NSTEMI (Non-ST-segment elevation myocardial infarction)

Find all the latest content on NSTEMI published on this website.

NSTEMI is considered one of the leading causes of morbidity and mortality and its definition and treatment remains challenging requiring specific, adapted responses. Understanding different biomarkers, becoming aware of emerging new agents used in adjunctive pharmacotherapy, keeping abreast of advances in imaging techniques as well as the use of invasive imaging and functional assessment is critical. Tools, devices and techniques, and complications such as different types of vascular access or bleeding risks, can also be found here…

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NSTEMI

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NSTEMI PCI: LIVE case from St Thomas' Hospital - London, United Kingdom

17 May 2022 – From EuroPCR 2022

Watch the case of a 65-year-old ex-smoker, male patient, with hypertension and cholesterol, who presented with chest pain at rest, symptomatic with nausea and dizziness, and find out how this NSTE-ACE patient was treated.

NSTEMI PCI: LIVE case from St Thomas' Hospital - London, United Kingdom

When the barrier is crossed: dealing with iatrogenic dissection and perforation

17 May 2022 – From EuroPCR 2022

Consult this session to learn more about what to do when facing iatrogenic dissection and perforation, and discover some novel approaches and techniques to seal them, thanks to a selection of cases: sub-intimal stent placement after dissection, wire fracture followed by coronary dissection, and much more!

When the barrier is crossed: dealing with iatrogenic dissection and perforation

Repeat NSTEMI late after self-expanding TAVR

17 May 2022 – From EuroPCR 2022

Discover the case of a 79 year-old man presenting to the ER with NSTEMI and chest pain, with an history of NSTEMI with PCI and TAVR (CTO of the dominated RCA and intermediate stenosis of the proximal LAD). Angiography reveals a tight stenosis of proximal and...

Repeat NSTEMI late after self-expanding TAVR

PACMAN AMI: Effects of Alirocumab on Coronary Atherosclerosis Assessed by Serial Multimodality Intracoronary Imaging in Patients With Acute Myocardial Infarction

03 Apr 2022

Nicola Ryan provides a PICOT analysis of PACMAN AMI: a double-blind, placebo-controlled, randomized trial presented at ACC 2022 and simultaneously published in JAMA.

Nicola Ryan

Author

Nicola Ryan
PACMAN AMI: Effects of Alirocumab on Coronary Atherosclerosis Assessed by Serial Multimodality Intracoronary Imaging in Patients With Acute Myocardial Infarction: A Double-blind, Placebo-controlled, Randomized Trial

OCT conundrum during PCI

18 Mar 2022

How did one coronary lesion become three lesions by OCT?

Richard H. Sohn

Author

Richard H. Sohn
OCT conundrum during PCI

Risk of cardiovascular hospital admission after exposure to fine particulate pollution

23 Feb 2022

This current study explored the effect of heavy particle pollution on total cardiovascular admissions, whilst also looking at risk for specific cardiovascular diagnoses, such as angina, myocardial infarction, and ischaemic stroke.

Reviewer

Bawan Abdulaziz
Kalpa De Silva

Reviewer

Kalpa De Silva
Risk of cardiovascular hospital admission after exposure to fine particulate pollution

Improved 3-year cardiac survival after IVUS-guided long DES implantation: a patient-level analysis from 2 randomized trials

02 Feb 2022

This study aimed to increase the power to detect differences in patient survival (freedom from cardiac deaths) with IVUS versus angiography guidance by pooling the individual patient data from the IVUS-XPL and ULTIMATE trials.

Nicola Ryan

Reviewer

Nicola Ryan
Improved 3-year cardiac survival after IVUS-guided long DES implantation: a patient-level analysis from 2 randomized trials

Ticagrelor monotherapy after PCI in high-risk patients with prior MI: a prespecified TWILIGHT substudy

31 Jan 2022

In this prespecified subgroup analysis of the TWILIGHT trial, the authors report the impact of prior MI on treatment effects of ticagrelor monotherapy compared to ticagrelor and aspirin in patients at least three months post PCI...

Nicola Ryan

Reviewer

Nicola Ryan
Ticagrelor monotherapy after PCI in high-risk patients with prior MI: a prespecified TWILIGHT substudy

Best of #AHA21 Scientific Sessions: coronary and valvular heart disease trials

14 Nov 2021

Vijay Kunadian provides summaries of study designs and findings in Interventional Cardiology released at the 2021 virtual edition of the American Heart Association Congress. View an infographic of the AVATAR late-breaking trial by Ali Nazmi Calik.

Vijay Kunadian

Author

Vijay Kunadian
Best of #AHA21 Scientific sessions

Fractional flow reserve to guide treatment of patients with multivessel coronary artery disease - the FUTURE trial

05 Nov 2021

The FUTURE Trial is a prospective randomised, multicentre, open label superiority trial comparing an FFR guided treatment strategy to traditional angiography guided treatment strategy on clinical outcomes in an all-comer population with multivessel coronary artery disease.

