both? or none?

Hot line on PCI: high bleeding risk and DAPT - part 1

26 Jun 2020 – From PCR e-Course 2020

Watch a series of Hot Lines on high bleeding risk and DAPT presented during the PCR e-Course 2020, followed by an analysis of the results and their impact on your practice: ARC-HBR, MODEL U-SES, Onyx ONE trials.

Hot line on PCI: high bleeding risk and DAPT

Aspirin vs. P2Y12 monotherapy in Onyx-1

26 Jun 2020 – From PCR e-Course 2020

Watch this session if you want to review the highlights of the Onyx ONE Month DAPT Program and to listen to commentary on the SAPT late breaker sub-analysis comparing the safety and efficacy of administering aspirin vs. P2Y12 inhibitor.

Videos included on this page: the Hot Line...

Aspirin vs. P2Y12 monotherapy in Onyx-1

Prevention and management of coronary complications

25 Jun 2020 – From PCR e-Course 2020

Watch this session to discover clinical cases with different PCI-related complications, and learn how to minimise their risks and how to best manage them.

This session was originally presented during PCR e-Course 2020.

Prevention and management of coronary complications

PCR e-Course 2020 Clinical cases

25 Jun 2020 – From PCR e-Course 2020

Watch a series of best clinical cases presented at the PCR e-Course 2020:

  • ACS-patient with culprit in a coronary ectasia
  • Coronary stenting in an ectatic artery
  • Challenging PCI after aortic valve-in-valve implantation
  • Cisplatin-induced coronary artery thrombosis presented as ACS
  • MOCA I study: microvascular obstruction measured using dMVR
  • The many faces of in-stent...
PCR e-Course Clinical cases

Last frontiers in treatment of high bleeding risk patients

Watch this session if you want to learn from experts the complexity of HBR patients, to discover newest data on DAPT in this population and to get a first-hand update on upcoming major development in DAPT for HBR patients.

Speaker: Davide Capodanno

This interview supported by Terumo was...

Last frontiers in treatment of high bleeding risk patients

A COVID(+) patient with STEMI and prior PCI

27 May 2020

Flavio Ribichini and Thomas Cuisset discuss a case of a COVID(+) patient with STEMI and prior PCI presented by Alejandro Ricalde.

PCR on Call - A COVID(+) patient with STEMI and prior PCI

Ticagrelor or prasugrel in patients with acute coronary syndromes - ISAR-REACT 5

06 Apr 2020

The objective of the Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment (ISAR-REACT) 5 trial is to test the hypothesis that the ticagrelor strategy is superior to prasugrel strategy in patients with ACS in a composite clinical outcomes.

Mehdi Hadid

Reviewer

Mehdi Hadid

Reviewer

Romain Didier
Ticagrelor or prasugrel in patients with ACS

COVID-19: Providing ongoing care to patients with cardiovascular disease in a pandemic

20 Mar 2020

The world is facing unprecedented challenges as a result of a bug called COVID-19 (Sars-CoV-2) that has literally gone “viral” across the globe affecting >250K individuals in 183/195 countries, claiming >10,000 lives in a short period of time (as of 15:00 20/3/2020). 

Vijay Kunadian

Author

Vijay Kunadian
COVID19

Morphine and cardiovascular outcomes among patients with non-ST-segment elevation acute coronary syndromes undergoing coronary angiography

17 Feb 2020

EARLY ACS was a randomised control trial assessing early versus delayed use of eptifibatide in patients presenting with NSTE-ACS and high-risk features. In this subanalysis, the authors evaluate the association between morphine and ischaemic events in patients pre-treated with clopidogrel.

Nicola Ryan

Reviewer

Nicola Ryan
Dejan Milasinovic

Reviewer

Dejan Milasinovic
Morphine and cardiovascular outcomes among patients with non-ST-Segment elevation ACS undergoing coronary angiography

Interactive Case Corner 5 - Coronary CTO & ACS NSTEMI

18 Dec 2019 – From GulfPCR-GIM 2019

Consult this session to discover two clinical cases on coronary CTO and ACS NSTEMI, and learn how to reduce radiation exposure to the patient during the procedure.

Interactive Case Corner 5 - Coronary CTO & ACS NSTEMI

Interactive Case Corner 1 - Thrombosed AVG, bifurcation lesions & diffuse CAD

18 Dec 2019 – From GulfPCR-GIM 2019

Consult this session to discover a selection of challenging clinical cases, such as myocardial revascularisation in diffuse CAD, PCI of bifurcation lesion with DK crush technique, angioplasty of totally thrombosed arteriovenous graft, and more!

Interactive Case Corner 1 - Thrombosed AVG, bifurcation lesions & diffuse CAD

Ticagrelor alone versus dual antiplatelet therapy from 1 month after drug-eluting coronary stenting

10 Nov 2019

One of the most discussed limitations of GLOBAL-LEADER is the lack of event adjudication so that the rate of MI, bleeding or stent thrombosis between the two groups were unknown. In this study, events were adjudicated in those patients from the 20 top-enrolling participating sites.

Reviewer

Salvatore Brugaletta
Ticagrelor alone versus dual antiplatelet therapy from 1 month after drug-eluting coronary stenting