Nicola Ryan

Reviewer

Nicola Ryan
Fractional flow reserve to guide treatment of patients with multivessel coronary artery disease - the FUTURE trial

iFR-SWEDEHEART: iFR vs FFR-Guided Coronary Revascularisation

04 Nov 2021

Nicola Ryan reviews the iFR Swedeheart multicenter, randomized, controlled, open-label clinical trial using the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) for enrolment randomisation and follow up. At one year follow up iFR guided revascularisation was shown to be non-inferior to FFR guided revascularisation, these results...

Nicola Ryan

Author

Nicola Ryan
iFR-SWEDEHEART: Five-Year Outcomes of a Randomized Trial of iFR-Guided vs. FFR-Guided PCI

Impact of intravascular ultrasound on long-term clinical outcomes in patients with acute myocardial infarction

04 Nov 2021

There are limited data evaluating long-term outcomes of IVUS use in patients with acute myocardial infarction (AMI). The aim of this study was to examine the impact of IVUS-guided PCI on long-term clinical outcomes in patients with AMI.

Francesco Spione

Reviewer

Francesco Spione

Reviewer

Salvatore Brugaletta
Impact of intravascular ultrasound on long-term clinical outcomes in patients with acute myocardial infarction

Ticagrelor monotherapy in patients at high bleeding risk undergoing percutaneous coronary intervention: TWILIGHT-HBR

28 Oct 2021

To further investigate the treatment effects of ticagrelor monotherapy compared with ticagrelor plus aspirin in a contemporary HBR population, a pre-specified analysis of the TWILIGHT trial, TWILIGHT-HBR, was conducted by using the Academic Research Consortium (ARC) criteria for HBR.

Reviewer

Ali Nazmi Calik
Elif Ilkay Yuce

Reviewer

Elif Ilkay Yuce
Ticagrelor monotherapy in patients at high bleeding risk undergoing percutaneous coronary intervention: TWILIGHT-HBR

Abstracts on pharmacotherapy and vascular access

08 Oct 2021 – From AICT AsiaPCR 2021

Watch this session to discover three abstracts on pharmacotherapy and vascular access: a molecular analysis of CYP2C19 alleles and clopidogrel resistance among Bangladeshi patients with ACS, a transradial vs. transfemoral approach in coronary angioplasty using rotational atherectomy, as well as a potential new interventional therapy with Phosphatidylcholine/deoxycholate to...

Abstracts on pharmacotherapy and vascular access

Cases on complications of coronary perforation: STEMI & NSTEMI

08 Oct 2021 – From AICT AsiaPCR 2021

Watch this session to learn more about complications of coronary perforation, thanks to a selection of two challenging cases: a percutaneous ventricular support device absorbing guidewire during STEMI PCI, as well as a guidewire-induced perforation of tortuous small distal coronary artery.

Cases on complications of coronary perforation: STEMI & NSTEMI

Treating complex coronary lesions: right case right time Prevail™ DCB

01 Oct 2021 – From AICT-AsiaPCR 2021

Thanks to this session, find out more about indications for drug-coated balloons, or, on the contrary, learn when not to use it. And through the analysis of two concrete cases, see how DCB can be an important tool to tackle increasingly complex patients and anatomies, especially...

Treating complex coronary lesions: right case right time Prevail™ DCB

Telescope guide extension catheter in complex coronary interventions

01 Oct 2021 – From AICT-AsiaPCR 2021

View the complex case of this 70-year-old male patient with hypertension and diabetes who presented with chest pain and NSTEMI, which shows that, when dealing with challenging calcific disease, guide catheter extensions help improve device delivery.

Telescope guide extension

Influenza Vaccination after Myocardial Infarction: IAMI

24 Sep 2021

The objective of the IAMI1 trial was to determine whether early influenza vaccination reduces the risk of cardiovascular events in patients admitted with an acute-MI or high-risk stable coronary artery disease in an adequately powered randomized control trial setting.

Christopher Johnston

Reviewer

Christopher Johnston
Kalpa De Silva

Reviewer

Kalpa De Silva
Influenza Vaccination after Myocardial Infarction: IAMI

Treatment effects of Interleukin-6 receptor antibodies for modulating the systemic inflammatory response after out-of-hospital cardiac arrest: the IMICA Trial

21 Sep 2021

The IMICA trial explored the effect of a single 1-hour infusion of Tocilizumab, initiated in patients as early as feasible in their hospital admission, post-cardiac arrest, and sought to investigate whether this would reduce the systemic inflammatory response.

Paul Hill

Reviewer

Paul Hill
Kalpa De Silva

Reviewer

Kalpa De Silva
Treatment effects of Interleukin-6 receptor antibodies for modulating the systemic inflammatory response after out-of-hospital cardiac arrest: the IMICA Trial

STOPDAPT-2 ACS: exploring the limits of short DAPT

31 Aug 2021

Hirotoshi Watanabe (Kyoto, Japan) presented the results of the STOPDAPT-2 ACS trial in a Hot Line session of the ESC Congress 2021. Dejan Milasinovic provides his analysis of this study.

Dejan Milasinovic

Author

Dejan Milasinovic
ESC Congress 2021 - STOPDAPT-2 ACS: exploring the limits of short DAPT